| Name | phosphodiesterase |
|---|---|
| Synonyms | CAMP specific phosphodiesterase variant PDE4A 10; CAMP specific phosphodiesterase variant TM3; CAMP specific phosphodiesterase; Cyclic AMP phosphodiesterase PDE4A11; Cyclic AMP specific phosphodiesterase HSPDE4A10; DPDE 2; DPDE2; PDE 4… |
| Name | atrazine |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16426721 | Roberge MT, Hakk H, Larsen G: Cytosolic and localized inhibition of phosphodiesterase by atrazine in swine tissue homogenates. Food Chem Toxicol. 2006 Jun;44(6):885-90. Epub 2006 Jan 19. |
81(1,1,1,1) | Details |
| 12127262 | Sanderson JT, Boerma J, Lansbergen GW, van den Berg M: Induction and inhibition of aromatase (CYP19) activity by various classes of pesticides in H295R human adrenocortical carcinoma cells. Toxicol Appl Pharmacol. 2002 Jul 1;182(1):44-54. Time-response curves for cAMP induction and concentration-response curves for aromatase induction by vinclozolin, atrazine, and IBMX were similar, suggesting that the mechanism of aromatase induction by these pesticides is mediated through inhibition of phosphodiesterase activity. |
81(1,1,1,1) | Details |
| 19541795 | Pogrmic K, Fa S, Dakic V, Kaisarevic S, Kovacevic R: Atrazine oral exposure of peripubertal male rats downregulates steroidogenesis gene expression in Leydig cells. Toxicol Sci. 2009 Sep;111(1):189-97. Epub 2009 Jun 18. Leydig cells from treated rats were characterised by significant decline in mRNA transcripts of several genes responsible for steroidogenesis: luteinizing hormone receptor (LHR), scavenger receptor-B1, steroidogenic acute regulatory protein, translocator protein, steroidogenic factor-1, phosphodiesterase 4B, 3beta-hydroxysteroid dehydrogenase (HSD), CYP17A1, and 17betaHSD. |
1(0,0,0,1) | Details |
| 15475179 | Roberge M, Hakk H, Larsen G: Atrazine is a competitive inhibitor of phosphodiesterase but does not affect the estrogen receptor. Toxicol Lett. 2004 Dec 1;154(1-2):61-8. Therefore, ATR and its degradation products were studied to determine their ability to inhibit phosphodiesterase (PDE), the enzyme responsible for hydrolyzing the second messenger cAMP to 5'-AMP. |
1(0,0,0,1) | Details |
| 17520059 | Fan W, Yanase T, Morinaga H, Gondo S, Okabe T, Nomura M, Komatsu T, Morohashi K, Hayes TB, Takayanagi R, Nawata H: Atrazine-induced aromatase expression is SF-1 dependent: implications for endocrine disruption in wildlife and reproductive cancers in humans. Environ Health Perspect. 2007 May;115(5):720-7. Epub 2007 Feb 5. The mechanism involves the inhibition of phosphodiesterase and subsequent elevation of cAMP. |
1(0,0,0,1) | Details |