| Name | transferase |
|---|---|
| Synonyms | 4' phosphopantetheinyl transferase; 4' phosphopantetheinyl transferase; AASD PPT; AASDHPPT; AASDPPT; Alpha aminoadipic semialdehyde dehydrogenase phosphopantetheinyl transferase; Aminoadipate semialdehyde dehydrogenase phosphopantetheinyl transferase; CGI 80… |
| Name | diquat |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 7676460 | Gallagher EP, Buetler TM, Stapleton PL, Wang C, Stahl DL, Eaton DL: The effects of diquat and ciprofibrate on mRNA expression and catalytic activities of hepatic xenobiotic metabolizing and antioxidant enzymes in rat liver. Toxicol Appl Pharmacol. 1995 Sep;134(1):81-91. We examined the effects of diquat (0.1 mmol/kg, ip) and ciprofibrate (0.025% w/w, diet), chemicals which induce oxidative stress via different biochemical mechanisms, on the steady-state messenger RNA (mRNA) levels of six cytochrome P450 enzymes, seven glutathione S-transferase (GST) isoenzymes, UDP-glucuronosyl transferase 1-06 (UGT1*06), gamma-glutamylcysteine synthetase (gamma GCS), (H):quinone oxidoreductase (quinone reductase), Cu/Zn superoxide dismutase (SOD), catalase, and 18S ribosomal RNA in the livers of male Sprague-Dawley rats. |
6(0,0,1,1) | Details |
| 8934631 | Cramer CT, Cooke S, Ginsberg LC, Kletzien RF, Stapleton SR, Ulrich RG: Upregulation of glucose-6-phosphate dehydrogenase in response to hepatocellular oxidative stress: studies with diquat. J Biochem Toxicol. 1995 Dec;10(6):293-8. The possibility that diquat increased transcription by transfecting cells with a chimeric gene containing 935 bp of the G6PDH promoter (-878 to +57) linked to the gene for chloramphenicol acetyl-transferase (CAT) was examined. |
81(1,1,1,1) | Details |
| 19136381 | Hong JY, Lebofsky M, Farhood A, Jaeschke H: Oxidant stress-induced liver injury in vivo: role of apoptosis, oncotic necrosis, and c-Jun NH2-terminal kinase activation. Am J Physiol Gastrointest Liver Physiol. 2009 Mar;296(3):G572-81. Epub 2009 Jan 8. To verify these findings in vivo, male Fisher rats were treated with diquat and DNA strandbreaks, evaluated with the terminal deoxynucleotidyl transferase-mediated nick-end labeling (TUNEL) assay, showed clusters of TUNEL-positive cells, where the staining was predominantly cytosolic and the cells were swollen, indicating oncotic necrosis. |
1(0,0,0,1) | Details |
| 12215683 | Rogers LK, Gupta S, Welty SE, Hansen TN, Smith CV: Nuclear and nucleolar glutathione reductase, peroxidase, and transferase activities in livers of male and female Fischer-344 rats. Toxicol Sci. 2002 Sep;69(1):279-85. The present studies were to test the hypotheses that glutathione reductase (GR), peroxidase (GPX), and glutathione S-transferase (GST) activities are expressed in nuclei and nucleoli of rat liver cells, and that differences in activities of these enzymes would correlate with the greater resistance of female than of male Fischer-344 rats to hepatic necrosis in vivo, mediated by reactive species generated by redox-cycling metabolism of diquat. |
1(0,0,0,1) | Details |