| Name | catalase |
|---|---|
| Synonyms | CAT; Catalase; Erythrocyte derived growth promoting factor; Carnitine O acetyltransferase; Carnitine acetylase; Carnitine acetyltransferase; CAT; Catalases… |
| Name | cyanamide |
|---|---|
| CAS | cyanamide |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 4040375 | DeMaster EG, Shirota FN, Nagasawa HT: Catalase mediated conversion of cyanamide to an inhibitor of aldehyde dehydrogenase. Physiol Behav. 2001 Jul;73(4):641-7. |
436(5,6,6,6) | Details |
| 3729967 | DeMaster EG, Redfern B, Shirota FN, Nagasawa HT: Differential inhibition of rat tissue catalase by cyanamide. . Toxicol Lett. 1987 Jun;37(1):7-12. |
405(5,5,5,5) | Details |
| 4089878 | Cederbaum AI, Dicker E: Inhibition of the peroxidatic activity of catalase towards by the aldehyde dehydrogenase inhibitor cyanamide. J Plant Physiol. 2005 Mar;162(3):301-8. |
355(4,5,5,5) | Details |
| 2272522 | Rikans LE, Snowden CD, Moore DR: Influence of aging on and oxidation in female rat liver. Gerontology. 1990;36(4):185-92. Rates of metabolism by alcohol dehydrogenase, the microsomal oxidizing system (MEOS), and catalase were similar in liver preparations from young (4-5 months) and old (24-27 months) female Fischer 344 rats. Results with the ALDH inhibitor cyanamide indicated that a decline in ALDH activity of this magnitude would not increase acute hepatotoxicity. |
1(0,0,0,1) | Details |
| 2505770 | DeMaster EG, Raij L, Archer SL, Weir EK: is a vasorelaxant and a possible intermediate in the oxidative conversion of to Drug Metab Dispos. 1991 Jul-Aug;19(4):787-92. Catalase, an enzyme known to oxidize to was present in homogenates of intact and endothelium-denuded rings. Cyanamide, another catalase substrate and a known precursor of (HNO), was not a vasorelaxant of aortic rings or of isolated, hypoxia-constricted lungs. |
1(0,0,0,1) | Details |
| 7847615 | Sisson JH, Tuma DJ: Vapor phase exposure to generated from inhibits bovine bronchial epithelial cell ciliary motility. Alcohol Clin Exp Res. 1994 Oct;18(5):1252-5. When cells were pretreated with cyanamide, which is known to block dehydrogenase, the time to ciliastasis was decreased by 10-30 min compared with untreated cells.(ABSTRACT TRUNCATED AT 250 WORDS) The separate dish contained or an -generating system (AGS) that consisted of + + oxidase + catalase. |
1(0,0,0,1) | Details |
| 6378202 | DeMaster EG, Shirota FN, Nagasawa HT: The metabolic activation of cyanamide to an inhibitor of aldehyde dehydrogenase is catalyzed by catalase. Biochem Biophys Res Commun. 1984 Jul 18;122(1):358-65. Although hepatic catalase was also inhibited by cyanamide, a positive correlation between blood and hepatic catalase activity was observed. |
314(3,5,6,9) | Details |
| 10379628 | Sanchis-Segura C, Miquel M, Correa M, Aragon CM: Cyanamide reduces brain catalase and -induced locomotor activity: is there a functional link?. Psychopharmacology. 1999 May;144(1):83-9. |
311(3,5,6,6) | Details |
| 3590232 | Shirota FN, DeMaster EG, Nagasawa HT: is a product of the catalase-mediated oxidation of the deterrent agent, cyanamide. Alcohol Clin Exp Res. 1991 Mar;15(2):165-9. |
250(3,3,4,5) | Details |
| 10424762 | Clement B, Boucher JL, Mansuy D, Harsdorf A: Microsomal formation of and cyanamides from non-physiological N-hydroxyguanidines: N-hydroxydebrisoquine as a model substrate. Biochem Pharmacol. 1999 Aug 1;58(3):439-45. The oxidation of N-hydroxydebrisoquine by liver microsomes from rats pretreated with dexamethasone not only produced and the urea, but also the cyanamide derivative as the main metabolite. Experiments with catalase, superoxide dismutase, and H2O2 showed that the O2- formed from the enzyme and the substrate apparently participated in the reaction. |
