| Name | alanine aminotransferase |
|---|---|
| Synonyms | AAT1; AAT1; GPT; ALT 1; ALT1; Alanine aminotransferase; Alanine aminotransferase 1; GPT 1… |
| Name | diquat |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16635020 | Zhang L, Wei W, Xu J, Min F, Wang L, Wang X, Cao S, Tan DX, Qi W, Reiter RJ: Inhibitory effect of on diquat-induced lipid peroxidation in vivo as assessed by the measurement of F2-isoprostanes. J Pineal Res. 2006 May;40(4):326-31. Pretreatment with (20 mg/kg) 30 min before diquat administration resulted in a significant reduction in both tissue and plasma F2-isoprostanes levels, and plasma alanine aminotransferase activity. |
87(1,1,2,2) | Details |
| 10490281 | Fu Y, Cheng WH, Porres JM, Ross DA, Lei XG: Knockout of cellular glutathione peroxidase gene renders mice susceptible to diquat-induced oxidative stress. Free Radic Biol Med. 1999 Sep;27(5-6):605-11. The diquat-induced formations of hepatic F2-isoprostanes in these animals peaked at 1 h and preceded the rise of plasma alanine aminotransferase in the Se-adequate GPX1 (-/-). |
7(0,0,1,2) | Details |
| 19136381 | Hong JY, Lebofsky M, Farhood A, Jaeschke H: Oxidant stress-induced liver injury in vivo: role of apoptosis, oncotic necrosis, and c-Jun NH2-terminal kinase activation. Am J Physiol Gastrointest Liver Physiol. 2009 Mar;296(3):G572-81. Epub 2009 Jan 8. Plasma alanine aminotransferase activities increased from 46+/-4 U/l in controls to 955+/-90 U/l at 6 h after diquat treatment. |
6(0,0,1,1) | Details |
| 10746947 | Gupta S, Husser RC, Geske RS, Welty SE, Smith CV: Sex differences in diquat-induced hepatic necrosis and DNA fragmentation in Fischer 344 rats. Toxicol Sci. 2000 Mar;54(1):203-11. At equal doses of diquat, female F344 rats sustained less hepatic damage than did male rats, as estimated by plasma alanine aminotransferase (ALT) activities after 6 h. |
6(0,0,1,1) | Details |
| 10564541 | Fu Y, Cheng WH, Ross DA, Lei X: Cellular glutathione peroxidase protects mice against lethal oxidative stress induced by various doses of diquat. Proc Soc Exp Biol Med. 1999 Nov;222(2):164-9. Compared with those of surviving mice that were sacrificed on Day 7, the dead GPX1 (-/-) had diquat dose-dependent increases (P < 0.05) in plasma alanine aminotransferase (ALT) activities. |
6(0,0,1,1) | Details |
| 16670937 | Abe T, Kinda T, Takano Y, Chikazawa S, Higuchi M, Kawasaki N, Orino K, Watanabe K: Relationship between body iron stores and diquat toxicity in male Fischer-344 rats. Biometals. 2006 Dec;19(6):651-7. Epub 2006 May 3. Three hours after administration of 0.1 mmol DQ/kg, serum alanine aminotransferase and urea were significantly higher than in controls (saline injection) for both the LIS and HIS groups (P <0.01), and, after DQ injection, these parameters were significantly higher in the HIS group than in the LIS group (P <0.01). |
1(0,0,0,1) | Details |
| 7697743 | Vulimiri SV, Gupta S, Smith CV, Moorthy B, Randerath K: Rapid decreases in indigenous covalent DNA modifications (I-compounds) of male Fischer-344 rat liver DNA by diquat treatment. Chem Biol Interact. 1995 Mar 30;95(1-2):1-16. Two and 6 h later plasma alanine aminotransferase (ALT) activities were measured and hepatic DNA I-compound levels were examined by nuclease P1-enhanced 32P-postlabeling. |
1(0,0,0,1) | Details |
| 17078987 | Rogers LK, Bates CM, Welty SE, Smith CV: Diquat induces renal proximal tubule injury in glutathione reductase-deficient mice. Toxicol Appl Pharmacol. 2006 Dec 15;217(3):289-98. Epub 2006 Sep 26. |
0(0,0,0,0) | Details |