| Name | homeobox |
|---|---|
| Synonyms | HPX 6; HPX6; LBX 1; LBX1; LBX1H; Lady bird like homeobox; Ladybird homeobox protein homolog 1; Transcription factor LBX1… |
| Name | EXD |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 7635057 | Gonzalez-Crespo S, Morata G: Control of Drosophila adult pattern by extradenticle. Development. 1995 Jul;121(7):2117-25. The homeobox gene extradenticle (exd) acts as a cofactor of the homeotic genes in the specification of larval patterns during embryogenesis. |
31(0,1,1,1) | Details |
| 9436985 | Azpiazu N, Morata G: Functional and regulatory interactions between Hox and extradenticle genes. Genes Dev. 1998 Jan 15;12(2):261-73. The homeobox gene extradenticle (exd) acts as a cofactor of Hox function both in Drosophila and vertebrates. |
31(0,1,1,1) | Details |
| 9012512 | Gonzalez-Crespo S, Morata G: Genetic evidence for the subdivision of the arthropod limb into coxopodite and telopodite. Development. 1996 Dec;122(12):3921-8. Here, we present evidence that another homeobox gene, extradenticle (exd), which is required for appropriate development of the trunk and the proximal parts of the appendages, represents a coxopodite gene. |
7(0,0,1,2) | Details |
| 9450936 | Pai CY, Kuo TS, Jaw TJ, Kurant E, Chen CT, Bessarab DA, Salzberg A, Sun YH: The Homothorax homeoprotein activates the nuclear localization of another homeoprotein, extradenticle, and suppresses eye development in Drosophila. Genes Dev. 1998 Feb 1;12(3):435-46. We report the cloning of the Drosophila homothorax (hth) gene, a homolog of the mouse Meis1 proto-oncogene that has a homeobox related to that of exd. |
6(0,0,1,1) | Details |
| 7565694 | Moskow JJ, Bullrich F, Huebner K, Daar IO, Buchberg AM: Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice. Mol Cell Biol. 1995 Oct;15(10):5434-43. The homeodomain of Meis1 is most closely related to those of the PBX/exd family of homeobox protein-encoding genes, suggesting that Meis1 functions in a similar fashion by cooperative binding to a distinct subset of HOX proteins. |
3(0,0,0,3) | Details |
| 11566847 | Inbal A, Halachmi N, Dibner C, Frank D, Salzberg A: Genetic evidence for the transcriptional-activating function of Homothorax during adult fly development. Development. 2001 Sep;128(18):3405-13. Homothorax (HTH) is a homeobox-containing protein, which plays multiple roles in the development of the embryo and the adult fly. |
1(0,0,0,1) | Details |
| 18422304 | Moretti R, Donato LJ, Brezinski ML, Stafford RL, Hoff H, Thorson JS, Dervan PB, Ansari AZ: Targeted chemical wedges reveal the role of allosteric DNA modulation in protein-DNA assembly. ACS Chem Biol. 2008 Apr 18;3(4):220-9. Such cooperative binding plays a critical role in imparting exquisite sequence specificity on the homeobox transcription factor (Hox) family of developmental transcription factors. A well-characterized example includes the interaction of Hox proteins with extradenticle (Exd), a highly conserved DNA binding transcription factor. |
1(0,0,0,1) | Details |
| 12385754 | Azpiazu N, Morata G: Distinct functions of homothorax in leg development in Drosophila. Mech Dev. 2002 Nov;119(1):55-67. The proximal domain is defined by the activity of the homeobox genes homothorax and extradenticle and the distal one by the Dpp/Wg targets Distal-less (Dll) and dachshund (dac). It is known that hth/exd function prevents the activity of Dpp and Wg response genes and that cells deficient for exd activity in the proximal domain differentiate pattern elements corresponding to more distal leg regions. |
1(0,0,0,1) | Details |
| 10586884 | Mercader N, Leonardo E, Azpiazu N, Serrano A, Morata G, Martinez C, Torres M: Conserved regulation of proximodistal limb axis development by Meis1/Hth. Nature. 1999 Nov 25;402(6760):425-9. Here we describe the role of the homeobox genes Meis1/2 and Pbx1 in the development of mouse, chicken and Drosophila limbs. We find that Meis1/2 expression is restricted to a proximal domain, coincident with the previously reported domain in which Pbx1 is localized to the nucleus, and resembling the distribution of the Drosophila homologues homothorax (hth) and extradenticle (exd); that Meis1 regulates Pbx1 activity by promoting nuclear import of the Pbx1 protein; and that ectopic expression of Meis1 in chicken and hth in Drosophila disrupts distal limb development and induces distal-to-proximal transformations. |
1(0,0,0,1) | Details |
| 9729490 | Abu-Shaar M, Mann RS: Generation of multiple antagonistic domains along the proximodistal axis during Drosophila leg development. Development. 1998 Oct;125(19):3821-30. homothorax (hth) is a Drosophila member of the Meis family of homeobox genes. hth function is required for the nuclear localization of the Hox cofactor Extradenticle (EXD). We show here that there is also a post-transcriptional control of HTH by exd: exd activity is required for the apparent stability of the HTH protein. |
1(0,0,0,1) | Details |
| 8104703 | Rauskolb C, Peifer M, Wieschaus E: extradenticle, a regulator of homeotic gene activity, is a homolog of the homeobox-containing human proto-oncogene pbx1. Cell. 1993 Sep 24;74(6):1101-12. Mutations in the Drosophila gene extradenticle (exd) cause homeotic transformations by altering the morphological consequences of homeotic selector gene activity. |
1(0,0,0,1) | Details |
| 9671305 | Gonzalez-Crespo S, Abu-Shaar M, Torres M, Martinez-A C, Mann RS, Morata G: Antagonism between extradenticle function and Hedgehog signalling in the developing limb. Nature. 1998 Jul 9;394(6689):196-200. The Drosophila homeobox gene extradenticle (exd) encodes a highly conserved cofactor of Hox proteins. exd activity is regulated post-translationally by a mechanism involving nuclear translocation; only nuclear Exd protein is functional. |
81(1,1,1,1) | Details |