Protein Information

Name tyrosine hydroxylase
Synonyms Putative tyrosine hydroxylase variant; TH; TH protein; TYH; Truncated tyrosine hydroxylase; Tyrosine 3 hydroxylase; Tyrosine 3 monooxygenase; Tyrosine hydroxylase…

Compound Information

Name cyanazine
CAS 2-[[4-chloro-6-(ethylamino)-1,3,5-triazin-2-yl]amino]-2-methylpropanenitrile

Reference List

PubMed Abstract RScore(About this table)
14550852 Das PC, McElroy WK, Cooper RL: Potential mechanisms responsible for chlorotriazine-induced alterations in catecholamines in pheochromocytoma (PC12) cells. Life Sci. 2003 Oct 31;73(24):3123-38.

In this study we evaluated the effect of atrazine, simazine and cyanazine on the protein expression of the enzymes responsible for the synthesis of dopamine [tyrosine hydroxylase (TH)] and norepinephrine [dopamine-beta-hydroxylase (DbetaH)].
81(1,1,1,1) Details
10910990 Das PC, McElroy WK, Cooper RL: Differential modulation of catecholamines by chlorotriazine herbicides in pheochromocytoma (PC12) cells in vitro. Toxicol Sci. 2000 Aug;56(2):324-31.

These data indicate that both atrazine and simazine inhibit the cellular synthesis of DA mediated by the tyrosine hydroxylase (TH), and NE mediated by dopamine beta-hydroxylase (DbetaH), and, as a result, there is a partial or significant inhibition of NE release.
Epidemiological, wildlife, and laboratory studies have pointed to the possible adverse health effects of chlorotriazine herbicide (i.e. , atrazine, simazine, and cyanazine) exposure.
1(0,0,0,1) Details