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Hosoda R, Nakayama K, Kato-Negishi M, Kawahara M, Muramoto K, Kuroda Y: Thyroid hormone enhances the formation of synapses between cultured neurons of rat cerebral cortex. Cell Mol Neurobiol. 2003 Dec;23(6):895-906.
The detection of synaptic vesicle-associated protein synapsin I by immunocytochemical and immunoblot analysis also confirmed that exposure to thyroxine facilitated synapse formation. 4.
The presence of amiodarone, an inhibitor of 5'-deiodinase, or amitrole, a herbicide, inhibited the synapse formation in the presence of thyroxine. 5. |
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