1(0,0,0,1) | Details |
| 18324412 | Halaly T, Pang X, Batikoff T, Crane O, Keren A, Venkateswari J, Ogrodovitch A, Sadka A, Lavee S, Or E: Similar mechanisms might be triggered by alternative external stimuli that induce dormancy release in grape buds. Neurotoxicology. 2007 Nov;28(6):1245-8. Epub 2007 May 13. We compared the effects of heat shock (HS) and cyanamide (HC) and demonstrated that HS leads to earlier and higher bud-break levels. Changes in transcript levels of catalase, alcohol dehydrogenase and decarboxylase were induced following both treatments. |
1(0,0,0,1) | Details |
| 12237745 | Mega BT, Sheppard KW, Williams HL, McMillen BA: On the role of monoamine oxidase-A for the maintenance of the volitional consumption of in two different rat models. Planta. 2008 Jun;228(1):79-88. Epub 2008 Mar 7. Specifically, peroxide may be used as a co-substrate for the metabolism of to by catalase and the action of monoamine oxidase in the monoaminergic neurons would supply the peroxide. In the cyanamide-induced drinking rat, 50 mg/kg BW A616U reduced consumption of by 37%. |
1(0,0,0,1) | Details |
| 17590992 | Jamal M, Ameno K, Ikuo U, Kumihashi M, Wang W, Ijiri I: and in vivo quantitation and effects on cholinergic function in rat brain. Novartis Found Symp. 2007;285:137-41; discussion 141-4 The study suggested that catalase made a significant contribution to formation in the rat brain, and that EtOH and decreased ChAT expression at 40 and 240 min after EtOH dosing. The results showed that was present in the cyanamide (CY) + EtOH, CY + 4-methylpyrazole (4-MP) + EtOH and CY + azide + EtOH groups. |
1(0,0,0,1) | Details |
| 2058789 | Aragon CM, Stotland LM, Amit Z: Studies on -brain catalase interaction: evidence for central oxidation. J Med Chem. 1990 Dec;33(12):3120-2. Results confirmed inhibition of brain catalase activity by cyanamide and 4-hydroxypyrazole. |
229(2,4,4,9) | Details |
| 17989515 | Tambour S, Closon C, Tirelli E, Quertemont E: Effects of cyanamide and accumulation on the locomotor stimulant and sedative effects of in mice. Behav Pharmacol. 2007 Dec;18(8):777-84. The results of such studies are, however, difficult to interpret because cyanamide is an inhibitor of the enzymes catalase and aldehyde dehydrogenase, two enzymes with opposite effects on brain concentrations. |
162(2,2,2,2) | Details |
| 1961756 | Murphy ME, Sies H: Reversible conversion of anion to by superoxide dismutase. Biochem Pharmacol. 1992 Jul 7;44(1):93-8. When cyanamide and catalase were used to generate NO- in the presence of SOD, NO was measured by the conversion of HbO2 to MetHb. |
0(0,0,0,0) | Details |
| 3342079 | DeMaster EG, Stevens JM: Acute effects of the aldehyde dehydrogenase inhibitors, disulfiram, pargyline and cyanamide, on circulating ketone body levels in the rat. Arch Int Pharmacodyn Ther. 1980 Jan;243(1):17-26. |
0(0,0,0,0) | Details |
| 3426683 | Shirota FN, DeMaster EG, Kwon CH, Nagasawa HT: Metabolism of cyanamide to and an inhibitor of aldehyde dehydrogenase (ALDH) by rat liver microsomes. Hoppe Seylers Z Physiol Chem. 1961 Sep 20;325:183-8. Rat liver microsomes, as well as purified catalase, convert the deterrent agent, cyanamide, to an active inhibitor of AlDH. |
162(2,2,2,2) | Details |
