| Name | Aldehyde dehydrogenases (protein family or complex) |
|---|---|
| Synonyms | aldehyde dehydrogenase; aldehyde dehydrogenases |
| Name | cyanamide |
|---|---|
| CAS | cyanamide |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 2619564 | Zimatkin SM: [Structural changes in the rat cerebral cortex induced by in combination with aldehyde dehydrogenase inhibitors]. Arkh Anat Gistol Embriol. 1989 Oct;97(10):13-20. The cerebral parietal cortex in rats subjected to an acute (single) and subacute (for 5 days) effect in combination with aldehyde dehydrogenase (AldDG) (enzymes classification 1.2.1.3 AldDG) inhibitors--disulfiram and cyanamide--has been investigated histochemically and electron microscopically. |
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| 9113267 | Hartley DP, Petersen DR: Co-metabolism of -derived and in isolated rat hepatocytes. Alcohol Clin Exp Res. 1997 Apr;21(2):298-304. To determine further if 4-HNE and are metabolized through the same metabolic pathways, cells were preincubated with either 4-methylpyrazole or cyanamide to inhibit alcohol dehydrogenase (E.C. 1.1.1.1.) and aldehyde dehydrogenase (E.C. 1.2.1.2.), respectively. |
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| 2764709 | Vasiliou V, Marselos M: Changes in the inducibility of a hepatic aldehyde dehydrogenase by various effectors. Arch Toxicol. 1989;63(3):221-5. A hepatic soluble aldehyde dehydrogenase (ALDH), inducible by polycyclic aromatic hydrocarbons, was studied in Wistar rats in connection with substances known to affect drug metabolism or aldehyde dehydrogenase activity, such as phenobarbital (PB), disulfiram (DS), beta-diethylaminoethyl diphenylpropylacetate (SKF 525A) and cyanamide (CC). 3-Methylcholanthrene (MC) was given as a model inducer of ALDH (100 mg/kg, i.p., as a single dose) and the animals were killed after 3 days. |
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| 10514271 | Conway TT, DeMaster EG, Goon DJ, Shirota FN, Nagasawa HT: Diethylcarbamoylating/nitroxylating agents as dual action inhibitors of aldehyde dehydrogenase: a disulfiram-cyanamide merger. J Med Chem. 1999 Oct 7;42(20):4016-20. |
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| 15670664 | You M, Crabb DW: Molecular mechanisms of alcoholic fatty liver: role of sterol regulatory element-binding proteins. Alcohol. 2004 Aug;34(1):39-43. Whereas inhibition of oxidation by 4-methylpyrazole blocked the effect, the aldehyde dehydrogenase inhibitor cyanamide enhanced the effect of in the hepatoma cells, supporting the idea that the effect is likely mediated by |
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| 3384064 | Ali F, Persaud TV: Mechanisms of fetal alcohol effects: role of . Exp Pathol. 1988;33(1):17-21. Pregnant rats were treated from day 9 through 12 of gestation with 12.5% 25% 1% cyanamide (an inhibitor of the enzyme aldehyde dehydrogenase), or a combination of cyanamide and |
31(0,1,1,1) | Details |
| 15623782 | Choudhary S, Xiao T, Vergara LA, Srivastava S, Nees D, Piatigorsky J, Ansari NH: Role of aldehyde dehydrogenase isozymes in the defense of rat lens and human lens epithelial cells against oxidative stress. Invest Ophthalmol Vis Sci. 2005 Jan;46(1):259-67. RESULTS: Rat lenses transfected with ALDH1A1-specific SiRNA, or cultured in the presence of the ALDH inhibitor cyanamide/disulfiram and subjected to oxidative stress displayed accelerated loss of transparency and a diminished capacity to oxidize HNE. |
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| 3977944 | Anderson RA Jr, Quigg JM, Oswald C, Zaneveld LJ: Demonstration of a functional blood-testis barrier to Biochem Pharmacol. 1985 Mar 1;34(5):685-95. This functional blood-testis barrier to could be explained by testicular aldehyde dehydrogenases in the mitochondria (Km for = 1.5 microM) and in the cytosol (Km = 123 microM) whose maximal activities totaled to more than 25-fold greater than that of testicular alcohol dehydrogenase (ADH). Pargyline (100 mg/kg) or cyanamide (8.4 mg/kg) increased (P less than 0.05) plasma and testicular while having no effect on the response to |
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| 1987314 | Zimatkin SM: Histochemical study of aldehyde dehydrogenase in the rat CNS. J Neurochem. 1991 Jan;56(1):1-11. |
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| 6347204 | Dawson AG: oxidation in systems containing soluble and mitochondrial fractions of rat liver. Biochem Pharmacol. 1983 Jul 15;32(14):2157-65. Mitochondria, because of their relatively high aldehyde dehydrogenase (ALDH) activity, prevented the accumulation of or quickly removed already accumulated. Cyanamide, an inhibitor of mitochondrial ALDH, blocked the stimulatory effect of mitochondria on oxidation. |
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| 8986222 | Fujimiya T, Li YJ, Uemura K, Ohbora Y, Komura S: Noncompetitive-like inhibition of elimination by cyanamide treatment: pharmacokinetic study. Alcohol Clin Exp Res. 1996 Dec;20(9 Suppl):278A-283A. We examined the pharmacokinetic mechanism of the inhibition of metabolism by cyanamide, an inhibitor of mitochondrial aldehyde dehydrogenase. |
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| 10826131 | Colom H, Prunonosa J, Peraire C, Domenech J, Azcona O, Torrent J, Obach R: Absolute bioavailability and absorption profile of cyanamide in man. J Pharmacokinet Biopharm. 1999 Aug;27(4):421-36. A pharmacokinetic study of cyanamide, an inhibitor of aldehyde dehydrogenase (EC1.2.1.3) used as an adjuvant in the aversive therapy of chronic alcoholism, has been carried out in healthy male volunteers following intravenous and oral administration. |
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| 1418657 | Nagasawa HT, Lee MJ, Kwon CH, Shirota FN, DeMaster EG: An N-hydroxylated derivative of cyanamide that inhibits yeast aldehyde dehydrogenase. Alcohol. 1992 Sep-Oct;9(5):349-53. |
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| 11095510 | Kinoshita H, Jessop DS, Finn DP, Coventry TL, Roberts DJ, Ameno K, Ijiri I, Harbuz MS: Acute decreases NPY mRNA but not POMC mRNA in the arcuate nucleus. . Neuroreport. 2000 Nov 9;11(16):3517-9. was increased in blood following with cyanamide (a potent inhibitor of aldehyde dehydrogenase) administration. |
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| 6753841 | DeMaster EG, Kaplan E, Shirota FN, Nagasawa HT: Metabolic activation of cyanamide by liver mitochondria, a requirement for the inhibition of aldehyde dehydrogenase enzymes. Biochem Biophys Res Commun. 1982 Aug 31;107(4):1333-9. |
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| 7894532 | Pronko P, Zimatkin S, Kuzmich A: Effect of aldehyde dehydrogenase and alcohol dehydrogenase inhibitors and on blood and liver ketone bodies in the rat. Pol J Pharmacol. 1994 Sep-Oct;46(5):445-9. The effects of the aldehyde dehydrogenase (ALDH) inhibitors: cyanamide (CY) and disulfiram (DS) and the alcohol dehydrogenase (ADH) inhibitor, pyrazole (PY) and the combination of these drugs with (ET, 3.5 g/kg, ip 6 h before decapitation) on the concentrations of rat blood and liver ketone bodies were studied. |
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| 10680717 | Shoeman DW, Shirota FN, DeMaster EG, Nagasawa HT: Reaction of an aldehyde dehydrogenase inhibitor, with N-acetyl- Alcohol. 2000 Jan;20(1):55-9. (HNO) is the aldehyde dehydrogenase (AIDH) inhibitor produced by catalase action on cyanamide. |
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| 12850777 | Adachi J, Kudo R, Nushida H, Ueno Y, Koll M, Preedy VR: Fatty acid profile in skeletal muscle of the rat in response to acute (2.5 hours) and prolonged (6 weeks) -dosage. Addict Biol. 2003 Jun;8(2):181-9. There were four groups: (A) saline (control); (B) cyanamide (an aldehyde dehydrogenase inhibitor); (C) and (D) cyanamide + |
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| 11022051 | Galli A, Pinaire J, Fischer M, Dorris R, Crabb DW: The transcriptional and DNA binding activity of peroxisome proliferator-activated receptor alpha is inhibited by metabolism. J Biol Chem. 2001 Jan 5;276(1):68-75. This effect of was abolished by the alcohol dehydrogenase inhibitor 4-methylpyrazole and augmented by the aldehyde dehydrogenase inhibitor cyanamide, indicating that was responsible for the action of |
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| 3620014 | Spivak K, Aragon CM, Amit Z: Alterations in brain aldehyde dehydrogenase activity modify the locomotor effects produced by in rats. Alcohol Drug Res. 1987;7(5-6):481-91. Cyanamide, an ALDH inhibitor elevates blood levels in the presence of |
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| 6391253 | Stowell A, Johnsen J, Aune H, Vatne K, Ripel A, Morland J: A reinvestigation of the usefulness of breath analysis in the determination of blood concentrations. Alcohol Clin Exp Res. 1984 Sep-Oct;8(5):442-7. They were also given (0.2 g/kg) intravenous 4 hr after receiving a dose of 50 mg citrated carbimide, an aldehyde dehydrogenase inhibitor. |
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| 18272654 | Huellner MW, Schrepfer S, Weyand M, Weiner H, Wimplinger I, Eschenhagen T, Rau T: Inhibition of aldehyde dehydrogenase type 2 attenuates vasodilatory action of nitroglycerin in human veins. FASEB J. 2008 Jul;22(7):2561-8. Epub 2008 Feb 13. In vitro contraction experiments were performed in the presence or absence of the ALDH inhibitors chloral hydrate, cyanamide, and ethoxycyclopropanol. |
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| 1416058 | Gilani S, Persaud TV: Embryonic development in the chick following exposure to and cyanamide. Ann Anat. 1992 Aug;174(4):305-8. The influence of cyanamide, an inhibitor of aldehyde dehydrogenase, on the embryopathic effects of and was investigated in the chick embryo. |
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| 7136724 | Tottmar O, Hellstrom E, Holmberg K, Lindros KO: Effects of dopamine-beta-hydroxylase inhibitors FLA-57 and FLA-63 on metabolism and aldehyde dehydrogenase activity in rats. Acta Pharmacol Toxicol. 1982 Sep;51(3):198-202. FLA-63 inhibited the low-Km enzyme in vitro, but much less than the ALDH-inhibitors disulfiram and cyanamide. |
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| 707135 | Marchner H, Tottmar O: A comparative study on the effects of disulfiram, cyanamide and 1-aminocyclopropanol on the metabolism in rats. Acta Pharmacol Toxicol. 1978 Sep;43(3):219-32. 1-aminocyclopropanol (ACP) is a potent inhibitor of aldehyde dehydrogenase (ALDH) in vivo and in vitro. |
