| Name | alcohol dehydrogenase (protein family or complex) |
|---|---|
| Synonyms | ADH; alcohol dehydrogenase; alcohol dehydrogenases |
| Name | amitrole |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 10579652 | Huentelman MJ, Peters CM, Ervine WE, Polutnik SM, Johnson P: has differential effects on rat neuron and thymocyte reactive species levels and cell viability. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1999 Sep;124(1):83-9. These parameters in neurons were relatively unaffected when the cells were incubated with in the presence of inhibitors of -oxidizing enzymes, but in thymocytes, the presence of diallyl sulfide (an inhibitor of -inducible cytochrome P450, CYP2E1) or 4-methylpyrazole (an inhibitor of CYP2E1 and alcohol dehydrogenase) caused decreases in ROS production from |
1(0,0,0,1) | Details |
| 6404112 | Bond AN, Wickramasinghe SN: Investigations into the production of from by human blood and bone marrow cells in vitro. Acta Haematol. 1983;69(5):303-13. The metabolism of by nucleated marrow cells was only slightly inhibited by pyrazole and 3-amino-1,2,4-triazole indicating that it was largely independent of pyrazole-sensitive alcohol dehydrogenase and catalase. |
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| 7018402 | Zahlten RN, Nejtek ME, Jacobson JC: metabolism in guinea pig: in vivo elimination, alcohol dehydrogenase distribution, and subcellular localization of dehydrogenase in liver. Arch Biochem Biophys. 1981 Apr 1;207(2):371-9. |
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| 3390231 | Kato S, Alderman J, Lieber CS: In vivo role of the microsomal -oxidizing system in metabolism by deermice lacking alcohol dehydrogenase. Biochem Pharmacol. 1988 Jul 1;37(13):2706-8. |
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| 17597213 | Jamal M, Ameno K, Uekita I, Kumihashi M, Wang W, Ijiri I: Catalase mediates formation in the striatum of free-moving rats. Neurotoxicology. 2007 Nov;28(6):1245-8. Epub 2007 May 13. Rats received intraperitoneal EtOH (1g/kg) alone or in combination with 4-methylpyrazole (MP, 82 mg/kg, an alcohol dehydrogenase inhibitor), and/or catalase inhibitor azide (AZ, 10mg/kg) or 3-amino-1,2,4-triazole (AT, 1g/kg), and/or cyanamide (CY, 50mg/kg, an aldehyde dehydrogenase inhibitor). |
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| 8536535 | Batra SC, Haber PS, Mirmiran-Yazdy FS, Korsten MA, Gentry RT, Lieber CS: Gastric metabolism of in Syrian golden hamster. Dig Dis Sci. 1995 Dec;40(12):2712-6. In contrast to alcohol dehydrogenase, catalase activity in hamster gastric mucosa (870 +/- 93 units/g tissue) was eightfold higher than in rat gastric mucosa (111 +/- 9 units/g tissue; P < 0.0001). |
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| 3954830 | Wickramasinghe SN: Observations on the biochemical basis of metabolism by human macrophages. Alcohol Alcohol. 1986;21(1):57-63. The metabolism of (0.1 and 1.0 mg/ml) to by blood-monocyte-derived macrophages was only slightly inhibited by pyrazole, 4-iodopyrazole and 3-amino-1,2,4-triazole indicating that it was largely independent of alcohol dehydrogenase and catalase. |
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| 3555347 | Kato S, Alderman J, Lieber CS: Respective roles of the microsomal oxidizing system and catalase in metabolism by deermice lacking alcohol dehydrogenase. Arch Biochem Biophys. 1987 May 1;254(2):586-91. |
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| 3790167 | Handler JA, Bradford BU, Glassman E, Ladine JK, Thurman RG: Catalase-dependent metabolism in vivo in deermice lacking alcohol dehydrogenase. Biochem Pharmacol. 1986 Dec 15;35(24):4487-92. |
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| 241214 | Lieber CS, DeCarli LM, Feinman L, Hasumura Y, Korsten M, Matsuzaki S, Teschke R: Effect of chronic consumption on and metabolism. Adv Exp Med Biol. 1975;59:185-227. Hepatic metabolism of to by the alcohol dehydrogenase (ADH) pathway is associated with the generation of reducing equivalents as |
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| 8489262 | Bradford BU, Seed CB, Handler JA, Forman DT, Thurman RG: Evidence that catalase is a major pathway of oxidation in vivo: dose-response studies in deer mice using as a selective substrate. Arch Biochem Biophys. 1993 May 15;303(1):172-6. In light of these findings it became necessary to reevaluate the role of catalase and alcohol dehydrogenase in metabolism. |
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| 3426685 | Kato S, Alderman J, Lieber CS: metabolism in alcohol dehydrogenase deficient deermice is mediated by the microsomal oxidizing system, not by catalase. Alcohol Alcohol Suppl. 1987;1:231-4. Non-alcohol dehydrogenase (ADH) dependent pathways contribute to in vivo metabolism, but the respective role of each has long been debated. |
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