Protein Information

Name p38
Synonyms AIMP 2; p38; AIMP2; JTV 1; JTV1; JTV1 gene; JTV1 protein; Multisynthetase complex auxiliary component p38…

Compound Information

Name amitrole
CAS

Reference List

PubMed Abstract RScore(About this table)
10910949 Chuang SM, Liou GY, Yang JL: Activation of JNK, p38 and ERK mitogen-activated protein kinases by chromium (VI) is mediated through oxidative stress but does not affect cytotoxicity. Carcinogenesis. 2000 Aug;21(8):1491-500.


In this study we have explored the involvement of oxidative stress in Cr (VI)-induced JNK, p38 and ERK signaling pathways and their effects on Cr (VI) cytotoxicity in human non-small cell lung carcinoma CL3 cells.		 5(0,0,0,5) Details
14962975 Carter AB, Tephly LA, Venkataraman S, Oberley LW, Zhang Y, Buettner GR, Spitz DR, Hunninghake GW: High levels of catalase and glutathione peroxidase activity dampen H2O2 signaling in human alveolar macrophages. Am J Respir Cell Mol Biol. 2004 Jul;31(1):43-53. Epub 2004 Feb 12.


Results are presented which support the hypothesis that adequate steady-state levels of hydrogen peroxide (H2O2) are required to overcome the effects of high catalase and glutathione peroxidase (GPx) expression for p38 mitogen-activated protein (MAP) kinase activation and tumor necrosis factor (TNF)-alpha gene expression in human alveolar macrophages stimulated with asbestos.		 3(0,0,0,3) Details