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| 18317950 | Vary TC, Lang CH: Differential phosphorylation of translation initiation regulators 4EBP1, S6k1, and Erk 1/2 following inhibition of metabolism in mouse heart. Cardiovasc Toxicol. 2008 Mar;8(1):23-32. Epub 2008 Mar 4. Pretreatment with cyanamide, an inhibitor of aldehyde dehydrogenase, did not attenuate the -induced decrease in phosphorylation S6k1 (389)), but partially prevented the -induced lowering of 4EBP1 phosphorylation. The studies indicate that modulation of metabolism through inhibition of ADH or aldehyde dehydrogenase leads to preferential modulation of the phosphorylation of distinct myocardial signaling systems involved in regulating protein synthesis. |
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| 10715166 | Cohen JF, Elberling JA, DeMaster EG, Lin RC, Nagasawa HT: N-Terminal dipeptides of D (-)-penicillamine as sequestration agents for J Med Chem. 2000 Mar 9;43(5):1029-33. The presence of cyanamide (an inhibitor of aldehyde dehydrogenase) in the incubation medium resulted in a 45-fold increase in -derived AcH; nevertheless, dipeptides 6a and 6c (D-penicillamyl- were able to reduce this AcH level by approximately one-third. The presence of cyanamide (an inhibitor of aldehyde dehydrogenase) in the incubation medium resulted in a 45-fold increase in -derived AcH; nevertheless, dipeptides 6a and 6c (D-penicillamyl- were able to reduce this AcH level by approximately one-third. |
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| 10723960 | Ijiri I: [Biological actions of . Nihon Hoigaku Zasshi. 1999 Nov;53(3):285-95. After pretreatment with cyanamide (CY), a potent inhibitor of aldehyde dehydrogenase, or pyrazole (PY), a potent inhibitor of alcohol dehydrogenase, a 17% EtOH solution (0.4 g/kg) was administered into the jejunum segment, and 150 min after the administration of EtOH, the fluid from the segment was collected to determine its volume and EtOH concentration. |
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| 11524301 | Kinoshita H, Ijiri I, Ameno S, Kubota T, Zhang X, Hishida S, Ameno K: Cholinergic nerves mediate action in the gastrointestinal tract. Alcohol Alcohol. 2001 Sep-Oct;36(5):377-80. We used atropine (AT), atropine methylbromide (ATMB), pirenzepine (PI), bethanechol (BE) and pilocarpine (PL) with or without cyanamide (CY; a potent inhibitor of aldehyde dehydrogenase, which induces high AcH concentration in blood). |
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| 9191964 | Shirota FN, Stevens-Johnk JM, DeMaster EG, Nagasawa HT: Novel prodrugs of cyanamide that inhibit aldehyde dehydrogenase in vivo. J Med Chem. 1997 Jun 6;40(12):1870-5. |
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| 564706 | Tottmar O, Marchner H, Karlsson N: The presence of an aldehyde dehydrogenase inhibitor in animal diets and its effects on the experimental results in studies. Br J Nutr. 1978 Mar;39(2):317-24. The effects of chronic administration on the metabolism of and were studied in rats fed on a commercial diet containing an aldehyde dehydrogenase inhibitor, cyanamide carbimide), as a contaminant in the calcinated bone-meal fraction of the diet. 2. |
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| 4041987 | Brien JF, Tam GS, Cameron RJ, Steenaart NA, Loomis CW: A comparative study of the inhibition of hepatic aldehyde dehydrogenases in the rat by methyltetrazolethiol, carbimide, and disulfiram. Can J Physiol Pharmacol. 1985 May;63(5):438-43. The time course of MTT-induced inhibition of hepatic aldehyde dehydrogenases (ALDH) was determined in adult, male Sprague-Dawley rats in comparison with the hepatic ALDH inhibition induced by carbimide cyanamide, CC) and disulfiram (D). |
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| 12655465 | Escarabajal MD, De Witte P, Quertemont E: Role of in -induced conditioned taste aversion in rats. Psychopharmacology. 2003 May;167(2):130-6. Epub 2003 Mar 25. In a second experiment, cyanamide, an aldehyde dehydrogenase inhibitor, was administered before conditioning with either or to investigate the effects of accumulation. |
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| 6686442 | Korsten MA, Gordon ER, Klingenstein J, Lieber CS: Effects of chronic feeding and metabolism on transport by rat liver mitochondria. Biochem Biophys Res Commun. 1983 Nov 30;117(1):169-75. The in vitro actions of appear to be mediated, in part, by its metabolism in mitochondria since pretreatment of rats with cyanamide (an aldehyde dehydrogenase inhibitor) prevents this effect. |
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| 3966800 | Svanas GW, Weiner H: Aldehyde dehydrogenase activity as the rate-limiting factor for metabolism in rat liver. Arch Biochem Biophys. 1985 Jan;236(1):36-46. To confirm that ALDH activity was the rate-limiting factor, low-Km ALDH in slices or intact mitochondria was partially inhibited by treatment with cyanamide and the rate of metabolism measured. |
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| 14690875 | Quintanilla ME, Tampier L: Brain mitochondrial aldehyde dehydrogenase: relation to aversion in low--drinking (UChA) and high--drinking (UChB) rats. Addict Biol. 2003 Dec;8(4):387-97. In experiment 2, the possibility that the inhibition of the brain ALDH2 would lower the AcH aversion threshold in both lines was studied by determining the effect of cyanamide (10 mg/kg i.p.) pretreatment, an inhibitor of ALDH, on AcH aversion, blood AcH levels and brain ALDH2 activity. |
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| 3801056 | Jaeschke H, Kleinwaechter C, Wendel A: The role of acrolein in allyl -induced lipid peroxidation and liver cell damage in mice. Biochem Pharmacol. 1987 Jan 1;36(1):51-7. In vivo-inhibition of alcohol dehydrogenase by pyrazole or induction of aldehyde dehydrogenase by phenobarbital abolished AA-induced liver damage as well as depletion and lipid peroxidation, while inhibition of aldehyde dehydrogenase by cyanamide made a subtoxic dose of AA (0.60 mmol/kg) highly toxic. |
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| 12217933 | Kinoshita H, Jessop DS, Roberts DJ, Ameno K, Ijiri I, Hishida S, Harbuz MS: Effects of on c-fos mRNA induction in the paraventricular nucleus following administration. Alcohol Alcohol. 2002 Sep-Oct;37(5):432-5. METHODS: Increases in concentrations were induced using cyanamide (a potent inhibitor of aldehyde dehydrogenase), in the presence of two different doses of |
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| 3342079 | DeMaster EG, Stevens JM: Acute effects of the aldehyde dehydrogenase inhibitors, disulfiram, pargyline and cyanamide, on circulating ketone body levels in the rat. Biochem Pharmacol. 1988 Jan 15;37(2):229-34. |
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| 7424727 | Sinclair JD, Lindros KO, Terho K: Aldehyde dehydrogenase inhibitors and voluntary drinking by rats. Adv Exp Med Biol. 1980;132:481-7. Aldehyde dehydrogenase (ALDH) inhibitors, cyanamide (200 mg or 40 mg/kg food) and coprine (N5-(hydroxycyclopropyl)- 500 mg/kg food), strongly suppressed, with similar time courses, the free-choice consumption of 10% v/v |
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| 4062972 | Eriksson CJ: Endogenous in rats. Biochem Pharmacol. 1985 Nov 15;34(22):3979-82. Male Long-Evans rats consumed the and aldehyde dehydrogenase inhibitors pyrazole, cyanamide or disulfiram, for 6 days. |
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| 15034202 | Aberle NS 2nd, Picklo MJ Sr, Amarnath V, Ren J: Inhibition of cardiac myocyte contraction by 4--trans-2-nonenal. Cardiovasc Toxicol. 2004;4(1):21-8. Interestingly, the HNE-induced cardiac mechanical effects (with the exception of shortened time-PS) were abolished by either the aldehyde dehydrogenase inhibitor cyanamide or the p38 mitogen-activated protein kinase inhibitor SB203580. |
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| 1449559 | Preedy VR, Keating JW, Peters TJ: The acute effects of and on rates of protein synthesis in type I and type II fibre-rich skeletal muscles of the rat. Alcohol Alcohol. 1992 May;27(3):241-51. Young rats were injected with either (75 mmol/kg), (2.8 mmol/kg) or isovolumetric amounts of NaCl (0.15 mol/l, i.e. controls) with or without inhibitors of alcohol dehydrogenase (4-methylpyrazole) or aldehyde dehydrogenase (cyanamide). |
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| 8861782 | Khan S, Sood C, O'Brien PJ: The involvement of cytochrome P4502E1 in 2-bromoethanol-induced hepatocyte cytotoxicity. Pharmacol Toxicol. 1996 Apr;78(4):241-8. Furthermore, aldehyde dehydrogenase inhibitors-cyanamide or chloral hydrate increased 2-bromoethanol dependent hepatocyte susceptibility. |
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| 15288585 | de la Lande IS, Stepien JM, Philpott AC, Hughes PA, Stafford I, Horowitz JD: Aldehyde dehydrogenase, synthase and in ex vivo tolerance in rat aorta. Eur J Pharmacol. 2004 Aug 2;496(1-3):141-9. ALDH inhibitors, chloral hydrate (0.3 mM) and cyanamide (0.1-1 mM) inhibited relaxation to glyceryl trinitrate in non-tolerant and tolerant arteries. |
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| 18445101 | Tampier L, Quintanilla ME, Israel Y: Tolerance to disulfiram induced by chronic intake in the rat. Alcohol Clin Exp Res. 2008 Jun;32(6):937-41. Epub 2008 Apr 26. BACKGROUND: Disulfiram, an inhibitor of aldehyde dehydrogenase used in the treatment of alcoholism, is an effective medication when its intake is supervised by a third person. Subsequently, animals in both groups were administered disulfiram or cyanamide (another inhibitor of aldehyde dehydrogenase) and intake in this free choice paradigm was determined. |
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| 1008896 | Deitrich RA, Troxell PA, Worth WS: Inhibition of aldehyde dehydrogenase in brain and liver by cyanamide. Biochem Pharmacol. 1976 Dec 15;25(24):2733-7. |
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| 1472315 | Gapstur SM, DeMaster EG, Potter JD, Belcher JD, Gross MD: The formation of stable -hemoglobin adducts in a red blood cell model. Alcohol. 1992 Nov-Dec;9(6):563-9. The rapid disappearance of due to oxidation by RBC aldehyde dehydrogenase was prevented by pretreating the cells with the inhibitor cyanamide. |
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| 518666 | Kitson TM, Crow KE: Studies on possible mechanisms for the interaction between cyanamide and aldehyde dehydrogenase. Biochem Pharmacol. 1979 Sep 1;28(17):2551-6. |
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| 8442888 | Myers RD, Lankford M, Bjork A: Irreversible suppression of drinking in cyanamide-treated rats after sustained delivery of the 5-HT2 antagonist amperozide. Alcohol. 1993 Mar-Apr;10(2):117-25. Preference for first was induced pharmacologically in Sprague-Dawley rats by the inhibitor of aldehyde dehydrogenase, cyanamide, administered in a dose of 10 mg/kg twice daily for 3 days. |
