| Name | xanthine oxidase |
|---|---|
| Synonyms | XDH; XDHA; XO; XOD; XOR; Xanthene dehydrogenase; Xanthine dehydrogenase; Xanthine dehydrogenase/oxidase… |
| Name | amitrole |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9054188 | Cejkova J, Lojda Z: Histochemical study on xanthine oxidase activity in the normal rabbit cornea and lens and after repeated irradiation of the eye with UVB rays. Acta Histochem. 1996 Jan;98(1):47-52. |
8(0,0,0,8) | Details |
| 9140708 | Maenishi O, Ito H, Suzuki T: Acceleration of hypertensive cerebral injury by the inhibition of -xanthine oxidase system in stroke-prone spontaneously hypertensive rats. Clin Exp Hypertens. 1997 May;19(4):461-77. |
4(0,0,0,4) | Details |
| 1567224 | Royall JA, Gwin PD, Parks DA, Freeman BA: Responses of vascular endothelial oxidant metabolism to lipopolysaccharide and tumor necrosis factor-alpha. Arch Biochem Biophys. 1992 May 1;294(2):686-94. We measured basal rates of oxidant production and the activity of xanthine oxidase, proposed to be a key source of O2- and H2O2, in endothelial cells. |
4(0,0,0,4) | Details |
| 8021293 | Hiraishi H, Terano A, Razandi M, Pedram A, Sugimoto T, Harada T, Ivey KJ: Reactive metabolite-induced toxicity to cultured bovine endothelial cells: status of cellular iron in mediating injury. J Cell Physiol. 1994 Jul;160(1):132-4. -51-labeled cells were exposed to reaction mixtures of xanthine oxidase/ and oxidase/ these produce and peroxide, or peroxide, respectively. |
4(0,0,0,4) | Details |
| 2540741 | Jaeschke H, Mitchell JR: Mitochondria and xanthine oxidase both generate reactive species in isolated perfused rat liver after hypoxic injury. Biochem Biophys Res Commun. 1989 Apr 14;160(1):140-7. |
2(0,0,0,2) | Details |
| 3127425 | Brown JM, Terada LS, Grosso MA, Whitmann GJ, Velasco SE, Patt A, Harken AH, Repine JE: Xanthine oxidase produces peroxide which contributes to reperfusion injury of ischemic, isolated, perfused rat hearts. J Clin Invest. 1988 Apr;81(4):1297-301. |
2(0,0,0,2) | Details |
| 8433009 | Karg E, Odh G, Wittbjer A, Rosengren E, Rorsman H: peroxide as an inducer of elevated tyrosinase level in melanoma cells. J Invest Dermatol. 1993 Feb;100(2 Suppl):209S-213S. Exposure of cells to /xanthine oxidase or / oxidase resulted in a dose-related elevation of tyrosinase. |
2(0,0,0,2) | Details |
| 2110780 | McCutchan HJ, Schwappach JR, Enquist EG, Walden DL, Terada LS, Reiss OK, Leff JA, Repine JE: Xanthine oxidase-derived H2O2 contributes to reperfusion injury of ischemic skeletal muscle. Am J Physiol. 1990 May;258(5 Pt 2):H1415-9. |
2(0,0,0,2) | Details |
| 1992789 | Babbs CF, Salaris SC, Turek JJ: Cytochemical studies of peroxide generation in postischemic hepatocytes. Am J Physiol. 1991 Jan;260(1 Pt 2):H123-9. Mean densities of positive peroxisomes per 1,000 micron2 (+/- SE) in liver slices subjected to various treatments were as follows: continuous anoxia (negative control) 0 +/- 0; normoxia + exogenous H2O2 (positive control) 45 +/- 12; normoxia only 26 +/- 2; ischemia-reoxygenation 13 +/- 6; ischemia-reoxygenation + xanthine oxidase inhibitor, 5 +/- 3; ischemia-reoxygenation + peroxidase inhibitor, aminotriazole 7 +/- 3. |
1(0,0,0,1) | Details |
| 7740538 | Hart BA, Prabhu RM, Eneman JD, Durieux-Lu CC, Janssen AM, Borm PJ: Oxidant resistance of cadmium-adapted human lung fibroblasts. . Toxicology. 1995 Apr 12;98(1-3):1-13. Using the /xanthine oxidase system as a generating system for active species, we found that the magnitude of cell injury for Cd-adapted and non-adapted fibroblasts was dependent upon oxidant concentration and duration of oxidant exposure. |
1(0,0,0,1) | Details |
| 2077003 | Engstrom PC, Easterling L, Baker RR, Matalon S: Mechanisms of extracellular peroxide clearance by alveolar type II pneumocytes. J Appl Physiol. 1990 Dec;69(6):2078-84. They were then coincubated with either 500 microM and 10 mU/ml xanthine oxidase (XO; pH 7.4; 25 degrees C) or 300 microM H2O2. |
1(0,0,0,1) | Details |
| 3148110 | Brown JM, Terada LS, Grosso MA, Whitman GJ, Velasco SE, Patt A, Harken AH, Repine JE: peroxide mediates reperfusion injury in the isolated rat heart. . Mol Cell Biochem. 1988 Dec;84(2):173-5. Depletion of xanthine oxidase by two methods or allopurinol inhibition) also improved recovery of function and H2O2 production. |
1(0,0,0,1) | Details |
| 11730782 | Kotze AC, McClure SJ: Haemonchus contortus utilises catalase in defence against exogenous peroxide in vitro. Int J Parasitol. 2001 Dec;31(14):1563-71. Both / oxidase (generation of peroxide) and /xanthine oxidase (generation of systems showed concentration-dependent toxicity to the nematodes. |
1(0,0,0,1) | Details |
| 14564738 | Shchepetkin IA, Akhmedzhanov RR, Kagiia VT: [Effect of azole derivatives on lucigenin-dependent microsome chemiluminescence]. Biomed Khim. 2003 May-Jun;49(3):278-83. Sanazole strongly inhibited the lucigenin-dependent chemiluminescence in the enzyme system of -xanthine oxidase. |
1(0,0,0,1) | Details |
| 17597214 | Domico LM, Cooper KR, Bernard LP, Zeevalk GD: Reactive species generation by the ethylene-bis-dithiocarbamate (EBDC) fungicide mancozeb and its contribution to neuronal toxicity in mesencephalic cells. Neurotoxicology. 2007 Nov;28(6):1079-91. Epub 2007 May 22. In growth medium lacking cells, MZ produced little H (2) O (2), but enhanced H (2) O (2) generation when added with plus xanthine oxidase whereas, in cultured cells, allopurinol partially attenuated H (2) O (2) production by MZ. |
1(0,0,0,1) | Details |
| 8005512 | Kinnula VL, Aalto K, Raivio KO, Walles S, Linnainmaa K: Cytotoxicity of oxidants and asbestos fibers in cultured human mesothelial cells. Free Radic Biol Med. 1994 Feb;16(2):169-76. Immortalized human pleural mesothelial cells (MET 5A) were exposed in vitro to one of the following: (100-200 microM) plus xanthine oxidase (10-20 mU/ml) as a -generating system, H2O2 (50 microM-5 mM); or amosite (1-100 micrograms/cm2). |
1(0,0,0,1) | Details |