Protein Information

Name 5 HT2
Synonyms 5 HT 2; 5 HT 2A; 5 HT2; 5 HT2A; 5 hydroxytryptamine (serotonin) receptor 2A; 5 hydroxytryptamine 2A receptor; 5 hydroxytryptamine receptor 2A; HTR 2…

Compound Information

Name cyanamide
CAS cyanamide

Reference List

PubMed Abstract RScore(About this table)
8848457 Long TA, Kalmus GW, Bjork A, Myers RD: Alcohol intake in high alcohol drinking (HAD) rats is suppressed by FG5865, a novel 5-HT1A agonist/5-HT2 antagonist. Pharmacol Biochem Behav. 1996 Jan;53(1):33-40.

Both the 5-HT2 antagonist, FG5606 (amperozide), and the mixed 5-HT1 agonist/5-HT2 antagonist, FG5893, attenuate significantly the volitional intake of alcohol in the cyanamide treated rat.
34(0,1,1,4) Details
8836330 Lankford MF, Bjork AK, Myers RD: Differential efficacy of serotonergic drugs FG5974, FG5893, and amperozide in reducing alcohol drinking in P rats. Alcohol. 1996 Jul-Aug;13(4):399-404.

The mixed 5-HT1A agonist/5-HT2A antagonist, FG5893, which suppresses drinking in cyanamide-treated rats, was without effect on alcohol ingested by the P rats.
33(0,1,1,3) Details
8507395 Singh GK, Kalmus GW, Bjork AK, Myers RD: Alcohol drinking in rats is attenuated by the mixed 5-HT1 agonist/5-HT2 antagonist FG 5893. Alcohol. 1993 May-Jun;10(3):243-8.

Recently, the 5-HT2 antagonist amperozide was found to reduce selectively the high intake of alcohol in the cyanamide-induced drinking rat without any adverse side effects.
33(0,1,1,3) Details
8442888 Myers RD, Lankford M, Bjork A: Irreversible suppression of alcohol drinking in cyanamide-treated rats after sustained delivery of the 5-HT2 antagonist amperozide. Alcohol. 1993 Mar-Apr;10(2):117-25.
31(0,1,1,1) Details
8060520 McMillen BA, Walter S, Williams HL, Myers RD: Comparison of the action of the 5-HT2 antagonists amperozide and trazodone on preference for alcohol in rats. Alcohol. 1994 May-Jun;11(3):203-6.

Male Sprague-Dawley rats were induced to drink alcohol by 10 mg/kg cyanamide injected for 3 days b.i.d.
4(0,0,0,4) Details
8516364 Myers RD, Lankford MF: Failure of the 5-HT2 receptor antagonist, ritanserin, to alter preference for alcohol in drinking rats. Pharmacol Biochem Behav. 1993 May;45(1):233-7.

Following the repeated administration of the inhibitor of aldehyde dehydrogenase, cyanamide, the preference for alcohol vs. water was determined in each of 20 Sprague-Dawley rats by a standard test using 3-30% concentrations.
3(0,0,0,3) Details
8332634 Myers RD, Lankford MF, Bjork A: 5-HT2 receptor blockade by amperozide suppresses ethanol drinking in genetically preferring rats. Pharmacol Biochem Behav. 1993 Jul;45(3):741-7.

Previously, it was shown that the unique diphenylbutylpiperazinecarboxamide derivative, amperozide (FG 5606), inhibits the volitional drinking of ethanol induced in the rat by the inhibitor of aldehyde dehydrogenase, cyanamide.
2(0,0,0,2) Details