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| 12960514 | Jamal M, Ameno K, Ameno S, Okada N, Ijiri I: In vivo study of produced by a high concentration of in the striatum and nucleus accumbens of free-moving rats. Alcohol Clin Exp Res. 2003 Aug;27(8 Suppl):79S-84S. METHODS: After the insertion of a microdialysis probe, male Wistar rats (250-300 g) were treated with cyanamide (CY, a potent aldehyde dehydrogenase inhibitor) + (EtOH), CY + 4-methylpyrazole (4-MP, a strong alcohol dehydrogenase inhibitor) + EtOH, 4-MP + EtOH, CY, and 4-MP. |
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| 7243831 | Eriksson CJ, Deitrich RA: Evidence against a biphasic effect of on voluntary consumption in rats. Pharmacol Biochem Behav. 1980;13 Suppl 1:291-6. One group received the aldehyde dehydrogenase inhibitor, cyanamide, in their diet and an oral dose of 2 g/kg for 5 days. |
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| 8332634 | Myers RD, Lankford MF, Bjork A: 5-HT2 receptor blockade by amperozide suppresses drinking in genetically preferring rats. Pharmacol Biochem Behav. 1993 Jul;45(3):741-7. Previously, it was shown that the unique diphenylbutylpiperazinecarboxamide derivative, amperozide (FG 5606), inhibits the volitional drinking of induced in the rat by the inhibitor of aldehyde dehydrogenase, cyanamide. |
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| 8032311 | Fujita M, Sano M, Yoshino K, Tomita I: Effects of aldehyde dehydrogenase and on the degradation of (E)- and N-hexanal in rat liver. Biochem Mol Biol Int. 1994 Mar;32(3):429-34. When lipid peroxidation was induced by t-butyl hydroperoxide, the ratio of HA to 4HN production in the liver of rats pretreated with the ALDH inhibitor, cyanamide (100 mg/kg, i.p.) was higher than that in controls, whereas the ratio was lower in the liver of rats pretreated with the -depleting agent, phorone (250 mg/kg, i.p.). |
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| 1472305 | Barwick VS, Myers RD: Age dependent development of drinking in rats after inhibition of aldehyde dehydrogenase. Alcohol. 1992 Nov-Dec;9(6):501-7. To induce preference for the AlDH inhibitor, cyanamide, was administered to male Sprague-Dawley rats which were 30 days of age. |
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| 10416267 | Stanek JJ, Morris JB: The effect of inhibition of aldehyde dehydrogenase on nasal uptake of inspired Toxicol Sci. 1999 Jun;49(2):225-31. To provide such information, uptake of inspired was measured at an inspiratory flow rate that approximated the minute ventilation rate in the surgically isolated nasal cavity of F 344 rats pretreated with either saline (control) or the ALDH inhibitor, cyanamide (10 mg/kg s.c.). |
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| 8507395 | Singh GK, Kalmus GW, Bjork AK, Myers RD: drinking in rats is attenuated by the mixed 5-HT1 agonist/5-HT2 antagonist FG 5893. Alcohol. 1993 May-Jun;10(3):243-8. To induce preference for in Sprague-Dawley rats, the enzyme aldehyde dehydrogenase was inhibited by cyanamide administered in the absence of in a dose of 10 mg/kg twice a day over three days. |
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| 3021086 | Bruguera M, Lamar C, Bernet M, Rodes J: Hepatic disease associated with ground-glass inclusions in hepatocytes after cyanamide therapy. Arch Pathol Lab Med. 1986 Oct;110(10):906-10. The use of cyanamide (Colme), an inhibitor of aldehyde dehydrogenase could be documented in 11 instances. |
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| 9714321 | DeMaster EG, Redfern B, Nagasawa HT: Mechanisms of inhibition of aldehyde dehydrogenase by the active metabolite of the deterrent agent cyanamide. Biochem Pharmacol. 1998 Jun 15;55(12):2007-15. |
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| 3508430 | Younes M, Strubelt O: -induced hepatotoxicity: a role for free radicals. Free Radic Res Commun. 1987;3(1-5):19-26. Inhibition of alcohol dehydrogenase by 4-methylpyrazole or of aldehyde dehydrogenase by cyanamide totally abolished hepatotoxicity despite of a severalfold increase in concentration in the perfusate. |
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| 9539382 | West MW, Biggs TA, Tavares E, Lankford MF, Myers RD: Drinking patterns in genetic low--drinking (LAD) rats after systemic cyanamide and cerebral injections of THP or 6-OHDA. Alcohol. 1998 Apr;15(3):239-47. Then a saline vehicle or either 10 or 20 mg/kg of the aldehyde dehydrogenase (AIDH) inhibitor, cyanamide, was injected s.c. twice daily for 3 days. |
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| 3570159 | Volentine GD, Ogden KA, Kortje DK, Tuma DJ, Sorrell MF: Role of in the -induced impairment of hepatic glycoprotein secretion in the rat in vivo. Hepatology. 1987 May-Jun;7(3):490-5. This study used cyanamide, an aldehyde dehydrogenase inhibitor, to correlate enhanced levels with an increased -induced inhibition of hepatic protein secretion. |
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| 7162223 | Jarbe TU, Hiltunen AJ, Swedberg MD: as a discriminative stimulus: effects of cyanamide, and chlormethiazole. Med Biol. 1982 Dec;60(6):298-306. and a combination of cyanamide, an aldehyde dehydrogenase inhibitor, plus ETOH were tested to determine if augmented levels of would enhance ETOH-like responses. |
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| 19719790 | Closon C, Didone V, Tirelli E, Quertemont E: and the hypothermic effects of in mice. Alcohol Clin Exp Res. 2009 Nov;33(11):2005-14. Epub 2009 Aug 31. Experiment 2 tested the effects of a pretreatment with the aldehyde dehydrogenase (ALDH) inhibitor cyanamide (25 mg/kg) on - and -induced hypothermia. |
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| 525358 | Tottmar O, Hellstrom E: Blood pressure response to in relation to levels and dopamine-beta-hydroxylase activity in rats pretreated with disulfiram, cyanamide and coprine. Acta Pharmacol Toxicol. 1979 Oct;45(4):272-81. The blood pressure response after administration was studied in relation to blood levels, aldehyde-dehydrogenase (ALDH)--and dopamine-beta-hydroxylase (DBH) activities in rats pretreated with the -sensitizing compounds disulfiram, cyanamide and coprine and the DBH-inhibitor FLA-57. |
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| 14630370 | Jamal M, Ameno K, Kumihashi M, Ameno S, Kubota T, Wang W, Ijiri I: Microdialysis for the determination of and concentrations in the striatum of freely moving rats. J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Dec 5;798(1):155-8. Rats were treated with cyanamide (100mg/kg, a potent aldehyde dehydrogenase inhibitor) and 60 min later with EtOH (1g/kg) intraperitoneally. |
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| 14573760 | DiFabio J, Ji Y, Vasiliou V, Thatcher GR, Bennett BM: Role of mitochondrial aldehyde dehydrogenase in tolerance. Mol Pharmacol. 2003 Nov;64(5):1109-16. To investigate the role of this enzyme in GTN tolerance, cumulative GTN concentration-response curves were obtained for both GTN-tolerant and -nontolerant rat aortic rings treated with the ALDH inhibitor cyanamide or the ALDH substrate |
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| 1913679 | Kalechman Y, Barkai IS, Albeck M, Horwith G, Sehagl SN, Sredni B: Use and mechanism of action of AS101 in protecting bone marrow colony forming units-granulocyte-macrophage following purging with ASTA-Z 7557. Cancer Res. 1991 Oct 15;51(20):5614-20. We show that AS101 protection from the toxic effects of ASTA-Z in vitro and CTX in vivo can be partially ascribed to increased aldehyde dehydrogenase (ALDH) activity induced by AS101. This was shown directly by measuring cellular ALDH activity and indirectly by measuring the toxicity of ASTA-Z and CTX in the presence of cyanamide, an inhibitor of ALDH. |
1(0,0,0,1) | Details |
| 8435094 | Khan S, Sood C, O'Brien PJ: Molecular mechanisms of dibromoalkane cytotoxicity in isolated rat hepatocytes. Biochem Pharmacol. 1993 Jan 26;45(2):439-47. Furthermore, hepatocyte susceptibility to dibromoalkanes was increased markedly if aldehyde dehydrogenase was inactivated with disulfiram, cyanamide or chloral hydrate. |
81(1,1,1,1) | Details |
| 3426683 | Shirota FN, DeMaster EG, Kwon CH, Nagasawa HT: Metabolism of cyanamide to and an inhibitor of aldehyde dehydrogenase (ALDH) by rat liver microsomes. Alcohol Alcohol Suppl. 1987;1:219-23. |
81(1,1,1,1) | Details |
| 6992725 | Lamboeuf Y, De Saint Blanquat G: Effects of cyanamide and clofibrate on the enzymes of oxydation and on consumption in the rat. Arch Int Pharmacodyn Ther. 1980 Jan;243(1):17-26. Both substances reduce consumption by about 35% and cause metabolic modifications: inhibition of aldehyde dehydrogenase and of catalase by cyanamide; activation of - and aldehyde-dehydrogenases by clofibrate. |
81(1,1,1,1) | Details |
| 3772041 | Sano M, Motchnik PA, Tappel AL: Halogenated hydrocarbon and hydroperoxide-induced peroxidation in rat tissue slices. J Free Radic Biol Med. 1986;2(1):41-8. Treatment of rats with cyanamide, an aldehyde dehydrogenase inhibitor, increased the total CHDRS in liver slices and medium after incubation with BHP or BrCCl3. |
31(0,1,1,1) | Details |
| 14691387 | Niemela O, Parkkila S, Worrall S, Emery PW, Preedy VR: Generation of -derived protein modifications in -exposed heart. Alcohol Clin Exp Res. 2003 Dec;27(12):1987-92. Specimens of heart tissue were obtained from rats after intraperitoneal injections with (75 mmol/kg body weight) with or without pretreatment with cyanamide (0.05 mmol/kg body weight), an aldehyde dehydrogenase inhibitor. |
31(0,1,1,1) | Details |
| 17045751 | Jamal M, Ameno K, Ameno S, Morishita J, Wang W, Kumihashi M, Ikuo U, Miki T, Ijiri I: Changes in cholinergic function in the frontal cortex and hippocampus of rat exposed to and Neuroscience. 2007 Jan 5;144(1):232-8. Epub 2006 Oct 11. The control group was treated with 0.9% saline, and other groups received EtOH or cyanamide (CY, 50 mg/kg, a potent aldehyde dehydrogenase inhibitor) and 60 min later by EtOH intraperitoneally. |
31(0,1,1,1) | Details |
| 11835630 | Burcham PC, Fontaine F: Extensive protein carbonylation precedes acrolein-mediated cell death in mouse hepatocytes. J Biochem Mol Toxicol. 2001;15(6):309-16. Conversely, cyanamide, an aldehyde dehydrogenase inhibitor, enhanced cytotoxicity and protein carbonylation. |
31(0,1,1,1) | Details |
| 11337982 | Adachi J, Asano M, Ueno Y, Marway JS, Camilleri PM, Peters TJ, Preedy VR: Acute effect of on 7-hydroperoxycholesterol in muscle and liver. . Lipids. 2001 Mar;36(3):267-71. We tested the hypotheses that sensitivities of muscle and liver can be discerned in the initial periods of exposure, especially when levels are markedly raised with cyanamide, an aldehyde dehydrogenase inhibitor. |
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| 11981770 | Clemens DL, Forman A, Jerrells TR, Sorrell MF, Tuma DJ: Relationship between levels and cell survival in -metabolizing hepatoma cells. Hepatology. 2002 May;35(5):1196-204. Furthermore, treatment of -metabolizing VA cells with the aldehyde dehydrogenase inhibitor, cyanamide, increased the levels of and resulted in an additional reduction in cell number. |
