Protein Information

Name glucose 6 phosphate dehydrogenase
Synonyms 6 phosphogluconolactonase; GDH; G6PDH; Glucose 6 phosphate dehydrogenase; GDH/6PGL endoplasmic bifunctional protein; GDH/6PGL endoplasmic bifunctional protein precursor; Glucose 1 dehydrogenase; Glucose dehydrogenase…

Compound Information

Name amitrole
CAS

Reference List

PubMed Abstract RScore(About this table)
14681974 Lushchak OV, Bahniukova TV, Lushchak VI: [Effect of aminotriazole on the activity of catalase and glucose-6-phosphate dehydrogenase in tissues of two frog species--Rana ridibunda and Rana esculenta]. Ukr Biokhim Zh. 2003 Jul-Aug;75(4):45-50.

3(0,0,0,3) Details
7752092 Grossman S, Budinsky R, Jollow D: Dapsone-induced hemolytic anemia: role of glucose-6-phosphate dehydrogenase in the hemolytic response of rat erythrocytes to N-hydroxydapsone. J Pharmacol Exp Ther. 1995 May;273(2):870-7.

2(0,0,0,2) Details
18457571 Bayliak M, Gospodaryov D, Semchyshyn H, Lushchak V: Inhibition of catalase by aminotriazole in vivo results in reduction of glucose-6-phosphate dehydrogenase activity in Saccharomyces cerevisiae cells. Biochemistry. 2008 Apr;73(4):420-6.

2(0,0,0,2) Details
3169364 Antonenkov VD, Panchenko LF: Effect of chronic ethanol treatment under partial catalase inhibition on the activity of enzymes related to peroxide metabolism in rat liver and heart. Int J Biochem. 1988;20(8):823-8.


In order to test the hypothesis that the alcoholic cardiomyopathy under partial catalase inhibition is associated with the activation of lipid peroxidation in cardiomyocytes (Panchenko et al., Experientia 43, 580-581, 1987), the effects of ethanol and catalase inhibitor 3-amino-1,2,4-triazole (aminotriazole) on rat heart and liver content of reduced glutathione and on the activity of enzymes related to peroxide metabolism: catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase, glutathione-S-transferase and glucose-6-phosphate dehydrogenase were investigated. 2.
2(0,0,0,2) Details
1369090 Okuda T, Matsuda Y, Sugawara M, Sagisaka S: Metabolic response to treatment with cold, paraquat, or 3-amino-1,2,4-triazole in leaves of winter wheat. Biosci Biotechnol Biochem. 1992 Dec;56(12):1911-5.


We assayed the activities of glucose-6-phosphate dehydrogenase, catalase, dehydroascorbate reductase and ascorbate free radical reductase and levels of hydrogen peroxide, glucose-6-phosphate, fructose-6-phosphate, ascorbate, dehydroascorbate, reduced and oxidized glutathione.
1(0,0,0,1) Details
3445547 Antonenkov VD, Gusev VA, Krasnova SN: [Effect of ethanol and the catalase inhibitor aminotriazole on the activity of antioxidative enzymes in the rat liver and heart]. Vopr Med Khim. 1987 Nov-Dec;33(6):59-64.


Effect of ethanol and aminotriazole on content of reduced glutathione as well as on activity of catalase, superoxide dismutase, glutathione-S-transferase and glucose-6-phosphate dehydrogenase, the enzymes participating in the antioxidation system, were also studied in liver and heart tissues.
1(0,0,0,1) Details
2367521 Brown JM, White CW, Terada LS, Grosso MA, Shanley PF, Mulvin DW, Banerjee A, Whitman GJ, Harken AH, Repine JE: Interleukin 1 pretreatment decreases ischemia/reperfusion injury. Proc Natl Acad Sci U S A. 1990 Jul;87(13):5026-30.


Hearts isolated from rats treated 36 hr before with interleukin 1 (IL-1) had increased glucose-6-phosphate dehydrogenase (G6PD) activity and decreased hydrogen peroxide levels and injury after global ischemia (I, 20 min)/reperfusion (R, 40 min) compared with hearts from untreated rats.
1(0,0,0,1) Details
2648406 Brown JM, Grosso MA, Terada LS, Whitman GJ, Banerjee A, White CW, Harken AH, Repine JE: Endotoxin pretreatment increases endogenous myocardial catalase activity and decreases ischemia-reperfusion injury of isolated rat hearts. Proc Natl Acad Sci U S A. 1989 Apr;86(7):2516-20.


Hearts isolated from rats pretreated 24 hr before with endotoxin had increased myocardial catalase activity, but the same superoxide dismutase, glutathione peroxidase, glutathione reductase, and glucose-6-phosphate dehydrogenase activities, as hearts from untreated rats.
1(0,0,0,1) Details
16168691 Bagnyukova TV, Storey KB, Lushchak VI: Adaptive response of antioxidant enzymes to catalase inhibition by aminotriazole in goldfish liver and kidney. Comp Biochem Physiol B Biochem Mol Biol. 2005 Nov;142(3):335-41. Epub 2005 Sep 15.


Liver glucose-6-phosphate dehydrogenase activity was reduced at both time points.
1(0,0,0,1) Details