| Name | cytochrome P450 (protein family or complex) |
|---|---|
| Synonyms | cytochrome P450; cytochrome P 450; CYP450; CYP 450 |
| Name | amitrole |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19603180 | Yu Q, Abdallah I, Han H, Owen M, Powles S: Distinct non-target site mechanisms endow resistance to ACCase and ALS-inhibiting herbicides in multiple herbicide-resistant Lolium rigidum. Planta. 2009 Sep;230(4):713-23. Epub 2009 Jul 15. By using the cytochrome P450 inhibitor malathion and amitrole with ALS and ACCase herbicides, respectively, we showed that malathion reverses chlorsulfuron resistance and amitrole reverses diclofop resistance in the R population examined. |
32(0,1,1,2) | Details |
| 3754327 | Francis VN, Dwarki VI, Padmanaban G: A comparative study of the regulation of cytochrome P-450 and glutathione transferase gene expression in rat liver. Nucleic Acids Res. 1986 Mar 25;14(6):2497-510. |
7(0,0,0,7) | Details |
| 3680282 | Dwarki VJ, Francis VN, Bhat GJ, Padmanaban G: Regulation of cytochrome P-450 messenger RNA and apoprotein levels by heme. J Biol Chem. 1987 Dec 15;262(35):16958-62. |
5(0,0,0,5) | Details |
| 3401013 | Bhat GJ, Padmanaban G: is a positive regulator of cytochrome P-450 gene transcription. Arch Biochem Biophys. 1988 Aug 1;264(2):584-90. |
4(0,0,0,4) | Details |
| 8250959 | Aniya Y, Shimoji M, Naito A: Increase in liver microsomal glutathione S-transferase activity by phenobarbital treatment of rats. Biochem Pharmacol. 1993 Nov 17;46(10):1741-7. Possible involvement of oxidative activation via cytochrome P450.. |
4(0,0,0,4) | Details |
| 10569634 | Shiba D, Shimamoto N: Attenuation of endogenous oxidative stress-induced cell death by cytochrome P450 inhibitors in primary cultures of rat hepatocytes. Free Radic Biol Med. 1999 Nov;27(9-10):1019-26. |
3(0,0,0,3) | Details |
| 3838174 | Ravishankar H, Padmanaban G: Regulation of cytochrome P-450 gene expression. J Biol Chem. 1985 Feb 10;260(3):1588-92. |
3(0,0,0,3) | Details |
| 6614916 | Ravishankar H, Padmanaban G: Effect of and 3-amino-1,2,4-triazole on the induction of cytochrome P-450 synthesis by phenobarbitone in rat liver. Arch Biochem Biophys. 1983 Aug;225(1):16-24. |
3(0,0,0,3) | Details |
| 10950858 | El-Kadi AO, Bleau AM, Dumont I, Maurice H, du Souich P: Role of reactive intermediates in the decrease of hepatic cytochrome P450 activity by serum of humans and rabbits with an acute inflammatory reaction. Drug Metab Dispos. 2000 Sep;28(9):1112-20. |
2(0,0,0,2) | Details |
| 9178193 | Matsubayashi K, Matsumoto H, Fukui Y: Contribution of cytochrome P450 3A pathway to bromocriptine metabolism and effects of ferrous iron and hypoxia-re-oxygenation on its elimination in the perfused rat liver. J Pharm Pharmacol. 1997 May;49(5):551-7. |
2(0,0,0,2) | Details |
| 4051505 | Tu YY, Yang CS: Demethylation and denitrosation of nitrosamines by cytochrome P-450 isozymes. Arch Biochem Biophys. 1985 Oct;242(1):32-40. |
2(0,0,0,2) | Details |
| 3954830 | Wickramasinghe SN: Observations on the biochemical basis of metabolism by human macrophages. Alcohol Alcohol. 1986;21(1):57-63. By contrast, 50-87% of the oxidation of by these cells was inhibited by and SKF-525A, all three of which are known to inhibit various species of microsomal cytochrome P-450. |
2(0,0,0,2) | Details |
| 3426683 | Shirota FN, DeMaster EG, Kwon CH, Nagasawa HT: Metabolism of cyanamide to and an inhibitor of aldehyde dehydrogenase (ALDH) by rat liver microsomes. Alcohol Alcohol Suppl. 1987;1:219-23. Induction of the cytochrome P-450 enzymes by phenobarbital (PB) pretreatment doubled the yield of while SKF-525A blocked this PB-induced increase. |