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| 1932606 | Obach R, Torrent J, Colom H, Prunonosa J, Peraire C, Domenech J: Pharmacokinetics and oral bioavailability of carbimide in man. Biopharm Drug Dispos. 1991 Aug-Sep;12(6):425-34. A pharmacokinetic study of carbimide, an inhibitor of aldehyde dehydrogenase, used as an adjuvant in the aversive therapy of chronic alcoholism, has been carried out in male human volunteers for intravenous and oral administration. |
1(0,0,0,1) | Details |
| 11139417 | Kinoshita H, Jessop DS, Finn DP, Coventry TL, Roberts DJ, Ameno K, Jiri I, Harbuz MS: a metabolite of activates the hypothalamic-pituitary- axis in the rat. Alcohol Alcohol. 2001 Jan-Feb;36(1):59-64. Cyanamide is a potent inhibitor of aldehyde dehydrogenase (ALDH: EC 1.2.1.3) used in the treatment of alcoholics. |
81(1,1,1,1) | Details |
| 10718921 | Kinoshita H, Jessop DS, Finn DP, Harbuz MS: Cyanamide-induced activation of the hypothalamo-pituitary- axis. J Neuroendocrinol. 2000 Mar;12(3):255-62. The present study investigated the effects of acute administration of cyanamide (a potent inhibitor of aldehyde dehydrogenase used to treat alcoholics), on the hypothalamo-pituitary (HPA)-axis. |
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| 9615272 | Altomare E, Grattagliano I, Didonna D, Gentile A, Vendemiale G: Gastric and intestinal toxicity in the rat. Ital J Gastroenterol Hepatol. 1998 Feb;30(1):82-90. Cimetidine and cyanamide inhibited by 50% the activity of alcohol dehydrogenase and by 80% aldehyde dehydrogenase, respectively, in the gastric and intestinal mucosa. |
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| 3761311 | Kwon CH, Nagasawa HT, DeMaster EG, Shirota FN: Acyl, N-protected alpha-aminoacyl, and peptidyl derivatives as prodrug forms of the deterrent agent cyanamide. J Med Chem. 1986 Oct;29(10):1922-9. Cyanamide (H2NC identical to N), a potent aldehyde dehydrogenase (AlDH) inhibitor that is used therapeutically as an deterrent agent, is known to be rapidly metabolized and excreted in the urine as acetylcyanamide (1). |
31(0,1,1,1) | Details |
| 1845547 | Lin RC, Lumeng L: Formation of the 37KD liver protein- adduct in vivo and in vitro. Alcohol Alcohol Suppl. 1991;1:265-9. However, under certain circumstances e.g. when fed an -containing liquid diet supplemented with cyanamide (an aldehyde dehydrogenase inhibitor that raises blood concentrations), this 37KD protein- adduct (protein-AA) becomes incorporated into liver plasma membranes. |
31(0,1,1,1) | Details |
| 2264608 | Lin RC, Lumeng L: Formation of the 37KD protein- adduct in liver during treatment is dependent on alcohol dehydrogenase activity. Alcohol Clin Exp Res. 1990 Oct;14(5):766-70. In this report, we have examined the effects of pyrazole (an ADH inhibitor) and cyanamide (an aldehyde dehydrogenase inhibitor) on the formation of the 37KD liver protein-AA in vivo and in vitro. |
31(0,1,1,1) | Details |
| 8135858 | Nikiforov AA, Ostretsova IB: Stimulatory effect of on weak organic acid uptake in rat renal tubules. Biochem Pharmacol. 1994 Mar 2;47(5):821-5. The stimulation of fluorescein uptake by (20 mM) was abolished by an inhibitor of alcohol dehydrogenase (EC 1.1.1.1), pyrazole (1 mM), or an inhibitor of aldehyde dehydrogenase (EC 1.2.1.3), cyanamide (0.3 mM), suggesting that oxidation of mediated its effect on the uptake. |
31(0,1,1,1) | Details |
| 1608302 | Hu ML, Tappel AL: and antioxidants protect microsomes against lipid peroxidation and enzyme inactivation. Lipids. 1992 Jan;27(1):42-5. The study investigated the relationship between lipid peroxidation and enzyme inactivation in rat hepatic microsomes and whether prior inactivation of aldehyde dehydrogenase (ALDH) exacerbated inactivation of other enzymes. Inhibition of ALDH by cyanamide injection of rats exacerbated the inactivation of G6Pase in microsomes incubated with 0.1 mM, but not 25 microM (4-HN). 4-HN did not stimulate lipid peroxidation. |
1(0,0,0,1) | Details |
| 3702591 | Guerri C, Sanchis R: and in rat's milk following administration. Life Sci. 1986 Apr 28;38(17):1543-56. A significant decrease in mammary tissue aldehyde dehydrogenase was found in chronic alcoholic rats. The time course of and concentration in blood and milk were determined in normal lactating rats after cyanamide (40 mg/kg) and administration (2 or 4 g/kg). |
1(0,0,0,1) | Details |
| 4040375 | DeMaster EG, Shirota FN, Nagasawa HT: Catalase mediated conversion of cyanamide to an inhibitor of aldehyde dehydrogenase. Alcohol. 1985 Jan-Feb;2(1):117-21. |
324(4,4,4,4) | Details |
| 6861004 | Loomis CW, Brien JF: Specificity of hepatic aldehyde dehydrogenase inhibition by carbimide cyanamide) in the rat. Can J Physiol Pharmacol. 1983 Apr;61(4):431-5. |
163(2,2,2,3) | Details |
| 3360115 | Tarasov IuA, Satanovskaia VI, Shishkin SN, Ostrovskii IuM: [Effect of cyanamide on the level of endogenous in the liver of normal rats and in hypocorticism]. Farmakol Toksikol. 1988 Jan-Feb;51(1):80-3. The rat liver endogenous level was found to increase under inhibition of aldehyde dehydrogenases by cyanamide. |
81(1,1,1,1) | Details |
| 4023431 | Nakatsukasa H, Watanabe A, Kobayashi M, Hobara N, Fujiwara M, Yamauchi Y, Shiota T, Higashi T, Nagashima H: Effects of high hepatic level following simultaneous administration of and cyanamide on liver function in rats. Res Exp Med. 1985;185(3):221-5. Extremely high concentrations of hepatic were induced in rats by the intragastric administration of and cyanamide, an aldehyde dehydrogenase inhibitor; and these high levels were maintained for 4 weeks. |
31(0,1,1,1) | Details |
| 15781050 | Jamal M, Ameno K, Wang W, Kumihashi M, Ameno S, Ikuo U, Shinji A, Ijiri I: Inhibition of metabolism decreases release in medial frontal cortex of freely moving rats. Brain Res. 2005 Mar 28;1039(1-2):90-6. Rats were treated intraperitoneally with saline, EtOH (1 and 2 g/kg) or cyanamide (CY, 50 mg/kg, a potent aldehyde dehydrogenase inhibitor) plus EtOH (1 and 2 g/kg). |
31(0,1,1,1) | Details |
| 17597213 | Jamal M, Ameno K, Uekita I, Kumihashi M, Wang W, Ijiri I: Catalase mediates formation in the striatum of free-moving rats. Neurotoxicology. 2007 Nov;28(6):1245-8. Epub 2007 May 13. Rats received intraperitoneal EtOH (1g/kg) alone or in combination with 4-methylpyrazole (MP, 82 mg/kg, an alcohol dehydrogenase inhibitor), and/or catalase inhibitor azide (AZ, 10mg/kg) or 3-amino-1,2,4-triazole (AT, 1g/kg), and/or cyanamide (CY, 50mg/kg, an aldehyde dehydrogenase inhibitor). |
31(0,1,1,1) | Details |
| 11782879 | Koll M, Ahmed S, Mantle D, Donohue TM, Palmer TN, Simanowski UA, Seltz HK, Peters TJ, Preedy VR: Effect of acute and chronic treatment and their superimposition on lysosomal, cytoplasmic, and proteosomal protease activities in rat skeletal muscle in vivo. Metabolism. 2002 Jan;51(1):97-104. Other studies included administration of cyanamide (aldehyde dehydrogenase inhibitor) in vivo or addition of and to muscle preparations in vitro. |
31(0,1,1,1) | Details |
| 11900810 | Escarabajal MD, Aragon CM: The effect of cyanamide and 4-methylpyrazole on the -induced locomotor activity in mice. Pharmacol Biochem Behav. 2002 May;72(1-2):389-95. These data might suggest some influence of brain catalase and aldehyde dehydrogenase (ALDH) on the effects of |
1(0,0,0,1) | Details |
| 3426682 | Jones AW, Neiman J, Hillbom M: Elimination kinetics of and in healthy men during the carbimide-alcohol flush reaction. Alcohol Alcohol Suppl. 1987;1:213-7. The disposition kinetics of were markedly different when aldehyde dehydrogenase (ALDH) was inhibited. |
1(0,0,0,1) | Details |
| 1820876 | Obach R, Prunonosa J, Torrent J, Colom H, Peraire C, Izquierdo I, Domenech J: Lack of correlation between pharmacokinetic and pharmacodynamic behaviour of cyanamide in man. Eur J Drug Metab Pharmacokinet. 1991;Spec No 3:185-90. A pharmacokinetic and dynamic study of cyanamide, an inhibitor of aldehyde dehydrogenase (ALDH) used as an adjuvant in the aversive therapy of chronic alcoholism, has been carried out in man after oral administrations. |
1(0,0,0,1) | Details |
| 3994742 | Svanas GW, Weiner H: Enzymatic requirement for cyanamide inactivation of rat liver aldehyde dehydrogenase. Biochem Pharmacol. 1985 Apr 15;34(8):1197-204. |
162(2,2,2,2) | Details |
| 6378202 | DeMaster EG, Shirota FN, Nagasawa HT: The metabolic activation of cyanamide to an inhibitor of aldehyde dehydrogenase is catalyzed by catalase. Biochem Biophys Res Commun. 1984 Jul 18;122(1):358-65. |
162(2,2,2,2) | Details |
| 10978654 | Kinoshita H, Harbuz MS, Jessop DS, Finn DP, Ameno S, Ameno K, Kubota T, Ijiri I: Hypothalamo-pituitary- axis activation by administration of cyanamide: a potent inhibitor of aldehyde dehydrogenase. Forensic Sci Int. 2000 Sep 11;113(1-3):397-402. |
162(2,2,2,2) | Details |
| 6634840 | Demaster EG, Nagasawa HT, Shirota FN: Metabolic activation of cyanamide to an inhibitor of aldehyde dehydrogenase in vitro. Pharmacol Biochem Behav. 1983;18 Suppl 1:273-7. |
162(2,2,2,2) | Details |
| 7159468 | Hellstrom E, Tottmar O: Effects of aldehyde dehydrogenase inhibitors on enzymes involved in the metabolism of biogenic aldehydes in rat liver and brain. Biochem Pharmacol. 1982 Dec 1;31(23):3899-905. The effects of the aldehyde dehydrogenase inhibitors disulfiram, coprine and cyanamide on enzymes involved in the metabolism of biogenic aldehydes in rat liver and brain were studied. |
64(0,2,2,4) | Details |
| 2735948 | Prunonosa J, Sagrista ML, Bozal J: Inactivation of low-Km rat liver mitochondrial aldehyde dehydrogenase by cyanamide in vitro. Biochem Pharmacol. 1989 Jul 1;38(13):2099-105. |
62(0,2,2,2) | Details |
| 1680656 | Prunonosa J, Sagrista ML, Bozal J: Inactivation mechanism of low-KM rat liver mitochondrial aldehyde dehydrogenase by cyanamide in vitro. Drug Metab Dispos. 1991 Jul-Aug;19(4):787-92. |
62(0,2,2,2) | Details |
| 8218960 | Prunonosa Piera J, Obach R, Sagrista ML, Bozal J: Inhibition of rat hepatic mitochondrial aldehyde dehydrogenase isozymes by repeated cyanamide administration: pharmacokinetic-pharmacodynamic relationships. Biopharm Drug Dispos. 1993 Jul;14(5):419-28. |
62(0,2,2,2) | Details |
| 6870943 | Marchner H, Tottmar O: Studies in vitro on the inactivation of mitochondrial rat-liver aldehyde dehydrogenase by the -sensitizing compounds cyanamide, 1-aminocyclopropanol and disulfiram. Biochem Pharmacol. 1983 Jul 15;32(14):2181-8. |
62(0,2,2,2) | Details |
| 11583712 | Srivastava S, Conklin DJ, Liu SQ, Prakash N, Boor PJ, Srivastava SK, Bhatnagar A: Identification of biochemical pathways for the metabolism of oxidized low-density lipoprotein derived -4- trans-2-nonenal in vascular smooth muscle cells. Atherosclerosis. 2001 Oct;158(2):339-50. The formation of HNA was inhibited by cyanamide, indicating that the acid is derived from an aldehyde dehydrogenase (ALDH)-catalyzed pathway. |
