| 16297522 |
Freyberger A, Ahr HJ: Studies on the goitrogenic mechanism of action of N,N,N',N'-tetramethylthiourea. Toxicology. 2006 Jan 16;217(2-3):169-75. Epub 2005 Nov 16.
As thyroid peroxidase (TPO) and type I iodothyronine deiodinase (ID-I) have been established as targets of goitrogenic thiourea derivatives, we investigated interactions of TMTU with target enzymes using a partially purified fraction from hog thyroids or solubilized hog thyroid microsomes and 10,000g supernatant from rat liver homogenate, respectively, as enzyme sources. |
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