Protein Information

Name selenoprotein P
Synonyms SELP; SEP; SEPP 1; SEPP1; Selenoprotein P; Selenoprotein P plasma 1; Selenoprotein P precursor; Selenoprotein Ps…

Compound Information

Name diquat
CAS

Reference List

PubMed Abstract RScore(About this table)
9315311 Hill KE, Burk RF: Selenoprotein P: recent studies in rats and in humans. Biomed Environ Sci. 1997 Sep;10(2-3):198-208.

Using selenium-deficient rats supplemented with selenium, it was demonstrated that selenoprotein P appearance correlated with disappearance of diquat-induced lipid peroxidation.
10(0,0,1,5) Details
7843731 Burk RF, Hill KE, Awad JA, Morrow JD, Kato T, Cockell KA, Lyons PR: Pathogenesis of diquat-induced liver necrosis in selenium-deficient rats: assessment of the roles of lipid peroxidation and selenoprotein P. Hepatology. 1995 Feb;21(2):561-9.
8(0,0,1,3) Details
10333732 Burk RF, Hill KE: Orphan selenoproteins. Bioessays. 1999 Mar;21(3):231-7.

Plasma concentration of selenoprotein P correlates with protection against diquat liver injury, suggesting that the protein protects against oxidant injury.
7(0,0,1,2) Details
11232641 Atkinson JB, Hill KE, Burk RF: Centrilobular endothelial cell injury by diquat in the selenium-deficient rat liver. Lab Invest. 2001 Feb;81(2):193-200.

We postulate that selenoprotein P protects the centrilobular endothelial cells against injury by oxidant molecules that result from diquat administration.
7(0,0,1,2) Details
16011466 Burk RF, Hill KE: Selenoprotein P: an extracellular protein with unique physical characteristics and a role in selenium homeostasis. Annu Rev Nutr. 2005;25:215-35.

Selenoprotein P binds to endothelial cells in the rat, and plasma levels of the protein correlate with prevention of diquat-induced lipid peroxidation and hepatic endothelial cell injury.
39(0,1,1,9) Details
7931697 Burk RF, Hill KE: Selenoprotein P. J Nutr. 1994 Oct;124(10):1891-7.

Selenoprotein P is postulated to serve as an extracellular oxidant defense because its presence correlates with selenium protection of selenium-deficient rats against diquat-induced lipid peroxidation and liver necrosis.
13(0,0,1,8) Details
12730456 Burk RF, Hill KE, Motley AK: Selenoprotein metabolism and function: evidence for more than one function for selenoprotein P. J Nutr. 2003 May;133(5 Suppl 1):1517S-20S.

Selenium-dependent protection against diquat-induced liver necrosis and lipid peroxidation in the rat correlates with the presence of selenoprotein P.
11(0,0,1,6) Details