31(0,1,1,1) | Details |
| 2596853 | Silva JM, O'Brien PJ: Allyl - and acrolein-induced toxicity in isolated rat hepatocytes. . Arch Biochem Biophys. 1989 Dec;275(2):551-8. However, cytotoxicity of both allyl and acrolein was enhanced by the aldehyde dehydrogenase inhibitors cyanamide and disulfiram. |
31(0,1,1,1) | Details |
| 6536295 | Svanas GW, Weiner H: Identification of aldehyde dehydrogenase resistant to cyanamide and disulfiram inhibition. Alcohol. 1984 Jul-Aug;1(4):347-9. |
31(0,1,1,1) | Details |
| 15365691 | Jamal M, Ameno K, Kumihashi M, Wang W, Ameno S, Kubota T, Ijiri I: Failure of and to alter in vivo release in the striatum and hippocampus of rats. Arch Toxicol. 2004 Dec;78(12):723-7. Epub 2004 Sep 8. Rats were treated intraperitoneally with EtOH (1 g/kg) or cyanamide (CY, 50 mg/kg, a potent aldehyde dehydrogenase inhibitor) plus EtOH (1 g/kg). |
31(0,1,1,1) | Details |
| 2272522 | Rikans LE, Snowden CD, Moore DR: Influence of aging on and oxidation in female rat liver. Gerontology. 1990;36(4):185-92. On the other hand, rates of metabolism by mitochondrial aldehyde dehydrogenase (ALDH) were 15-20% lower in livers of old rats than in those of younger ones. Results with the ALDH inhibitor cyanamide indicated that a decline in ALDH activity of this magnitude would not increase acute hepatotoxicity. |
1(0,0,0,1) | Details |
| 3358883 | Jones AW, Neiman J, Hillbom M: Concentration-time profiles of and in human volunteers treated with the -sensitizing drug, carbimide. Br J Clin Pharmacol. 1988 Feb;25(2):213-21. This dose of was given 2 h after they swallowed a tablet of either carbimide CC (50 mg), a potent inhibitor of low Km aldehyde dehydrogenase (ALDH), or placebo according to a single-blind crossover design. 2. |
1(0,0,0,1) | Details |
| 2886311 | Rikans LE: The oxidation of acrolein by rat liver aldehyde dehydrogenases. Drug Metab Dispos. 1987 May-Jun;15(3):356-62. The effect of aldehyde dehydrogenase inhibition on allyl toxicity was determined by pretreating rats with cyanamide or disulfiram prior to treatment with allyl |
117(1,2,2,7) | Details |
| 6742849 | Dicker E, Cederbaum AI: Effect of and cyanamide on the metabolism of by hepatocytes, mitochondria, and soluble supernatant from rat liver. Arch Biochem Biophys. 1984 Jul;232(1):179-88. To estimate the roles played by each enzyme in metabolism by rat hepatocytes, experiments with and cyanamide, a potent inhibitor of the low-Km aldehyde dehydrogenase were carried out. |
113(1,2,2,3) | Details |
| 8778744 | Beck O, Helander A, Carlsson S, Borg S: Changes in metabolism during treatment with the aldehyde dehydrogenase inhibitors disulfiram and cyanamide. Pharmacol Toxicol. 1995 Nov;77(5):323-6. |
62(0,2,2,2) | Details |
| 3089300 | Dicker E, Cederbaum AI: Inhibition of CO2 production from aminopyrine or by cyanamide or crotonaldehyde and the role of mitochondrial aldehyde dehydrogenase in oxidation. Biochim Biophys Acta. 1986 Aug 6;883(1):91-7. |
62(0,2,2,2) | Details |
| 4063385 | Dicker E, Cederbaum AI: Inhibition of mitochondrial aldehyde dehydrogenase and oxidation by the -depleting agents diethylmaleate and phorone. Biochim Biophys Acta. 1985 Nov 22;843(1-2):107-13. Thus, diethylmaleate blocks the oxidation of added or metabolically generated analogous to results with other inhibitors of the low-Km aldehyde dehydrogenase such as cyanamide. |
36(0,1,1,6) | Details |
| 2932116 | Ryle PR, Chakraborty J, Thomson AD: The roles of the hepatocellular redox state and the hepatic concentration in determining the elimination rate in fasted rats. Biochem Pharmacol. 1985 Oct 1;34(19):3577-83. Pretreatment of animals with the aldehyde dehydrogenase inhibitor, cyanamide (1 mg/kg or 15 mg/kg p.o. one hour before caused increases of up to 23-fold in the hepatic level, without influencing the cytosolic NAD+:NADH ratio in dosed rats, while significantly reducing the elimination rate by up to 44%, compared with controls. |
31(0,1,1,1) | Details |
| 3663401 | Solomon LR: Evidence for the generation of transaminase inhibitor (s) during metabolism by rat liver homogenates: a potential mechanism for toxicity. Biochem Med Metab Biol. 1987 Aug;38(1):9-18. Cyanamide, an aldehyde dehydrogenase inhibitor, had little effect on -mediated transaminase inhibition. |
31(0,1,1,1) | Details |
| 16540368 | Gyamfi MA, Wan YJ: The effect of metabolizing enzyme inhibitors, and on regulating glutathione S-transferase, and in mouse primary hepatocyte. Hepatol Res. 2006 May;35(1):53-61. Epub 2006 Mar 15. Lipid peroxidation (LPO), assessed by the thiobarbituric acid assay, increased to 221% of control by and was potentiated by cyanamide, an aldehyde dehydrogenase inhibitor. |
31(0,1,1,1) | Details |
| 12701047 | Bonner AB, Dalwai S, Marway JS, Preedy VR: Acute exposure to the nutritional toxin reduces brain protein synthesis in vivo. Metabolism. 2003 Apr;52(4):389-96. In the event that some regions were refractory to the deleterious effects of we also predosed rats with cyanamide, an aldehyde dehydrogenase inhibitor (ie, cyanamide + to increase endogenous a potent agent. |
31(0,1,1,1) | Details |
| 2371231 | Lundquist F, Iversen HL, Hansen LL: Deuterium D (V/K) isotope effects on oxidation in hepatocytes: importance of the reverse ADH-reaction. Pharmacol Toxicol. 1990 Apr;66(4):244-51. The different response of pig and rat hepatocytes to addition of (the effect') is suggested to be caused by differences in activity of aldehyde dehydrogenases in the two species. and cyanamide caused the concentration during oxidation to increase by entirely different mechanisms, and the isotope effect to decrease with time, as did also the addition of |
1(0,0,0,1) | Details |
| 8442754 | Cronholm T: metabolism in isolated hepatocytes. Biochem Pharmacol. 1993 Feb 9;45(3):553-8. Effects of methylene blue, cyanamide and penicillamine on the redox state of the bound coenzyme and on the substrate exchange at alcohol dehydrogenase.. The results indicate that methylene blue inhibits aldehyde dehydrogenase and that accumulation of decreases the redox effects of |
1(0,0,0,1) | Details |
| 17989515 | Tambour S, Closon C, Tirelli E, Quertemont E: Effects of cyanamide and accumulation on the locomotor stimulant and sedative effects of in mice. Behav Pharmacol. 2007 Dec;18(8):777-84. It is concluded that in vivo the effects of cyanamide are predominantly due to the inhibition of the enzyme aldehyde dehydrogenase, rather than to its effects on catalase. |
112(1,2,2,2) | Details |
| 6640426 | Loomis CW, Brien JF: Inhibition of hepatic aldehyde dehydrogenases in the rat by carbimide cyanamide). Can J Physiol Pharmacol. 1983 Sep;61(9):1025-34. Oral administration of 7.0 mg/kg carbimide cyanamide, CC) to the rat produced differential inhibition of hepatic aldehyde dehydrogenase (ALDH) isozymes, as indicated by the time-course profiles of enzyme activity. |
112(1,2,2,2) | Details |
| 2820422 | Kohn FR, Sladek NE: Effects of aldehyde dehydrogenase inhibitors on the ex vivo sensitivity of murine late spleen colony-forming cells (day-12 CFU-S) and hematopoietic repopulating cells to mafosfamide (ASTA Z 7557). Biochem Pharmacol. 1987 Sep 1;36(17):2805-11. In the first part of the investigation, the ex vivo sensitivity of murine day-12 spleen colony-forming cells (CFU-S) to mafosfamide was determined in the absence and presence of known inhibitors of aldehyde dehydrogenase activity, viz. diethyldithiocarbamate and cyanamide. |
35(0,1,1,5) | Details |
| 3034402 | Kohn FR, Landkamer GJ, Manthey CL, Ramsay NK, Sladek NE: Effect of aldehyde dehydrogenase inhibitors on the ex vivo sensitivity of human multipotent and committed hematopoietic progenitor cells and malignant blood cells to oxazaphosphorines. Cancer Res. 1987 Jun 15;47(12):3180-5. The ex vivo sensitivity of human multipotent and committed hematopoietic progenitor cells and several cultured human malignant blood cell lines to analogues of "activated" cyclophosphamide, namely, 4-hydroperoxycyclophosphamide and mafosfamide, and to phosphoramide mustard was quantified with and without concurrent exposure to an inhibitor of aldehyde dehydrogenase activity, namely, disulfiram, cyanamide, diethyldithiocarbamate, or ethylphenyl (2-formylethyl) |
35(0,1,1,5) | Details |
| 7662040 | Marway JS, Preedy VR: The acute effects of and on the synthesis of mixed and contractile proteins of the jejunum. Alcohol Alcohol. 1995 Mar;30(2):211-7. An investigation was made into the acute effects of and with or without enzyme inhibitors of alcohol dehydrogenase (4-methylpyrazole) and aldehyde dehydrogenase (cyanamide) on fractional rates of protein synthesis of mixed and contractile proteins of the jejunum. |
31(0,1,1,1) | Details |
| 8516364 | Myers RD, Lankford MF: Failure of the 5-HT2 receptor antagonist, ritanserin, to alter preference for in drinking rats. Pharmacol Biochem Behav. 1993 May;45(1):233-7. Following the repeated administration of the inhibitor of aldehyde dehydrogenase, cyanamide, the preference for vs. water was determined in each of 20 Sprague-Dawley rats by a standard test using 3-30% concentrations. |
31(0,1,1,1) | Details |
| 8279685 | Sanny CG, Rymas K: In vivo effects of disulfiram and cyanamide on canine liver aldehyde dehydrogenase isoenzymes as detected by high-performance (pressure) liquid chromatography. Alcohol Clin Exp Res. 1993 Oct;17(5):982-7. |
12(0,0,2,2) | Details |
| 13861343 | ANDO H, FUWA I: Effects of cyanamide on alcohol dehydrogenase and aldehyde dehydrogenase. J Chromatogr. 1961 Nov;50:416-8. |
6(0,0,1,1) | Details |
| 6486817 | Dicker E, Cederbaum AI: Inhibition of the oxidation of and by hepatocytes and mitochondria by crotonaldehyde. Arch Biochem Biophys. 1984 Oct;234(1):187-96. In hepatocytes, crotonaldehyde produced about 30 to 40% inhibition of oxidation, which was similar to the inhibition produced by cyanamide. Although a poor substrate for oxidation, crotonaldehyde is an effective inhibitor of the oxidation of by mitochondrial aldehyde dehydrogenase, by intact mitochondria, and by isolated hepatocytes. |
4(0,0,0,4) | Details |
| 2807159 | Lin RC, Lumeng L: Further studies on the 37 kD liver protein- adduct that forms in vivo during chronic ingestion. Hepatology. 1989 Nov;10(5):807-14. When immunoblotted with anti-alcohol dehydrogenase and anti-aldehyde dehydrogenase antibodies, the alcohol dehydrogenase and aldehyde dehydrogenase bands in liver of -fed rats showed identical intensities before and after immunosorption.(ABSTRACT TRUNCATED AT 250 WORDS) Addition of cyanamide, an aldehyde dehydrogenase inhibitor, to the AIN'76 diet greatly increased the intensity of the 37-kD protein- adduct band on electroimmunotransblot but did not produce other bands. |
1(0,0,0,1) | Details |
| 1889554 | Preedy VR, Edwards P, Peters TJ: -induced reductions in skeletal muscle protein synthesis: use of the inhibitors of and aldehyde dehydrogenase. Biochem Soc Trans. 1991 Apr;19(2):167S. |
