Protein Information

Name transferase
Synonyms 4' phosphopantetheinyl transferase; 4' phosphopantetheinyl transferase; AASD PPT; AASDHPPT; AASDPPT; Alpha aminoadipic semialdehyde dehydrogenase phosphopantetheinyl transferase; Aminoadipate semialdehyde dehydrogenase phosphopantetheinyl transferase; CGI 80…

Compound Information

Name amitrole
CAS

Reference List

PubMed Abstract RScore(About this table)
8250959 Aniya Y, Shimoji M, Naito A: Increase in liver microsomal glutathione S-transferase activity by phenobarbital treatment of rats. Biochem Pharmacol. 1993 Nov 17;46(10):1741-7.


When rats were given phenobarbital (PB) intraperitoneally for 3 days, liver microsomal GSH S-transferase activity was stimulated 1.3-1.4-fold and the effect of PB on the transferase was potentiated by combination with a catalase inhibitor, 3-amino-1,2,4-triazole.
6(0,0,0,6) Details
9931285 Shaikh ZA, Vu TT, Zaman K: Oxidative stress as a mechanism of chronic cadmium-induced hepatotoxicity and renal toxicity and protection by antioxidants. Toxicol Appl Pharmacol. 1999 Feb 1;154(3):256-63.


Serum alanine amino transferase and lactate dehydrogenase activities were elevated after 9 weeks of Cd administration, indicating hepatic damage.
1(0,0,0,1) Details
8221693 Santelli G, de Franciscis V, Portella G, Chiappetta G, D'Alessio A, Califano D, Rosati R, Mineo A, Monaco C, Manzo G, et al.: Production of transgenic mice expressing the Ki-ras oncogene under the control of a thyroglobulin promoter. Cancer Res. 1993 Nov 15;53(22):5523-7.


Transgenic mice have been generated bearing three fusion genes consisting of: (a) a 900-base pair rat thyroglobulin promoter followed by a gene coding for a chloramphenicol acetyl transferase activity; (b) the same promoter followed by the complementary DNA of the human activated Ki-ras oncogene; (c) a 2000-base pair rat thyroglobulin promoter followed by the complementary DNA of the human activated Ki-ras.
1(0,0,0,1) Details
6472331 Tsutsui T, Maizumi H, Barrett JC: Amitrole-induced cell transformation and gene mutations in Syrian hamster embryo cells in culture. Mutat Res. 1984 Aug;140(4):205-7.

Over the dose range that induces morphological transformation of Syrian hamster embryo cells in culture, amitrole induced gene mutations at the Na+/K+ ATPase and hypoxanthine phosphoribosyl transferase loci measured concomitantly in the same cells.
6(0,0,1,1) Details
16407272 Ishihara Y, Shimamoto N: Involvement of endonuclease G in nucleosomal DNA fragmentation under sustained endogenous oxidative stress. J Biol Chem. 2006 Mar 10;281(10):6726-33. Epub 2006 Jan 4.


Treatment with ATZ+MS time-dependently increased the number of deoxynucleotidyl transferase-mediated nick end-labeling (TUNEL)-positive nuclei from 12 h, resulting in clear DNA laddering at 24 h.
1(0,0,0,1) Details
19603180 Yu Q, Abdallah I, Han H, Owen M, Powles S: Distinct non-target site mechanisms endow resistance to glyphosate, ACCase and ALS-inhibiting herbicides in multiple herbicide-resistant Lolium rigidum. Planta. 2009 Sep;230(4):713-23. Epub 2009 Jul 15.


By using the cytochrome P450 inhibitor malathion and amitrole with ALS and ACCase herbicides, respectively, we showed that malathion reverses chlorsulfuron resistance and amitrole reverses diclofop resistance in the R population examined.
0(0,0,0,0) Details
5563869 Lester G: Regulation of tryptophan biosynthetic enzymes in Neurospora crassa. J Bacteriol. 1971 Jul;107(1):193-202.


In the presence of amitrole (3-amino-1,2,4-triazole), the formation of TS activity in a wild-type strain was more greatly enhanced than were AAS and InGPS activities.
0(0,0,0,0) Details