| Name | thyroid stimulating hormone (protein family or complex) |
|---|---|
| Synonyms | Thyroid stimulating hormone |
| Name | amitrole |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 722183 | Freudenthal RI, Kerchner G, Persing R, Baron RL: Dietary subacute toxicity of ethylene thiourea in the laboratory rat. J Environ Pathol Toxicol. 1978 Sep-Oct;1(1):147-61. Marked increases in serum thyroid stimulating hormone (TSH) levels were found in the 625 and 125 ppm ETU rats, the 125 PTU rats, and the rats receiving amitrole, each time this hormone was measured. |
6(0,0,1,1) | Details |
| 3285378 | Paynter OE, Burin GJ, Jaeger RB, Gregorio CA: Goitrogens and thyroid follicular cell neoplasia: evidence for a threshold process. Regul Toxicol Pharmacol. 1988 Mar;8(1):102-19. These include low diets, subtotal thyroidectomy, radioactive natural goitrogens such as rape seed and cabbage, chemotherapeutic agents such as sulfathiazole, and pesticides such as amitrole. Decreased circulating levels of thyroid hormones in the blood result in increased release of thyroid-stimulating hormone by the anterior pituitary gland. |
2(0,0,0,2) | Details |
| 9681970 | Hurley PM: Mode of carcinogenic action of pesticides inducing thyroid follicular cell tumors in rodents. Environ Health Perspect. 1998 Aug;106(8):437-45. Intrathyroidal and extrathyroidal sites of action are found: amitrole, ethylene thiourea, and mancozeb are thyroid peroxidase inhibitors; and acetochlor, clofentezine, fenbuconazole, fipronil, pendimethalin, pentachloronitrobenzene, prodiamine, pyrimethanil, and thiazopyr seem to enhance the hepatic metabolism and excretion of thyroid hormone. Studies on thyroid-pituitary functioning, including indications of thyroid cell growth and/or changes in or thyroid-stimulating hormone levels, are available on 19 pesticides. |
1(0,0,0,1) | Details |
| 16384670 | Imai T, Onose J, Hasumura M, Takizawa T, Hirose M: Indomethacin induces small intestinal damage and inhibits amitrole-associated thyroid carcinogenesis in rats initiated with N-bis (2-hydroxypropyl) nitrosamine. Toxicol Lett. 2006 Jun 20;164(1):71-80. Epub 2005 Dec 27. In experiment 2, rats were similarly fed diet containing AT for 3 weeks with concomitant IM or DSS treatment after a DHPN initiation, and serum thyroid stimulating hormone levels were found to be significantly elevated only in the IM case. |
1(0,0,0,1) | Details |
| 7293669 | Stringer B, Wynford-Thomas D, Jasani B, Williams ED: Effect of goitrogen administration on the circadian rhythm of serum thyroid stimulating hormone in the rat. Acta Endocrinol. 1981 Nov;98(3):396-401. |
1(0,0,0,1) | Details |
| 7842389 | Fregly MJ, Rossi F, Cade JR: A role for thyroid hormones in cold-induced elevation of blood pressure and cardiac hypertrophy. Can J Physiol Pharmacol. 1994 Sep;72(9):1066-74. Serum concentrations of T4 and (T3) in the two treated groups were reduced, while serum thyroid-stimulating hormone concentration and thyroid mass were increased above that of the warm-acclimated control group. |
1(0,0,0,1) | Details |