| 8135870 | Fukuto JM, Gulati P, Nagasawa HT: Involvement of (HNO) in the cyanamide-induced vasorelaxation of rabbit aorta. Alcohol. 1985 Jan-Feb;2(1):117-21. Since the oxidation of cyanamide by catalase/H2O2 had been shown previously to lead to (HNO) generation via the intermediate N-hydroxycyanamide, and aortic ring relaxation was inhibited by the catalase inhibitor, 3-aminotriazole, HNO appears to be responsible for the vasorelaxation mediated by cyanamide. |
113(1,2,2,3) | Details |
| 1680656 | Prunonosa J, Sagrista ML, Bozal J: Inactivation mechanism of low-KM rat liver mitochondrial aldehyde dehydrogenase by cyanamide in vitro. Biochem Pharmacol. 1989 Jul 1;38(13):2099-105. The effect of the concentrations of NAD+ at different concentrations of catalase on the inactivation of ALDH by cyanamide (20 and 200 microM) in vitro point to an ALDH-NAD (+)-catalase complex prior to the binding to cyanamide to form the holoenzyme-inhibitor complex. |
112(1,2,2,2) | Details |
| 2735948 | Prunonosa J, Sagrista ML, Bozal J: Inactivation of low-Km rat liver mitochondrial aldehyde dehydrogenase by cyanamide in vitro. Biochem Pharmacol. 1996 Jul 12;52(1):141-7. The inactivation of the affinity chromatography purified low-Km rat liver mitochondrial aldehyde dehydrogenase (ALDH)--free of catalase activity--by the sensitizing agent cyanamide was studied in vitro. |
100(0,3,4,5) | Details |
| 11790383 | Shahidullah M, Duncan A, Strachan PD, Rafique KM, Ball SL, McPate MJ, Nelli S, Martin W: Role of catalase in the smooth muscle relaxant actions of azide and cyanamide. Eur J Pharmacol. 2002 Jan 18;435(1):93-101. Moreover, results obtained using a difference spectrophotometric assay based upon the oxidation of haemoglobin were consistent with the catalase-dependent oxidation of azide to (NO) and of cyanamide to anion. |
93(1,1,3,3) | Details |
| 8614253 | Rotzinger S, Aragon CM, Rogan F, Amir S, Amit Z: The synthase inhibitor NW-nitro- methylester attenuates brain catalase activity in vitro. Psychopharmacology. 2003 May;167(2):130-6. Epub 2003 Mar 25. L-NAME was found to attenuate the catalase inhibiting effects of the known catalase inhibitor cyanamide in vitro, suggesting a competition between cyanamide and L-NAME for catalase. |
87(1,1,1,7) | Details |
| 2790779 | Silva JM, O'Brien PJ: Diaziquone-induced cytotoxicity in isolated rat hepatocytes. . Biochem Pharmacol. 1993 May 25;45(10):2129-34. The extent of GSH oxidation increased with AZQ concentration. (b) Cytotoxicity occurred when AZQ concentrations were sufficient to completely deplete GSH. (c) Addition of AZQ to hepatocytes enhanced -resistant respiration. (d) If the hepatocytes were compromised with azide or cyanamide to inhibit catalase, cytotoxicity was increased 10-fold or 100-fold if was also present. (e) AZQ readily induced Ca2+ release by energized mitochondria. |
82(1,1,1,2) | Details |
| 13860900 | AMBERGER A: [On the inhibition of plant catalase by cyanamide.] Life Sci. 1995 Mar 10;56(16):1321-4. |
81(1,1,1,1) | Details |
| 2258896 | Nagasawa HT, DeMaster EG, Redfern B, Shirota FN, Goon DJ: Evidence for in the catalase-mediated bioactivation of the deterrent agent cyanamide. Cancer Res. 1989 Oct 15;49(20):5550-4. |
81(1,1,1,1) | Details |
| 4015825 | Svanas GW, Weiner H: Use of cyanamide to determine localization of metabolism in rat liver. Alcohol. 1985 Jan-Feb;2(1):111-5. An enzymatic activation of cyanamide, probably by catalase, was necessary for the drug to inhibit ALDH activity. |
81(1,1,1,1) | Details |
| 8512594 | Nagasawa HT, Yost Y, Elberling JA, Shirota FN, DeMaster EG: analogs as inhibitors of aldehyde dehydrogenase. Naunyn Schmiedebergs Arch Pharmacol. 2002 Oct;366(4):319-26. Epub 2002 Aug 20. We previously postulated that the catalase-mediated oxidation of cyanamide leads to the formation of the unstable intermediate, N-hydroxycyanamide, which spontaneously decomposes to the putative inhibitor of aldehyde dehydrogenase (EC 1.2.1.3; AlDH). |
