| Name | alanine aminotransferase |
|---|---|
| Synonyms | AAT1; AAT1; GPT; ALT 1; ALT1; Alanine aminotransferase; Alanine aminotransferase 1; GPT 1… |
| Name | cyanamide |
|---|---|
| CAS | cyanamide |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 3677417 | Solomon LR: Studies on the mechanism of -mediated inhibition of rat liver transaminases. Clin Chim Acta. 1987 Sep 30;168(2):207-17. Incubation of mitochondria-depleted rat liver homogenates with 5 mmol/l at 37 degrees C for 1 h inhibited both and alanine aminotransferases by 30%. Inhibition was prevented by decreasing temperature to 4 degrees C or by preincubating homogenates with but was unaffected by cyanamide and methylpyrazole which block oxidation and reduction respectively. |
1(0,0,0,1) | Details |
| 2886987 | Penttila KE, Makinen J, Lindros KO: Allyl liver injury: suppression by and relation to transient depletion. Pharmacol Toxicol. 1987 May;60(5):340-4. On the other hand, attempts to potentiate the toxicity of acrolein by the aldehyde dehydrogenase inhibitor cyanamide enhanced only the release of alanine aminotransferase. |
32(0,1,1,2) | Details |
| 10803789 | Tamai H, Yokoyama A, Okuyama K, Takahashi H, Maruyama K, Suzuki Y, Ishii H: Comparison of cyanamide and disulfiram in effects on liver function. . Alcohol Clin Exp Res. 2000 Apr;24(4 Suppl):97S-99S. Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels obtained at 0, 4, 8, and 12 weeks of administration of each aversive drug were compared between the two alcoholic groups. |
1(0,0,0,1) | Details |
| 3508430 | Younes M, Strubelt O: -induced hepatotoxicity: a role for free radicals. Free Radic Res Commun. 1987;3(1-5):19-26. Perfusion of isolated rat livers with at a concentration of 2 g/l (%o) resulted in a release of glutamate-pyruvate-transaminase (GPT) and sorbitol dehydrogenase (SDH) into the perfusate as markers of toxicity. Inhibition of alcohol dehydrogenase by 4-methylpyrazole or of aldehyde dehydrogenase by cyanamide totally abolished hepatotoxicity despite of a severalfold increase in concentration in the perfusate. |
1(0,0,0,1) | Details |
| 3663401 | Solomon LR: Evidence for the generation of transaminase inhibitor (s) during metabolism by rat liver homogenates: a potential mechanism for toxicity. Biochem Med Metab Biol. 1987 Aug;38(1):9-18. When homogenates were incubated at 37 degrees with 50 mM for 1 hr, alanine aminotransferase decreased by 20%, while aspartate aminotransferase was unchanged. Cyanamide, an aldehyde dehydrogenase inhibitor, had little effect on -mediated transaminase inhibition. |
1(0,0,0,1) | Details |
| 2886311 | Rikans LE: The oxidation of acrolein by rat liver aldehyde dehydrogenases. Drug Metab Dispos. 1987 May-Jun;15(3):356-62. The metabolism of acrolein by low Km aldehyde dehydrogenase activities was markedly depressed in mitochondrial or cytosolic fractions from rats pretreated with cyanamide (2 mg/kg for 1 hr) or disulfiram (100 mg/kg for 24 hr). Hepatotoxicity was assessed on the basis of elevated serum alanine aminotransferase and sorbitol dehydrogenase activities and the loss of microsomal cytochrome P-450. |
1(0,0,0,1) | Details |