| Name | glutathione peroxidase 1 |
|---|---|
| Synonyms | Cellular glutathione peroxidase; GPX1; GPx 1; GSHPX1; GSHPx 1; Glutathione peroxidase 1; GPx 1s; GSHPx 1s… |
| Name | diquat |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11568445 | Lei XG: Glutathione peroxidase-1 gene knockout on body antioxidant defense in mice. Biofactors. 2001;14(1-4):93-9. After these mice were injected with pro-oxidants paraquat or diquat at 12 to 125 mg/kg of body weight, their survival rate and time were a function of their GPX1 activity levels. |
92(1,1,2,7) | Details |
| 10564541 | Fu Y, Cheng WH, Ross DA, Lei X: Cellular glutathione peroxidase protects mice against lethal oxidative stress induced by various doses of diquat. Proc Soc Exp Biol Med. 1999 Nov;222(2):164-9. In conclusion, normal GPX1 expression is necessary to protect mice against the lethality, hepatic protein oxidation, and elevation of plasma ALT activity induced by 12-48 mg diquat/kg. |
67(0,1,7,7) | Details |
| 11498278 | Fu Y, McCormick CC, Roneker C, Lei XG: Lipopolysaccharide and interferon-gamma-induced production and protein oxidation in mouse peritoneal macrophages are affected by glutathione peroxidase-1 gene knockout. Free Radic Biol Med. 2001 Aug 15;31(4):450-9. Macrophages isolated from both wild-type (WT) and GPX1 knockout (KO) mice were activated by lipopolysaccharide (LPS, 1 microg/ml) and interferon-gamma (IFN, 10 U/ml for 24 or 48 h in the presence or absence of 1 microM diquat (DQ), 250 microM aminoguanidine (AG, an inhibitor of inducible synthase), and (or) 100 microM diethyldithiocarbamate (DETC, an inhibitor of Cu,Zn-SOD). |
35(0,1,1,5) | Details |
| 10490281 | Fu Y, Cheng WH, Porres JM, Ross DA, Lei XG: Knockout of cellular glutathione peroxidase gene renders mice susceptible to diquat-induced oxidative stress. Free Radic Biol Med. 1999 Sep;27(5-6):605-11. |
33(0,0,5,8) | Details |
| 10539768 | Cheng WH, Valentine BA, Lei XG: High levels of dietary do not replace cellular glutathione peroxidase in protecting mice from acute oxidative stress. J Nutr. 1999 Nov;129(11):1951-7. Our objective was to determine whether high levels of dietary replaced the protection of the Se-dependent cellular glutathione peroxidase (GPX1) against paraquat- or diquat-induced acute oxidative stress in mice. |
28(0,0,4,8) | Details |
| 11562367 | Fu Y, Sies H, Lei XG: Opposite roles of -dependent glutathione peroxidase-1 in generator diquat- and -induced apoptosis and signaling. J Biol Chem. 2001 Nov 16;276(46):43004-9. Epub 2001 Sep 18. |
18(0,0,2,8) | Details |
| 18445702 | Han ES, Muller FL, Perez VI, Qi W, Liang H, Xi L, Fu C, Doyle E, Hickey M, Cornell J, Epstein CJ, Roberts LJ, Van Remmen H, Richardson A: The in vivo gene expression signature of oxidative stress. Physiol Genomics. 2008 Jun 12;34(1):112-26. Epub 2008 Apr 29. Therefore, we measured oxidative stress parameters and gene expression alterations (Affymetrix arrays) in the liver caused by elevated reactive species induced in vivo by diquat or by genetic ablation of the major antioxidant enzymes CuZn-superoxide dismutase (Sod1) and glutathione peroxidase-1 (Gpx1). |
6(0,0,1,1) | Details |
| 11672444 | Fu Y, Porres JM, Lei XG: Comparative impacts of glutathione peroxidase-1 gene knockout on oxidative stress induced by reactive and species in mouse hepatocytes. Biochem J. 2001 Nov 1;359(Pt 3):687-95. Our objective was to compare the protection of GPX1 against cytotoxicity of generator diquat (DQ), NO donor S-nitroso-N-acetyl-penicillamine (SNAP) and generator 3-morpholinosydnonimine (SIN-1). |
4(0,0,0,4) | Details |
| 15496407 | Ran Q, Liang H, Gu M, Qi W, Walter CA, Roberts LJ 2nd, Herman B, Richardson A, Van Remmen H: Transgenic mice overexpressing glutathione peroxidase 4 are protected against oxidative stress-induced apoptosis. J Biol Chem. 2004 Dec 31;279(53):55137-46. Epub 2004 Oct 20. Cell death induced by t-butylhydroperoxide and diquat was significantly less in murine embryonic fibroblasts from Tg (GPX4) mice compared with wild type mice. |
0(0,0,0,0) | Details |