Protein Information

Name lactate dehydrogenase (protein family or complex)
Synonyms LDH; lactate dehydrogenase; lactate dehydrogenases

Compound Information

Name diquat
CAS

Reference List

PubMed Abstract RScore(About this table)
8382845 Rikans LE, Cai Y: Diquat-induced oxidative damage in BCNU-pretreated hepatocytes of mature and old rats. Toxicol Appl Pharmacol. 1993 Feb;118(2):263-70.

The hepatocytes were incubated for 2 hr with 0, 0.5, or 2.0 mM diquat dibromide, and samples were taken at various time points for measurements of glutathione, glutathione disulfide, thiobarbituric acid reactive substances, lactate dehydrogenase leakage, protein sulfhydryl groups, and protein carbonyl groups.
6(0,0,1,1) Details
1320687 Rikans LE, Cai Y: Age-associated enhancement of diquat-induced lipid peroxidation and cytotoxicity in isolated rat hepatocytes. J Pharmacol Exp Ther. 1992 Jul;262(1):271-8.

Hepatocytes of old rats were more sensitive than those of mature rats to diquat-induced cytotoxicity (lactate dehydrogenase release into the medium).
6(0,0,1,1) Details
7299856 Kurisaki E, Nagamori H: A comparative study on the effects of paraquat and diquat on cultured human cells. J Toxicol Sci. 1981 Aug;6(3):203-7.

Paraquat caused slightly higher lactate dehydrogenase activity than did diquat.
6(0,0,1,1) Details
1327553 Jaeschke H, Benzick AE: Pathophysiological consequences of enhanced intracellular superoxide formation in isolated perfused rat liver. Chem Biol Interact. 1992 Sep 14;84(1):55-68.

The presence of the redox-cycling agent diquat in the perfusate (200 microM) increased the basal efflux of glutathione disulfide (GSSG) into bile (2.65 +/- 0.26 nmol GSH-equivalents/min per g liver wt.) and perfusate (0.55 +/- 0.15 nmol/min per g) approximately 10-fold.
Only minor liver injury (release of lactate dehydrogenase activity) was observed.
1(0,0,0,1) Details