1(0,0,0,1) | Details |
| 4089878 | Cederbaum AI, Dicker E: Inhibition of the peroxidatic activity of catalase towards by the aldehyde dehydrogenase inhibitor cyanamide. Toxicol Lett. 1985 Dec;29(2-3):107-14. Recent results have suggested that catalase is responsible for activating cyanamide to a metabolite which is a potent inhibitor of aldehyde dehydrogenase. |
112(1,2,2,2) | Details |
| 2848231 | Helander A, Tottmar O: Effects of disulfiram, cyanamide and 1-aminocyclopropanol on the aldehyde dehydrogenase activity in human erythrocytes and leukocytes. Pharmacol Toxicol. 1988 Oct;63(4):262-5. The effects of the aldehyde dehydrogenase (ALDH; EC 1.2.1.3) inhibitors disulfiram, cyanamide and 1-aminocyclopropanol (ACP) on the ALDH activities in human erythrocytes and leukocytes were studied. |
87(1,1,2,2) | Details |
| 3827870 | Dicker E, Cederbaum AI: Inhibition of the low-Km mitochondrial aldehyde dehydrogenase by diethyl and phorone in vivo and in vitro. Biochem J. 1986 Dec 15;240(3):821-7. This increase in product formation at higher concentrations was much more sensitive to inhibition by diethyl or cyanamide, suggesting an important contribution by mitochondrial aldehyde dehydrogenase. |
35(0,1,1,5) | Details |
| 3437102 | Kohn FR, Landkamer GJ, Sladek NE: Effect of the aldehyde dehydrogenase inhibitor, cyanamide, on the ex vivo sensitivity of murine multipotent and committed hematopoietic progenitor cells to mafosfamide (ASTA Z 7557). Immunopharmacol Immunotoxicol. 1987;9(2-3):163-76. |
34(0,1,1,4) | Details |
| 8394073 | Mattia CJ, Adams JD Jr, Bondy SC: Free radical induction in the brain and liver by products of toluene catabolism. Biochem Pharmacol. 1993 Jul 6;46(1):103-10. Pretreatment of rats in vivo with 4-methylpyrazole, an alcohol dehydrogenase inhibitor, or cyanamide, an aldehyde dehydrogenase inhibitor, prior to exposure to toluene, caused a significant decrease and increase, respectively, in toluene-stimulated rates of ROS generation in the CNS and liver. |
33(0,1,1,3) | Details |
| 6353979 | Kupari M, Lindros K, Hillbom M, Heikkila J, Ylikahri R: Cardiovascular effects of accumulation after ingestion: their modification by beta-adrenergic blockade and alcohol dehydrogenase inhibition. Alcohol Clin Exp Res. 1983 Summer;7(3):283-8. Left ventricular function was examined by echocardiography and systolic time intervals in nine healthy male volunteers, who ingested 0.35 g/kg 4 hr after a 50-mg peroral dose of cyanamide, an aldehyde dehydrogenase inhibitor. |
31(0,1,1,1) | Details |
| 8397523 | Aragon CM, Spivak K, Smith BR, Amit Z: Cyanamide on intake: how does it really work? . Alcohol Alcohol. 1993 Jul;28(4):413-21. Cyanamide, an aldehyde dehydrogenase inhibitor, has been shown to suppress voluntary consumption in animals. |
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| 12036955 | You M, Fischer M, Deeg MA, Crabb DW: induces fatty acid synthesis pathways by activation of sterol regulatory element-binding protein (SREBP). J Biol Chem. 2002 Aug 9;277(32):29342-7. Epub 2002 May 29. Furthermore, the aldehyde dehydrogenase inhibitor cyanamide enhanced the effect of in the hepatoma cells. |
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| 14615007 | Moncada C, Fuentes N, Lladser A, Encina G, Sapag A, Karahanian E, Israel Y: Use of an clamp" in the determination of low-KM aldehyde dehydrogenase activity in H4-II-E-C3 rat hepatoma cells. Alcohol. 2003 Aug-Oct;31(1-2):19-24. We showed that (1) production is linear for 120 min, (2) addition of 160 microM cyanamide to the culture medium leads to a 75%-80% reduction of generated, and (3) ALDH2 activity is dependent on cell-to-cell contact and increases after cells reach confluence. |
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| 9010546 | Nosova T, Jokelainen K, Kaihovaara P, Jousimies-Somer H, Siitonen A, Heine R, Salaspuro M: Aldehyde dehydrogenase activity and production by aerobic bacteria representing the normal flora of human large intestine. Alcohol Alcohol. 1996 Nov;31(6):555-64. In addition, aerobic bacteria metabolized effectively in vitro and this could be inhibited by cyanamide in nearly half of the tested strains. |
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| 2502790 | Minano FJ, Myers RD: Inhibition of brain dopa-decarboxylase by RO 4-4602 infused ICV blocks drinking induced in rats by cyanamide. Psychopharmacology. 1989;98(2):176-82. Alternatively, benserazide could act by its central inhibition of aldehyde dehydrogenase, which in turn would concomitantly elevate levels of and thereby reduce drinking. |
1(0,0,0,1) | Details |
| 12269395 | Imamura Y, Wu X, Noda A, Noda H: Side-chain metabolism of involvement of monoamine oxidase and mitochondrial aldehyde dehydrogenase in the metabolism of N-desisopropylpropranolol to naphthoxylactic acid in rat liver. Life Sci. 2002 Apr 19;70(22):2687-97. |
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| 15858460 | : Update: cyanamide-related illnesses--Italy, 2002-2004. MMWR Morb Mortal Wkly Rep. 2005 Apr 29;54(16):405-8. The substance also inhibits aldehyde dehydrogenase and can produce syndrome (e.g., vomiting, parasympathetic hyperactivity, dyspnea, hypotension, and confusion) when exposure coincides with use. |
1(0,0,0,1) | Details |
| 15069620 | Nakamura Y, Yokoyama H, Higuchi S, Hara S, Kato S, Ishii H: accumulation suppresses Kupffer cell release of TNF-Alpha and modifies acute hepatic inflammation in rats. J Gastroenterol. 2004;39(2):140-7. BACKGROUND: -related diseases have multiple and varied associations with a highly toxic product of oxidation that accumulates in the absence of active aldehyde dehydrogenase (ALDH). Similarly, isolated rat Kupffer cells were pretreated with disulfiram or cyanamide incubated in (1 h), then challenged with LPS and evaluated 2 h later for TNF-Alpha and levels in the culture medium. |
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| 3978623 | Sladek NE, Landkamer GJ: Restoration of sensitivity to oxazaphosphorines by inhibitors of aldehyde dehydrogenase activity in cultured oxazaphosphorine-resistant L1210 and cross-linking agent-resistant P388 cell lines. Cancer Res. 1985 Apr;45(4):1549-55. The sensitivity of cultured L1210 and P388 cells sensitive (L1210/0, P388/0) and resistant (L1210/OAP, P388/CLA) to oxazaphosphorines, to 4-hydroperoxycyclophosphamide, ASTA Z-7557, phosphoramide mustard, and acrolein was determined in the absence and presence of known (disulfiram, diethyldithiocarbamate, cyanamide) or suspected [ethylphenyl (2-formylethyl) inhibitors of aldehyde dehydrogenase activity. |
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| 6733600 | Loomis CW, Brien JF: Decrease in carbimide cyanamide)-induced inhibition of rat hepatic aldehyde dehydrogenases by multiple administration. Can J Physiol Pharmacol. 1984 May;62(5):544-50. |
84(1,1,1,4) | Details |
| 3612528 | Ghanayem BI, Burka LT, Matthews HB: Metabolic basis of ethylene glycol monobutyl ether (2-butoxyethanol) toxicity: role of and aldehyde dehydrogenases. J Pharmacol Exp Ther. 1987 Jul;242(1):222-31. Pretreatment of rats with cyanamide (aldehyde dehydrogenase inhibitor) also significantly protected rats against BE-induced hematotoxicity and modified BE metabolism in a manner similar to that caused by pyrazole. |
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| 7232463 | Sinclair JD, Lindros KO: Suppression of drinking with brain aldehyde dehydrogenase inhibition. Pharmacol Biochem Behav. 1981 Mar;14(3):377-83. cyanamide, an aldehyde dehydrogenase (ALDH) inhibitor used in the treatment of alcoholism, strongly suppressed voluntary drinking by rats. |
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| 12935558 | Jamal M, Ameno K, Ameno S, Okada N, Ijiri I: Effect of different doses of cyanamide on striatal formation after treatment. Leg Med. 2003 Mar;5 Suppl 1:S79-82. To assess the dose-dependent effect of cyanamide (CY, a potent aldehyde dehydrogenase inhibitor) on release in the striatum, rats were treated with CY (25, 50 and 100 mg/kg) plus (EtOH,1 g/kg) intraperitoneally. |
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| 6612730 | Hillbom ME, Sarviharju MS, Lindros KO: Potentiation of toxicity by cyanamide in relation to accumulation. Toxicol Appl Pharmacol. 1983 Aug;70(1):133-9. The possibility that accumulation potentiates the acute toxicity of was studied by pretreating rats with cyanamide, an aldehyde dehydrogenase inhibitor. |
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| 8365577 | Smialowicz RJ, Riddle MM, Williams WC: Methoxyacetaldehyde, an intermediate metabolite of 2-methoxyethanol, is immunosuppressive in the rat. Fundam Appl Toxicol. 1993 Jul;21(1):1-7. Rats pretreated with the aldehyde dehydrogenase inhibitors disulfiram (2 mmol/kg) or cyanamide (0.48 mmol/kg) followed by oral dosing with ME (2.64 mmol/kg) resulted in suppressed PFC responses equivalent to the suppressed responses of rats dosed with ME alone. |
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| 7840616 | Hartley DP, Ruth JA, Petersen DR: The hepatocellular metabolism of by alcohol dehydrogenase, aldehyde dehydrogenase, and glutathione S-transferase. Arch Biochem Biophys. 1995 Jan 10;316(1):197-205. The presence of 4-methylpyrazole or cyanamide abolished formation of the reductive metabolite 1,4-dihydroxy-2-nonene or the oxidative metabolite 4--2-nonenoic acid in hepatocyte suspensions. |
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| 19576883 | Zhang XJ, Chang L, Zhang YM, Deng S, Li YJ, Peng J: Comparing the role of glutathione-S-transferase and mitochondrial aldehyde dehydrogenase in nitroglycerin biotransformation and the correlation with calcitonin gene-related peptide. Eur J Pharmacol. 2009 Sep 1;617(1-3):97-101. Epub 2009 Jul 2. The inhibitor of GST (ethacrynic acid) or ALDH-2 (cyanamide) was given before nitroglycerin treatment; In vitro, the isolated aorta rings were incubated with nitroglycerin to obtain the concentration-response curve. |
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| 17585900 | Chen YR, Nie SD, Shan W, Jiang DJ, Shi RZ, Zhou Z, Guo R, Zhang Z, Li YJ: Decrease in endogenous CGRP release in nitroglycerin tolerance: role of ALDH-2. Eur J Pharmacol. 2007 Sep 24;571(1):44-50. Epub 2007 Jun 5. In the present study, we tested whether the decreased release of calcitonin gene-related peptide (CGRP) observed in nitroglycerin tolerance is associated with the decrease in aldehyde dehydrogenase (ALDH-2) activity. |
1(0,0,0,1) | Details |
| 2996550 | Kohn FR, Sladek NE: Aldehyde dehydrogenase activity as the basis for the relative insensitivity of murine pluripotent hematopoietic stem cells to oxazaphosphorines. Biochem Pharmacol. 1985 Oct 1;34(19):3465-71. The ex vivo sensitivity of murine pluripotent hematopoietic stem cells (CFU-S) and myeloid progenitor cells (CFU-GM) to 4-hydroperoxycyclophosphamide, ASTA Z 7557, phosphoramide mustard, acrolein, melphalan, and cis-platinum was determined in the absence and presence of known (disulfiram, diethyldithiocarbamate, cyanamide) or suspected [ethylphenyl (2-formylethyl) inhibitors of aldehyde dehydrogenase activity. |
