Protein Information

Name GSHPx 1
Synonyms Cellular glutathione peroxidase; GPX1; GPx 1; GSHPX1; GSHPx 1; Glutathione peroxidase 1; GPx 1s; GSHPx 1s…

Compound Information

Name amitrole
CAS

Reference List

PubMed Abstract RScore(About this table)
9196400 Spector A, Ma W, Wang RR, Yang Y, Ho YS: The contribution of GSH peroxidase-1, catalase and GSH to the degradation of H2O2 by the mouse lens. Exp Eye Res. 1997 Mar;64(3):477-85.


Utilizing cultured lenses from normal and homozygous glutathione peroxidase (GSHPx-1) knockout mice and inhibitors for GSSG Reductase (GSSG Red), 1,3-bis (2-chlorethyl)-1-nitrosourea (BCNU) and catalase (Cat), 3-aminotriazole (3-AT), the ability to degrade H2O2 was examined at two H2O2 concentrations, 300 microM and 80 microM.
2(0,0,0,2) Details
12775721 Chovolou Y, Watjen W, Kampkotter A, Kahl R: Resistance to tumor necrosis factor-alpha (TNF-alpha)-induced apoptosis in rat hepatoma cells expressing TNF-alpha is linked to low antioxidant enzyme expression. J Biol Chem. 2003 Aug 8;278(32):29626-32. Epub 2003 May 29.


Expression of copper and zinc containing superoxide dismutase was also decreased, whereas expression of glutathione peroxidase-1 was unchanged in Yv2-12 and Yv13-44 cells.
1(0,0,0,1) Details
16274876 Johnson RM, Goyette G Jr, Ravindranath Y, Ho YS: Hemoglobin autoxidation and regulation of endogenous H2O2 levels in erythrocytes. Free Radic Biol Med. 2005 Dec 1;39(11):1407-17. Epub 2005 Aug 24.


Red cells from mice deficient in glutathione peroxidase-1 were used to estimate the hemoglobin autoxidation rate and the endogenous level of H2O2 and superoxide.
1(0,0,0,1) Details