81(1,1,1,1) | Details |
| 15608607 | Pastor R, Sanchis-Segura C, Aragon CM: Brain catalase activity inhibition as well as opioid receptor antagonism increases -induced HPA axis activation. Alcohol Clin Exp Res. 2004 Dec;28(12):1898-906. In addition, we tested the effects of 45 mg/kg of cyanamide (another catalase inhibitor) and 0 to 2 mg/kg of naltrexone (nonselective opioid receptor antagonist) on -induced enhancement in plasma values. |
74(0,2,3,9) | Details |
| 3994742 | Svanas GW, Weiner H: Enzymatic requirement for cyanamide inactivation of rat liver aldehyde dehydrogenase. Biochem Pharmacol. 1985 Apr 15;34(8):1197-204. Commun., 122, 358 (1984)] that catalase is the cyanamide-converting enzyme. |
62(0,2,2,2) | Details |
| 1632841 | Aragon CM, Rogan F, Amit Z: metabolism in rat brain homogenates by a catalase-H2O2 system. Alcohol Alcohol Suppl. 1987;1:219-23. Homogenates of perfused brains of rats treated with 3-amino-1,2,4-triazole or cyanamide (another H2O2-dependent catalase blocker) also showed a dose-dependent reduction of the obtained. |
34(0,1,1,4) | Details |
| 17597213 | Jamal M, Ameno K, Uekita I, Kumihashi M, Wang W, Ijiri I: Catalase mediates formation in the striatum of free-moving rats. Biochem Pharmacol. 1988 Jan 15;37(2):229-34. Rats received intraperitoneal EtOH (1g/kg) alone or in combination with 4-methylpyrazole (MP, 82 mg/kg, an alcohol dehydrogenase inhibitor), and/or catalase inhibitor azide (AZ, 10mg/kg) or 3-amino-1,2,4-triazole (AT, 1g/kg), and/or cyanamide (CY, 50mg/kg, an aldehyde dehydrogenase inhibitor). |
34(0,1,1,4) | Details |
| 1443429 | Gill K, Menez JF, Lucas D, Deitrich RA: Enzymatic production of from in rat brain tissue. Alcohol Clin Exp Res. 1992 Oct;16(5):910-5. On the other hand, treatment with the catalase inhibitors azide, cyanamide, or 3-amino-1,2,4-triazole blocked the production of AcHO while the addition of exogenous peroxide or a peroxide-generating system enhanced the production of AcHO. |
32(0,1,1,2) | Details |
| 10680717 | Shoeman DW, Shirota FN, DeMaster EG, Nagasawa HT: Reaction of an aldehyde dehydrogenase inhibitor, with N-acetyl- Alcohol. 2000 Jan;20(1):55-9. (HNO) is the aldehyde dehydrogenase (AIDH) inhibitor produced by catalase action on cyanamide. |
31(0,1,1,1) | Details |
| 6992725 | Lamboeuf Y, De Saint Blanquat G: Effects of cyanamide and clofibrate on the enzymes of oxydation and on consumption in the rat. Toxicol Lett. 1985 Dec;29(2-3):107-14. Both substances reduce consumption by about 35% and cause metabolic modifications: inhibition of aldehyde dehydrogenase and of catalase by cyanamide; activation of - and aldehyde-dehydrogenases by clofibrate. |
31(0,1,1,1) | Details |
| 10780252 | Sanchis-Segura C, Miquel M, Correa M, Aragon CM: Daily injections of cyanamide enhance both -induced locomotion and brain catalase activity. Behav Pharmacol. 1999 Sep;10(5):459-65. |
21(0,0,3,6) | Details |
| 16664957 | Nir G, Shulman Y, Fanberstein L, Lavee S: Changes in the Activity of Catalase (EC 1.11.1.6) in Relation to the Dormancy of Grapevine (Vitis vinifera L.) Buds. Plant Physiol. 1986 Aug;81(4):1140-1142. Efficient buddormancy breaking agents, such as thiourea and cyanamide decreased catalase activity to 64 and 50% of the controls respectively, while the activity of peroxidase remained the same under those conditions. |
12(0,0,1,7) | Details |
