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Smith CM, Israel BC, Iannucci J, Marino KA: Possible role of acetyl-CoA in the inhibition of CoA biosynthesis by ethanol in rats. J Nutr. 1987 Mar;117(3):452-9.
Cyanamide and diethyldithiocarbamate decreased the inhibition by acetaldehyde at the same concentration (10 microM), which saturated their ability to inhibit acetaldehyde oxidation. Studies with an isolated pantothenate kinase preparation showed that, of the ethanol metabolites, only acetyl-CoA was an effective inhibitor. |
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