2(0,0,0,2) | Details |
| 15763964 | Ishihara Y, Shiba D, Shimamoto N: Primary hepatocyte apoptosis is unlikely to relate to caspase-3 activity under sustained endogenous oxidative stress. Free Radic Res. 2005 Feb;39(2):163-73. Pretreatment with either SKF, a cytochrome P450 inhibitor, or an antioxidant, completely suppressed the increase in ROS levels and apoptosis, suggesting that the sustained ROS increases may cause the apoptosis. |
1(0,0,0,1) | Details |
| 10607376 | Fort DJ, Stover EL, Bantle JA, Finch RA: Evaluation of the developmental toxicity of thalidomide using frog embryo teratogenesis assay-xenopus (FETAX): biotransformation and detoxification. Teratog Carcinog Mutagen. 2000;20(1):35-47. Young male Sprague-Dawley rats were treated with either isoniazid or Aroclor 1254 to induce cytochrome P-450. |
1(0,0,0,1) | Details |
| 3790167 | Handler JA, Bradford BU, Glassman E, Ladine JK, Thurman RG: Catalase-dependent metabolism in vivo in deermice lacking alcohol dehydrogenase. Biochem Pharmacol. 1986 Dec 15;35(24):4487-92. Under these conditions, the peroxidatic activity of catalase measured in vitro and the -dependent decrease in catalase-H2O2 in perfused livers also returned to near basal levels; however, the oxidation of by cytochrome P-450 was inhibited completely. |
1(0,0,0,1) | Details |
| 1147963 | de Toranzo EG, Gomez MI, Castro JA: Mechanism of in vivo carbon tetrachloride-induced liver microsomal cytochrome P-450 destruction. Biochem Biophys Res Commun. 1975 Jan 2;64(3):823-8. |
1(0,0,0,1) | Details |
| 10579652 | Huentelman MJ, Peters CM, Ervine WE, Polutnik SM, Johnson P: has differential effects on rat neuron and thymocyte reactive species levels and cell viability. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1999 Sep;124(1):83-9. These parameters in neurons were relatively unaffected when the cells were incubated with in the presence of inhibitors of -oxidizing enzymes, but in thymocytes, the presence of diallyl sulfide (an inhibitor of -inducible cytochrome P450, CYP2E1) or 4-methylpyrazole (an inhibitor of CYP2E1 and alcohol dehydrogenase) caused decreases in ROS production from |
1(0,0,0,1) | Details |
| 14564738 | Shchepetkin IA, Akhmedzhanov RR, Kagiia VT: [Effect of azole derivatives on lucigenin-dependent microsome chemiluminescence]. Biomed Khim. 2003 May-Jun;49(3):278-83. Lucigenin-dependent chemiluminescence cannot be used for measuring the modulating action of agents on reactive species production in the microsomes, but it may be used for luminometrical studies of enzyme complex NAD (P) H-reductases/cytochrome P450 in model systems. |
1(0,0,0,1) | Details |
| 18704327 | Tunctan B, Yaghini FA, Estes A, Malik KU: Prostaglandins inhibit cytochrome P450 4A activity and contribute to endotoxin-induced hypotension in rats via production. Arch Pharm Res. 2008 Jul;31(7):856-65. Epub 2008 Aug 14. |
1(0,0,0,1) | Details |
| 1540380 | Kinnula VL, Whorton AR, Chang LY, Crapo JD: Regulation of peroxide generation in cultured endothelial cells. . Am J Respir Cell Mol Biol. 1992 Feb;6(2):175-82. Endogenous peroxide (H2O2) release from aortic endothelial cells was studied in the presence of antioxidant enzyme inhibitors, mitochondrial inhibitors, a microsomal cytochrome P-450 inhibitor, and after oxidative stress induced with H2O2 or |
1(0,0,0,1) | Details |
| 15868480 | Lamarche F, Gonthier B, Signorini N, Eysseric H, Barret L: Impact of and on DNA and cell viability of cultured neurones. Cell Biol Toxicol. 2004 Nov;20(6):361-74. ROS also reduced viability, but this was observed only after both cytochrome P450 stimulation and catalase inhibition. |
1(0,0,0,1) | Details |