| Name | cytochrome P 450 reductase |
|---|---|
| Synonyms | CPR; CYPOR; Cytochrome P 450 reductase; Cytochrome P450 reductase; NADPH cytochrome P450 reductase; NADPH cytochrome P450 reductase; P450 (cytochrome) oxidoreductase; P450R… |
| Name | diquat |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 10838165 | Bayol-Denizot C, Daval JL, Netter P, Minn A: Xenobiotic-mediated production of by primary cultures of rat cerebral endothelial cells, astrocytes, and neurones. Biochim Biophys Acta. 2000 Jun 2;1497(1):115-26. In order to characterise the risk of oxidative stress to both the central nervous system and the blood-brain barrier, we measured in the present work the release of in the culture medium of rat cerebrovascular endothelial cells during the metabolism of anthraquinone, diquat or nitrofurazone. formation by microsomes prepared from the cultured cells was decreased by immunoinhibition of NADPH-cytochrome P450 reductase or by its irreversible inhibition by diphenyliodonium suggesting the involvement of this flavoprotein in radical production. |
1(0,0,0,1) | Details |
| 7575675 | Blakeman DP, Ryan TP, Jolly RA, Petry TW: Diquat-dependent protein carbonyl formation. Biochem Pharmacol. 1995 Sep 28;50(7):929-35. |
0(0,0,0,0) | Details |
| 9488113 | Chat M, Bayol-Denizot C, Suleman G, Roux F, Minn A: Drug metabolizing enzyme activities and formation in primary and immortalized rat brain endothelial cells. Life Sci. 1998;62(2):151-63. The production observed during NADPH-cytochrome P450 reductase-dependent monoelectronic reduction of four xenobiotics, anthraquinone, nitrofurazone and diquat, was also investigated in these cultured cells at confluence. |
82(1,1,1,2) | Details |
| 2384057 | Adam A, Smith LL, Cohen GM: An assessment of the role of redox cycling in mediating the toxicity of paraquat and nitrofurantoin. Environ Health Perspect. 1990 Apr;85:113-7. This was reflected in kinetic studies using lung and liver microsomes, which showed that -cytochrome P-450 reductase had a lower affinity (Km) for paraquat and nitrofurantoin than for and diquat, although values of Vmax were comparable for all the substrates except nitrofurantoin, which was lower. |
81(1,1,1,1) | Details |
| 1654843 | DeGray JA, Rao DN, Mason RP: Reduction of paraquat and related bipyridylium compounds to free radical metabolites by rat hepatocytes. Arch Biochem Biophys. 1991 Aug 15;289(1):145-52. The reduction of paraquat is generally attributed to -cytochrome P-450 reductase, and presumably diquat is also reduced by this flavoprotein. |
31(0,1,1,1) | Details |
| 3421716 | Tsokos-Kuhn JO: Lethal injury by diquat redox cycling in an isolated hepatocyte model. Arch Biochem Biophys. 1988 Sep;265(2):415-24. Specific activities of -cytochrome P-450 reductase in isolated Fischer and Sprague-Dawley rat liver microsomes utilizing 1 mM diquat as acceptor were 0.085 +/- 0.017 and 0.076 +/- 0.028 mumol/mg.min (mean +/- SEM, N = 5), respectively, indicating the capacity for very active redox cycling of diquat by this route in both strains. |
6(0,0,1,1) | Details |