84(1,1,1,4) | Details |
| 17599801 | Amunom I, Stephens LJ, Tamasi V, Cai J, Pierce WM Jr, Conklin DJ, Bhatnagar A, Srivastava S, Martin MV, Guengerich FP, Prough RA: Cytochromes P450 catalyze oxidation of alpha,beta-unsaturated aldehydes. Arch Biochem Biophys. 2007 Aug 15;464(2):187-96. Epub 2007 Jun 8. Inhibitors of aldehyde dehydrogenase (cyanamide) inhibited HNA formation by 60% and together cyanamide and miconazole (P450) caused over 85% inhibition of HNA formation. |
82(1,1,1,2) | Details |
| 20029546 | Golwala NH, Hodenette C, Murthy SN, Nossaman BD, Kadowitz PJ: Vascular responses to are mediated by xanthine oxidoreductase and mitochondrial aldehyde dehydrogenase in the rat. Can J Physiol Pharmacol. 2009 Dec;87(12):1095-101. In the present study, the effects of the xanthine oxidoreductase inhibitor allopurinol and the mitochondrial aldehyde dehydrogenase inhibitor cyanamide on decreases in mean systemic arterial pressure in response to i.v. administration were investigated in the rat. |
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| 3593530 | Kitson TM: The effect of cephalosporin antibiotics on metabolism: a review. Alcohol. 1987 May-Jun;4(3):143-8. The first of these is a potent inactivator of cytoplasmic aldehyde dehydrogenase only, the second affects both cytoplasmic and mitochondrial isoenzymes. 1-Methyltetrazole-5-thiol or derivatives have the potential to be used therapeutically as 'anti- compounds in the same way as disulfiram (Antabuse) or cyanamide. |
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| 3590232 | Shirota FN, DeMaster EG, Nagasawa HT: is a product of the catalase-mediated oxidation of the deterrent agent, cyanamide. Toxicol Lett. 1987 Jun;37(1):7-12. was detected as a product of cyanamide oxidation by bovine liver catalase in vitro under conditions that also produced an active aldehyde dehydrogenase (AlDH) inhibitor. |
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| 2886987 | Penttila KE, Makinen J, Lindros KO: Allyl liver injury: suppression by and relation to transient depletion. Pharmacol Toxicol. 1987 May;60(5):340-4. On the other hand, attempts to potentiate the toxicity of acrolein by the aldehyde dehydrogenase inhibitor cyanamide enhanced only the release of alanine aminotransferase. |
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| 3067622 | Cao QN, Tu GC, Weiner H: Mitochondria as the primary site of metabolism in beef and pig liver slices. Alcohol Clin Exp Res. 1988 Oct;12(5):720-4. Aldehyde dehydrogenase (ALDH) is the major enzyme involved in the oxidation of Using slices isolated from beef and pig livers and selectively inhibiting the mitochondria enzyme with cyanamide or the cytosolic enzyme with disulfiram, it was possible to address this question. |
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| 7115421 | Shirota FN, DeMaster EG, Nagasawa HT: Studies on the cyanamide- interaction. Biochem Pharmacol. 1982 Jun 1;31(11):1999-2004. Dimethylcyanamide as an inhibitor of aldehyde dehydrogenase in vivo.. |
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| 6761704 | Petersen DR, Hjelle JJ: Metabolic interactions of aldehyde dehydrogenase with therapeutic and toxic agents. Prog Clin Biol Res. 1982;114:103-20. |
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| 9632053 | Nosova T, Jokelainen K, Kaihovaara P, Heine R, Jousimies-Somer H, Salaspuro M: Characteristics of aldehyde dehydrogenases of certain aerobic bacteria representing human colonic flora. Alcohol Alcohol. 1998 May-Jun;33(3):273-80. The effect of cyanamide, a potent inhibitor of mammalian ALDH, on bacterial ALDH activity was also studied. |
2(0,0,0,2) | Details |
| 3889625 | Neudecker T, Henschler D: is mutagenic in Salmonella typhimurium. Mutat Res. 1985 Apr-May;156(1-2):33-7. Another metabolic pathway, namely hydrolysis to allyl and oxidation to acrolein, a known mutagen, also seems possible as cyanamide, inhibitor of aldehyde dehydrogenase, can slightly increase the mutagenic potential. Another metabolic pathway, namely hydrolysis to allyl and oxidation to acrolein, a known mutagen, also seems possible as cyanamide, inhibitor of aldehyde dehydrogenase, can slightly increase the mutagenic potential. |
1(0,0,0,1) | Details |
| 10528996 | Hammond AH, Fry JR: Effect of cyanamide on toxicity and depletion in rat hepatocyte cultures: differences between two dichloropropanol isomers. Chem Biol Interact. 1999 Sep 30;122(2):107-15. The effect of aldehyde dehydrogenase inhibition by cyanamide pre-treatment in vitro on dichloropropanol-dependent toxicity and depletion was investigated in 24 h rat hepatocyte cultures. |
82(1,1,1,2) | Details |
| 7013545 | Cederbaum AI: The effect of cyanamide on oxidation by isolated rat liver mitochondria and on the inhibition of oxidation by Alcohol Clin Exp Res. 1981 Jan;5(1):38-44. Cyanamide also inhibited the activity of aldehyde dehydrogenase assayed in disrupted mitochondrial fractions. |
82(1,1,1,2) | Details |
| 9667978 | Conway TT, DeMaster EG, Lee MJ, Nagasawa HT: Prodrugs of and nitrosobenzene as cascade latentiated inhibitors of aldehyde dehydrogenase. J Med Chem. 1998 Jul 16;41(15):2903-9. The prototypic aromatic C-nitroso compound, nitrosobenzene (NB), was shown previously to mimic the effect of (HN=O), the putative active metabolite of cyanamide, in inhibiting aldehyde dehydrogenase (AlDH). |
82(1,1,1,2) | Details |
| 8512594 | Nagasawa HT, Yost Y, Elberling JA, Shirota FN, DeMaster EG: analogs as inhibitors of aldehyde dehydrogenase. Biochem Pharmacol. 1993 May 25;45(10):2129-34. We previously postulated that the catalase-mediated oxidation of cyanamide leads to the formation of the unstable intermediate, N-hydroxycyanamide, which spontaneously decomposes to the putative inhibitor of aldehyde dehydrogenase (EC 1.2.1.3; AlDH). |
32(0,1,1,2) | Details |
| 3324799 | Spivak K, Aragon CM, Amit Z: Alterations in brain aldehyde dehydrogenase activity modify -induced conditioned taste aversion. Alcohol Clin Exp Res. 1987 Dec;11(6):513-7. Cyanamide, an aldehyde dehydrogenase inhibitor (ALDH) elevates blood levels in the presence of |
32(0,1,1,2) | Details |
| 1471767 | Lin RC, Sidner RA, Fillenwarth MJ, Lumeng L: Localization of protein- adducts on cell surface of hepatocytes by flow cytometry. Alcohol Clin Exp Res. 1992 Dec;16(6):1125-9. In another experiment, hepatocytes were isolated from rats pair-fed cyanamide (a selective aldehyde dehydrogenase inhibitor) with and without |
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| 16131499 | Patel VB, Worrall S, Emery PW, Preedy VR: Protein adduct species in muscle and liver of rats following acute administration. Alcohol Alcohol. 2005 Nov-Dec;40(6):485-93. Epub 2005 Aug 30. These were used to assay different adduct species in soleus (type I fibre-predominant) and plantaris (type II fibre-predominant) muscles and liver in four groups of rats administered acutely with either [A] saline (control); [B] cyanamide (an aldehyde dehydrogenase inhibitor); [C] [D] cyanamide+ethanol. |
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| 8353517 | Leal JF, Barbancho M: Aldehyde dehydrogenase (ALDH) activity in Drosophila melanogaster adults: evidence for cytosolic localization. Insect Biochem Mol Biol. 1993 Jul;23(5):543-7. ALDH activities from ALDH or ADH (EC 1.1.1.1) enzymes were selectively inhibited by prefeeding respectively the flies solutions supplemented with either cyanamide or respectively. |
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| 10190574 | de Zwart LL, Vermeulen NP, Hermanns RC, Commandeur JN, Salemink PJ, Meerman JH: Urinary excretion of biomarkers for radical-induced damage in rats treated with NDMA or diquat and the effects of carbimide co-administration. Chem Biol Interact. 1999 Jan 29;117(2):151-72. Furthermore, the effect of co-administration of the aldehyde dehydrogenase inhibitor, carbimide (CC) on the urinary excretion of the aldehydes was determined. |
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| 2499314 | Heinstra PW, Geer BW, Seykens D, Langevin M: The metabolism of -derived by alcohol dehydrogenase (EC 1.1.1.1) and aldehyde dehydrogenase (EC 1.2.1.3) in Drosophila melanogaster larvae. Biochem J. 1989 May 1;259(3):791-7. The enzymes, however, showed different inhibition patterns with respect to pyrazole, cyanamide and disulphiram. |
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| 2573707 | Obach R, Colom H, Arso J, Peraire C, Prunonosa J: Pharmacokinetics of cyanamide in dog and rat. J Pharm Pharmacol. 1989 Sep;41(9):624-7. A pharmacokinetic study of cyanamide, an inhibitor of aldehyde dehydrogenase (E.C. 1.2.1.3) has been made in the beagle dog and Sprague-Dawley rat. |
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| 19657887 | de Haro L: Disulfiram-like syndrome after cyanamide professional skin exposure: two case reports in France. J Agromedicine. 2009;14(3):382-4. Contact with the skin can result in percutaneous absorption of the substance that inhibits aldehyde dehydrogenase and can induce syndrome in case of use. |
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| 15289380 | Zhang J, Chen Z, Cobb FR, Stamler JS: Role of mitochondrial aldehyde dehydrogenase in nitroglycerin-induced vasodilation of coronary and systemic vessels: an intact canine model. Circulation. 2004 Aug 10;110(6):750-5. Epub 2004 Aug 2. Each dog was given a 1-mL bolus injection of GTN, sodium nitroprusside (SNP), or through a catheter in the left atrium before and 30 minutes after infusion of cyanamide (17 mg/kg), an inhibitor of mtALDH. |
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| 9972923 | Lee JY, Chung SM, Lee MY, Chung JH: co-exposure increases lethality of allyl in male Sprague-Dawley rats. J Toxicol Environ Health A. 1999 Jan 22;56(2):121-30. Since allyl and are both metabolized by alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), could affect allyl- induced toxicity under in vivo coexposure conditions. |
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| 11498807 | Stanek J, Symanowicz PT, Olsen JE, Gianutsos G, Morris JB: Sensory-nerve-mediated nasal vasodilatory response to inspired and vapors. Inhal Toxicol. 2001 Sep;13(9):807-22. is metabolized by aldehyde dehydrogenase to Pretreatment with the aldehyde dehydrogenase inhibitor cyanamide (10 mg/kg, 1 h prior to exposure) reduced the vasodilatory response to 200 ppm but not to 50 ppm |
