Protein Information

Name aldehyde dehydrogenase (protein family or complex)
Synonyms aldehyde dehydrogenase; aldehyde dehydrogenases

Compound Information

Name amitrole
CAS

Reference List

PubMed Abstract RScore(About this table)
4040375 DeMaster EG, Shirota FN, Nagasawa HT: Catalase mediated conversion of cyanamide to an inhibitor of aldehyde dehydrogenase. Alcohol. 1985 Jan-Feb;2(1):117-21.

4(0,0,0,4) Details
11139414 Ward RJ, Kest W, Bruyeer P, Lallemand F, De Witte P: Taurine modulates catalase, aldehyde dehydrogenase, and ethanol elimination rates in rat brain. Alcohol Alcohol. 2001 Jan-Feb;36(1):39-43.

2(0,0,0,2) Details
6378202 DeMaster EG, Shirota FN, Nagasawa HT: The metabolic activation of cyanamide to an inhibitor of aldehyde dehydrogenase is catalyzed by catalase. Biochem Biophys Res Commun. 1984 Jul 18;122(1):358-65.

2(0,0,0,2) Details
9241662 He XX, Nebert DW, Vasiliou V, Zhu H, Shertzer HG: Genetic differences in alcohol drinking preference between inbred strains of mice. Pharmacogenetics. 1997 Jun;7(3):223-33.


In B6 mice, we found that oral treatment with the aldehyde dehydrogenase (ALDH) inhibitor disulfiram decreased alcohol preference by 50%, whereas oral treatment of the catalase inhibitor 3-amino-1,2,4-triazole increased alcohol drinking preference by 15-20%.
1(0,0,0,1) Details
17597213 Jamal M, Ameno K, Uekita I, Kumihashi M, Wang W, Ijiri I: Catalase mediates acetaldehyde formation in the striatum of free-moving rats. Neurotoxicology. 2007 Nov;28(6):1245-8. Epub 2007 May 13.


Rats received intraperitoneal EtOH (1g/kg) alone or in combination with 4-methylpyrazole (MP, 82 mg/kg, an alcohol dehydrogenase inhibitor), and/or catalase inhibitor sodium azide (AZ, 10mg/kg) or 3-amino-1,2,4-triazole (AT, 1g/kg), and/or cyanamide (CY, 50mg/kg, an aldehyde dehydrogenase inhibitor).
1(0,0,0,1) Details
7581830 Burdon RH, Alliangana D, Gill V: Hydrogen peroxide and the proliferation of BHK-21 cells. Free Radic Res. 1995 Nov;23(5):471-86.


In addition growth stimulatory concentrations of H2O2, whilst initially leading to increased intracellular levels of lipid peroxidation breakdown products, appear to "trigger" their metabolism, possibly through aldehyde dehydrogenase, whose activity is also stimulated by H2O2.
1(0,0,0,1) Details
3426683 Shirota FN, DeMaster EG, Kwon CH, Nagasawa HT: Metabolism of cyanamide to cyanide and an inhibitor of aldehyde dehydrogenase (ALDH) by rat liver microsomes. Alcohol Alcohol Suppl. 1987;1:219-23.

1(0,0,0,1) Details