| 11495670 | Correa M, Sanchis-Segura C, Aragon CM: Brain catalase activity is highly correlated with -induced locomotor activity in mice. Biochem Biophys Res Commun. 1989 Aug 30;163(1):527-33. |
9(0,0,0,9) | Details |
| 3335049 | Lambert CE, Shank RC: Role of hydrazone and catalase in hydrazine-induced methylation of DNA Carcinogenesis. 1988 Jan;9(1):65-70. However, azide, cyanamide and all inhibited S9-supported DNA methylation. |
3(0,0,0,3) | Details |
| 15832682 | Perez FJ, Lira W: Possible role of catalase in post-dormancy bud break in grapevines. Biochem Pharmacol. 1994 Mar 2;47(5):922-4. Three isoforms of Cat were detected in extracts of buds by native PAGE analysis, and the extracted activity was inhibited competitively by cyanamide (HC), a potent bud-break agent. |
2(0,0,0,2) | Details |
| 8394073 | Mattia CJ, Adams JD Jr, Bondy SC: Free radical induction in the brain and liver by products of toluene catabolism. 198-9. Incubation of benzaldehyde with aldehyde dehydrogenase produced a strong signal that was blocked completely by superoxide dismutase and inhibited partially by catalase, suggesting the presence of radicals and the involvement of the iron-catalyzed Haber-Weiss reaction leading to the production of Pretreatment of rats in vivo with 4-methylpyrazole, an alcohol dehydrogenase inhibitor, or cyanamide, an aldehyde dehydrogenase inhibitor, prior to exposure to toluene, caused a significant decrease and increase, respectively, in toluene-stimulated rates of ROS generation in the CNS and liver. |
1(0,0,0,1) | Details |
| 9191964 | Shirota FN, Stevens-Johnk JM, DeMaster EG, Nagasawa HT: Novel prodrugs of cyanamide that inhibit aldehyde dehydrogenase in vivo. J Med Chem. 1997 Jun 6;40(12):1870-5. In support of this, when 8 was incubated in vitro with rat liver microsomes coupled to catalase and yeast A1DH, the requirement for microsomal activation for the inhibition of A1DH activity was clearly indicated. |
1(0,0,0,1) | Details |
| 3508430 | Younes M, Strubelt O: -induced hepatotoxicity: a role for free radicals. Free Radic Res Commun. 1987;3(1-5):19-26. Inhibition of alcohol dehydrogenase by 4-methylpyrazole or of aldehyde dehydrogenase by cyanamide totally abolished hepatotoxicity despite of a severalfold increase in concentration in the perfusate. Addition of superoxide dismutase or catalase clearly suppressed the -induced release of GPT and SDH, suggesting that .O2- and H2O2 are involved in this process. |
1(0,0,0,1) | Details |
| 12655465 | Escarabajal MD, De Witte P, Quertemont E: Role of in -induced conditioned taste aversion in rats. Biochem Pharmacol. 1986 Jul 1;35(13):2081-5. Our results also suggest that the inhibition of brain catalase activity may contribute to the potentiating effects of cyanamide on ethanol-induced CTA. In a second experiment, cyanamide, an aldehyde dehydrogenase inhibitor, was administered before conditioning with either or to investigate the effects of accumulation. |
1(0,0,0,1) | Details |
| 8678898 | Shirota FN, Goon DJ, DeMaster EG, Nagasawa HT: Nitrosyl a putative metabolic oxidation product of the -deterrent agent cyanamide. Biochem Pharmacol. 1993 Jul 6;46(1):103-10. N-hydroxycyanamide, was being further oxidized by catalase/H2O2 to nitrosyl (O = N-C = N). |
1(0,0,0,1) | Details |
| 11900810 | Escarabajal MD, Aragon CM: The effect of cyanamide and 4-methylpyrazole on the -induced locomotor activity in mice. Pharmacol Biochem Behav. 2002 May;72(1-2):389-95. These data might suggest some influence of brain catalase and aldehyde dehydrogenase (ALDH) on the effects of |
1(0,0,0,1) | Details |