| Name | androgen receptor |
|---|---|
| Synonyms | AIS; AR; Androgen receptor; DHTR; Dihydrotestosterone receptor; HUMARA; KD; NR3C4… |
| Name | atrazine |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9171990 | Danzo BJ: Environmental xenobiotics may disrupt normal endocrine function by interfering with the binding of physiological ligands to steroid receptors and binding proteins. Environ Health Perspect. 1997 Mar;105(3):294-301. The gamma- and delta-isomers of hexachlorocyclohexane, congeners of dichlorodiphenyl-trichloroethane (DDT; p,p'-DDT; p,p'-DDE; o,p'-DDT), dieldrin, atrazine, and pentachlorophenol, caused a statistically significant inhibition of specific binding of [3H] 5 alpha-DHT to the androgen receptor that ranged from 100% (p,p'-DDE) to 25% (dieldrin). |
81(1,1,1,1) | Details |
| 7560742 | Kniewald J, Osredecki V, Gojmerac T, Zechner V, Kniewald Z: Effect of s-triazine compounds on metabolism in the rat prostate. J Appl Toxicol. 1995 May-Jun;15(3):215-8. The influence of s-triazine compounds (atrazine, prometryne and deethylatrazine) on conversion and 5 alpha-dihydrotestosterone-receptor complex formation was studied in vitro and in vivo in the rat prostate. |
81(1,1,1,1) | Details |
| 1705844 | Simic B, Kniewald Z, Davies JE, Kniewald J: Reversibility of the inhibitory effect of atrazine and lindane on cytosol 5 alpha-dihydrotestosterone receptor complex formation in rat prostate. Bull Environ Contam Toxicol. 1991 Jan;46(1):92-9. |
31(0,1,1,1) | Details |
| 20045047 | Victor-Costa AB, Bandeira SM, Oliveira AG, Mahecha GA, Oliveira CA: Changes in testicular morphology and steroidogenesis in adult rats exposed to Atrazine. Reprod Toxicol. 2010 Jan 4. We evaluated the effects of Atrazine (50mg/kg, 200mg/kg and 300mg/kg) in the 3beta-hydroxysteroid dehydrogenase (3beta-HSD) expression, plasmatic and testicular and levels, androgen receptor expression and morphological changes in adult rat testes. |
6(0,0,1,1) | Details |
| 15183528 | Tanaka T, Kohno H, Suzuki R, Sugie S: Lack of modifying effects of an estrogenic compound atrazine on 7,12-dimethylbenz (a) anthracene-induced ovarian carcinogenesis in rats. Cancer Lett. 2004 Jul 16;210(2):129-37. We also assessed the effect of atrazine on proliferating cell nuclear antigen (PCNA)-index and the expression of estrogen receptor (ER)-alpha and -beta and androgen receptor (AR) in induced neoplasms. |
6(0,0,1,1) | Details |
| 19186820 | Zhang ZB, Hu JY, Sai SX, Zhao YB, Huang C, Tian XJ: [Gene cloning, sequence analysis and tissue expression of estrogen-related receptor alpha (Erralpha) in Japanese medaka and its transcriptional responses after differential EDCs exposure]. Huan Jing Ke Xue. 2008 Nov;29(11):3153-8. After 3 weeks exposure of medaka to 200 ng/L (EE2), 200 ng/L (E1), 200 ng/L diethylstilbestrol (DES), 100 microg/L atrazine (AT) and 200 ng/L 17beta- (E2), transcripts of ERRalpha were significantly decreased to 0.54, 0.56, 0.61, 0.63 and 0.65 of control (p < 0.05) in the testes, respectively. The DBD of medaka ERRalpha is of the same length and has high sequence identity with those of estrogen receptor (ERalpha and ERbeta) and androgen receptor (ARalpha and ARbeta) of medaka, but much difference was found between the LBD of medaka ERRalpha with those of ERalpha, ERbeta, ARalpha and ARbeta. |
1(0,0,0,1) | Details |
| 7932848 | Tennant MK, Hill DS, Eldridge JC, Wetzel LT, Breckenridge CB, Stevens JT: Possible antiestrogenic properties of chloro-s-triazines in rat uterus. . J Toxicol Environ Health. 1994 Oct;43(2):183-96. Several published reports have indicated that certain chloro-s-triazine herbicides may alter endocrine function in rats, possibly by androgen receptor binding. In direct tests of estrogenic bioactivity, oral doses of up to 300 mg/kg/d of atrazine, simazine, or the common metabolite diaminochlorotriazine (DACT) did not significantly increase uterine weight of ovariectomized Sprague-Dawley female rats. |
1(0,0,0,1) | Details |
| 14751673 | Yamasaki K, Sawaki M, Noda S, Muroi T, Takakura S, Mitoma H, Sakamoto S, Nakai M, Yakabe Y: Comparison of the Hershberger assay and androgen receptor binding assay of twelve chemicals. Toxicology. 2004 Feb 15;195(2-3):177-86. The chemicals tested by the Hershberger assay were di-n-hexyl ester, di-n-amyl ester, di-n-propyl ester, diethylstilbestrol, 17beta- tamoxifen, dichlorodiphenyldichloroethane, cyproterone acetate, 6alpha-methyl-17alpha-- atrazine, and spironolactone. |
1(0,0,0,1) | Details |