Protein Information

Name guanylate cyclase
Synonyms AMDM; Natriuretic peptide receptor; ANP B; ANPRB; Atrial natriuretic peptide B type receptor; Atrial natriuretic peptide receptor B; Atrial natriuretic peptide receptor B precursor (ANP B) (ANPRB) (GC B) (Guanylate cyclase B); Atrionatriuretic peptide receptor B…

Compound Information

Name amitrole
CAS

Reference List

PubMed Abstract RScore(About this table)
8719811 Mian KB, Martin W: The inhibitory effect of 3-amino-1,2,4-triazole on relaxation induced by hydroxylamine and sodium azide but not hydrogen peroxide or glyceryl trinitrate in rat aorta. Br J Pharmacol. 1995 Dec;116(8):3302-8.


Pretreatment of endothelium-denuded rings with methylene blue (MeB, 30 microM) inhibited relaxation induced by hydrogen peroxide (10 microM-1 mM), sodium azide (1-300 nM), hydroxylamine (1-300 nM) and glyceryl trinitrate (1-100 nM) suggesting that each acted by stimulation of soluble guanylate cyclase. 5.
2(0,0,0,2) Details
9612287 Weissmann N, Grimminger F, Voswinckel R, Conzen J, Seeger W: Nitro blue tetrazolium inhibits but does not mimic hypoxic vasoconstriction in isolated rabbit lungs. Am J Physiol. 1998 May;274(5 Pt 1):L721-7.


Both agents may stimulate guanylate cyclase, the latter via conversion to hydrogen peroxide and formation of compound I with catalase.
1(0,0,0,1) Details