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| 10791063 | Pron'ko PS, Kuz'mich AB, Abakumov GZ: [Effect of alcohol intoxication and aldehyde dehydrogenase inhibitors on lipid peroxidation in rat liver]. Ukr Biokhim Zh. 1999 Jul-Aug;71(4):79-83. Cyanamide (50 mg/kg, 2 h before the increased approximately 100-fold the levels, however, the changes in lipid peroxidation were not significantly different from that produced by alone. |
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| 8843167 | Svensson S, Lundsjo A, Cronholm T, Hoog JO: dismutase activity of human liver alcohol dehydrogenase. . FEBS Lett. 1996 Sep 30;394(2):217-20. The class I beta1beta1 isozyme and the class II alcohol dehydrogenase showed moderate catalytic efficiencies for dismutase activity with lower kcat values, 60-75 min (-1). 4-Methylpyrazole, a potent class I ADH inhibitor, inhibited the class I dismutation completely, but cyanamide, an inhibitor of mitochondrial aldehyde dehydrogenase, did not affect the dismutation. The dismutase reaction might be important for metabolism of aldehydes during inhibition or lack of mitochondrial aldehyde dehydrogenase activity. |
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| 2329500 | Ghanayem BI, Sanders JM, Clark AM, Bailer J, Matthews HB: Effects of dose, age, inhibition of metabolism and elimination on the toxicokinetics of 2-butoxyethanol and its metabolites. J Pharmacol Exp Ther. 1990 Apr;253(1):136-43. Recently, we have shown that butoxyacetic acid (BAA) is the proximate hemolytic agent and that inhibition of or aldehyde dehydrogenases protected rats against BE-induced hemolytic anemia. In the present investigations, the kinetics of 14C-BE metabolism and clearance were studied in control adult (3-4 months old) and old (12-13 months old) male F344 rats and in adult male F344 rats treated with pyrazole, cyanamide or probenecid. |
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| 1448464 | Myers RD, Lankford M, Bjork A: Selective reduction by the antagonist amperozide of preference induced in rats by systemic cyanamide. Pharmacol Biochem Behav. 1992 Nov;43(3):661-7. This investigation was undertaken to determine the effect of a unique psychotropic agent on the volitional drinking of induced pharmacologically in the rat by an inhibitor of aldehyde dehydrogenase. |
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| 1766365 | Heinstra PW, Geer BW: Metabolic control analysis and enzyme variation: nutritional manipulation of the flux from to lipids in Drosophila. Mol Biol Evol. 1991 Sep;8(5):703-8. The effect that variation in activities of the enzymes alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) has on the flux from 14C- to lipids was examined in third-instar larvae of Drosophila melanogaster and D. simulans. The activities of ADH and ALDH were also nutritionally manipulated by the inhibitor, cyanamide. |
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| 2312053 | Lin RC, Fillenwarth MJ, Minter R, Lumeng L: Formation of the 37-kD protein- adduct in primary cultured rat hepatocytes exposed to Hepatology. 1990 Mar;11(3):401-7. Although the maximal intensity was obtained at approximately 10 to 40 mmol/L addition of cyanamide (an inhibitor of aldehyde dehydrogenase) further increased the intensity of this protein- adduct band by more than twofold. Although the maximal intensity was obtained at approximately 10 to 40 mmol/L addition of cyanamide (an inhibitor of aldehyde dehydrogenase) further increased the intensity of this protein- adduct band by more than twofold. |
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| 7923171 | Andersson BS, Mroue M, Britten RA, Murray D: The role of DNA damage in the resistance of human chronic myeloid leukemia cells to cyclophosphamide analogues. Cancer Res. 1994 Oct 15;54(20):5394-400. To determine whether the approximately 9-fold reduction of initial 4HC-induced ISCs was related to elevated aldehyde dehydrogenase (ADH), we examined PM-mediated cytotoxicity and ISC induction in the two cell lines. Furthermore, when cells were exposed to 4HC in the presence of 40 micrograms/ml cyanamide, an efficient inhibitor of ADH, the resistance index based on the 50% inhibitory concentration values was decreased to approximately 8. |
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| 3724077 | Jones AW: Drug-alcohol flush reaction and breath concentration: no interference with an infrared breath analyzer. J Anal Toxicol. 1986 May-Jun;10(3):98-101. carbimide, an inhibitor of aldehyde dehydrogenase, caused intense facial flushing and a pronounced rise in the concentration of in breath. |
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| 3759956 | Kosugi K, Chandramouli V, Kumaran K, Schumann WC, Landau BR: Determinants in the pathways followed by the carbons of in their conversion to J Biol Chem. 1986 Oct 5;261(28):13179-81. When rats were given cyanamide and then the large dose of 74% of the 14C in the they formed was in carbons 3 and 4 of the glucoses. Thus, the relative contribution of the pathway to lactate, or its metabolic equivalent, that has been proposed appears to be lessened by the administration of an aldehyde dehydrogenase inhibitor. |
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| 4015825 | Svanas GW, Weiner H: Use of cyanamide to determine localization of metabolism in rat liver. Alcohol. 1985 Jan-Feb;2(1):111-5. Mitochondrial low-Km aldehyde dehydrogenase (ALDH) was partially inactivated and the effect on oxidation measured. |
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| 17047928 | Izco M, Orio L, O'Shea E, Colado MI: Binge administration enhances the MDMA-induced long-term neurotoxicity in rat brain. Psychopharmacology. 2007 Jan;189(4):459-70. Epub 2006 Oct 18. The magnitude of this effect is more pronounced after increasing plasma levels by aldehyde dehydrogenase inhibition. A group of rats received cyanamide (50 mg/kg) on days 1 and 3 of the 4-day- inhalation. |
1(0,0,0,1) | Details |
| 12711651 | Jamal M, Ameno K, Kubota T, Ameno S, Zhang X, Kumihashi M, Ijiri I: In vivo formation of induced by high concentration in rat striatum employing microdialysis. Alcohol Alcohol. 2003 May-Jun;38(3):197-201. AIMS: The in vivo formation of (1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquionoline), an endogeneous condensation product of (DA) with (AcH), was examined following the administration of cyanamide (CY) plus (EtOH) using microdialysis-high-performance liquid chromatography with electrochemical detection. METHODS: After the insertion of a microdialysis probe into the striatum, rats were treated with CY (a potent inhibitor of aldehyde dehydrogenase, 50 mg/kg), 4-methylpyrazole (4-MP, a strong inhibitor of alcohol dehydrogenase, 82 mg/kg), and CY + 4-MP, followed 1 h later by EtOH (1 g/kg), CY and 4-MP only by intraperitoneal administration. |
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| 9794917 | Bailey SM, Cunningham CC: Acute and chronic increases reactive species generation and decreases viability in fresh, isolated rat hepatocytes. Hepatology. 1998 Nov;28(5):1318-26. Incubation with an -oxidizing compound, and cyanamide, an inhibitor of aldehyde dehydrogenase, significantly decreased ROS levels in acute -treated hepatocytes. Incubation with an -oxidizing compound, and cyanamide, an inhibitor of aldehyde dehydrogenase, significantly decreased ROS levels in acute -treated hepatocytes. |
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| 3178876 | Kera Y, Ohbora Y, Komura S: The metabolism of and not itself is responsible for in vivo -induced lipid peroxidation in rats. Biochem Pharmacol. 1988 Oct 1;37(19):3633-8. The cyanamide treatment (15 mg/kg) effectively decreased 83% of the low Km and 70% of the high Km ALDH in the liver. |
0(0,0,0,0) | Details |
| 6298405 | Zaleska MM, Gessner PK: Metabolism of [14C] paraldehyde in mice in vivo, generation and trapping of J Pharmacol Exp Ther. 1983 Mar;224(3):614-9. Pretreatment with the aldehyde dehydrogenase inhibitors, pargyline or cyanamide, did not result in the accumulation or excretion of detectable amounts of AcH. |
0(0,0,0,0) | Details |
| 3287984 | Speisky H, Kera Y, Penttila KE, Israel Y, Lindros KO: Depletion of hepatic by occurs independently of metabolism. Alcohol Clin Exp Res. 1988 Apr;12(2):224-8. Neither inhibition of metabolism with 4-methylpyrazole, nor a 10-fold elevation of levels by inhibition of aldehyde dehydrogenase with cyanamide or disulfiram, affected the magnitude of the GSH depletion observed in vivo. |
0(0,0,0,0) | Details |
| 11893554 | Duan J, McFadden GE, Borgerding AJ, Norby FL, Ren BH, Ye G, Epstein PN, Ren J: Overexpression of alcohol dehydrogenase exacerbates -induced contractile defect in cardiac myocytes. Am J Physiol Heart Circ Physiol. 2002 Apr;282(4):H1216-22. Pretreatment with the ADH inhibitor 4-methylpyrazole (4-MP) or the aldehyde dehydrogenase inhibitor cyanamide prevented or augmented the -induced inhibition, respectively, in the ADH but not the FVB group. |
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| 9556565 | Srivastava S, Chandra A, Wang LF, Seifert WE Jr, DaGue BB, Ansari NH, Srivastava SK, Bhatnagar A: Metabolism of the lipid peroxidation product, 4--trans-2-nonenal, in isolated perfused rat heart. J Biol Chem. 1998 May 1;273(18):10893-900. When exposed to sorbinil, an inhibitor of aldose reductase, no GS-DHN was recovered in the coronary effluent, and treatment with cyanamide, an inhibitor of aldehyde dehydrogenase, attenuated 4-hydroxy-2-nonenoic acid formation. |
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| 8707122 | Altomare E, Grattagliano I, Vendemiale G, Palmieri V, Palasciano G: Acute administration induces oxidative changes in rat pancreatic tissue. Gut. 1996 May;38(5):742-6. Pretreatment with cyanamide (an inhibitor of aldehyde dehydrogenase) but not with 4-methylpyrazole (an alcohol dehydrogenase inhibitor) caused higher production of GSSG and MDA. |
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| 8974374 | Helander A, Beck O, Borg S: The use of as an intake marker. Alcohol Alcohol Suppl. 1994;2:497-502. Disulfiram and cyanamide, however, will elevate urinary 5HTOL/5HIAA ratio. |
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| 15950440 | Tambour S, Didone V, Tirelli E, Quertemont E: Dissociation between the locomotor and anxiolytic effects of in the elevated plus-maze: evidence that is not involved in the anxiolytic effects of in mice. Eur Neuropsychopharmacol. 2005 Dec;15(6):655-62. Epub 2005 Jun 9. In an independent experiment, cyanamide, an aldehyde dehydrogenase inhibitor, prevented the locomotor stimulant effects of although it failed to alter its anxiolytic effects. |
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| 2394940 | Solomon LR, Crouch JY: delta-Aminolevulinic acid dehydratase in rat liver: studies on the effects of and B6 vitamers. J Lab Clin Med. 1990 Aug;116(2):228-36. Inactivation of ALAD by was prevented by the metabolic inhibitor NaF but not by the aldehyde dehydrogenase inhibitor cyanamide. |
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