| Name | CYP2E1 |
|---|---|
| Synonyms | CPE 1; Flavoprotein linked monooxygenase; Xenobiotic monooxygenase; Microsomal monooxygenase; CPE1; CYP2E; CYP2E1; CYP2E1 protein… |
| Name | cyanamide |
|---|---|
| CAS | cyanamide |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 10528996 | Hammond AH, Fry JR: Effect of cyanamide on toxicity and depletion in rat hepatocyte cultures: differences between two dichloropropanol isomers. Chem Biol Interact. 1999 Sep 30;122(2):107-15. Induction of CYP2E1 also potentiated the toxicity of 2,3-dichloropropanol, and in these cultures cyanamide pre-treatment significantly increased both toxicity and depletion. |
7(0,0,1,2) | Details |
| 8861782 | Khan S, Sood C, O'Brien PJ: The involvement of cytochrome P4502E1 in 2-bromoethanol-induced hepatocyte cytotoxicity. Pharmacol Toxicol. 1996 Apr;78(4):241-8. Furthermore, aldehyde dehydrogenase inhibitors-cyanamide or chloral hydrate increased 2-bromoethanol dependent hepatocyte susceptibility. However, cytochrome P4502E1 (CYP2E1) inhibitors/substrates were more effective at preventing 2-bromoethanol-induced GSH depletion, lipid peroxidation and cytotoxicity suggesting that 2-bromoethanol is mostly metabolically activated by CYP2E1. |
4(0,0,0,4) | Details |
| 10573527 | Roman J, Colell A, Blasco C, Caballeria J, Pares A, Rodes J, Fernandez-Checa JC: Differential role of and in the induction of oxidative stress in HEP G2 cells: effect on transcription factors AP-1 and NF-kappaB. Hepatology. 1999 Dec;30(6):1473-80. The oxidative metabolism of by the cytochrome P450 2E1 (CYP2E1) has been recognized to contribute to the -induced deleterious effects through the induction of oxidative stress. activated NF-kappaB and AP-1 in E47 cells, an effect that was prevented by 4-methylpyrazole, potentiated by cyanamide, and attenuated by trolox C. |
2(0,0,0,2) | Details |