Protein Information

Name AHAS
Synonyms 209L8; AHAS; Acetolactate synthase; Acetolactate synthase homolog; ILV2H; ILVB like; ILVBL; IlvB (Bacterial acetolactate synthase) like isoform 1 variant…

Compound Information

Name chlorimuron
CAS 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid

Reference List

PubMed Abstract RScore(About this table)
12496246 Pang SS, Guddat LW, Duggleby RG: Molecular basis of sulfonylurea herbicide inhibition of acetohydroxyacid synthase. J Biol Chem. 2003 Feb 28;278(9):7639-44. Epub 2002 Dec 20.

Here we report the 2.8 A resolution crystal structure of yeast AHAS in complex with a sulfonylurea herbicide, chlorimuron ethyl.
82(1,1,1,2) Details
16127072 Boigegrain RA, Liautard JP, Kohler S: Targeting of the virulence factor acetohydroxyacid synthase by sulfonylureas results in inhibition of intramacrophagic multiplication of Brucella suis. Antimicrob Agents Chemother. 2005 Sep;49(9):3922-5.

The acetohydroxyacid synthase (AHAS) of Brucella suis can be effectively targeted by the sulfonylureas chlorimuron ethyl and metsulfuron methyl.
82(1,1,1,2) Details
14684914 Pang SS, Guddat LW, Duggleby RG: Crystallization of Arabidopsis thaliana acetohydroxyacid synthase in complex with the sulfonylurea herbicide chlorimuron ethyl. Acta Crystallogr D Biol Crystallogr. 2004 Jan;60(Pt 1):153-5. Epub 2003 Dec 18.

Here, the crystallization and preliminary X-ray diffraction analysis of the catalytic subunit of Arabidopsis thaliana AHAS in complex with the sulfonylurea herbicide chlorimuron ethyl are reported.
82(1,1,1,2) Details
9794808 Hill CM, Duggleby RG: Mutagenesis of Escherichia coli acetohydroxyacid synthase isoenzyme II and characterization of three herbicide-insensitive forms. Biochem J. 1998 Nov 1;335 ( Pt 3):653-61.

A plasmid containing the large and small subunit genes of AHAS II was mutagenized using hydroxylamine and clones resistant to the sulphonylurea chlorimuron ethyl were selected.
9(0,0,1,4) Details
15709745 McCourt JA, Pang SS, Guddat LW, Duggleby RG: Elucidating the specificity of binding of sulfonylurea herbicides to acetohydroxyacid synthase. Biochemistry. 2005 Feb 22;44(7):2330-8.


Acetohydroxyacid synthase (AHAS, EC 2.2.1.6) is the target for the sulfonylurea herbicides, which act as potent inhibitors of the enzyme.
4(0,0,0,4) Details