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Carini R, De Cesaris MG, Spendore R, Albano E: Ethanol potentiates hypoxic liver injury: role of hepatocyte Na (+) overload. Biochim Biophys Acta. 2000 Nov 15;1502(3):508-14.
Moreover, ethanol-induced Na (+) influx caused cytotoxicity in hepatocytes pre-treated with Na (+), K (+)-ATPase inhibitor ouabain.
Inhibiting ethanol and acetaldehyde oxidation with, respectively, 4-methylpyrazole and cyanamide prevented this effect. 4-methylpyrazole, cyanamide as well as hepatocyte incubation in a HCO (3)(-)-free buffer or in the presence of Na (+)/H (+) exchanger blocker 5-(N,N-dimethyl)-amiloride also reduced Na (+) influx in ethanol-treated hepatocytes. 4-methylpyrazole and cyanamide similarly prevented ethanol-stimulated Na (+) accumulation and hepatocyte killing during hypoxia. |
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