| 6417079 |
Fox RB, Harada RN, Tate RM, Repine JE: Prevention of thiourea-induced pulmonary edema by hydroxyl-radical scavengers. J Appl Physiol. 1983 Nov;55(5):1456-9.
To test the hypothesis that TU-induced lung injury results from .OH-mediated oxidation of TU to toxic cyanamide, we pretreated rats with .OH scavengers, dimethylsulfoxide (DMSO), ethanol, and mannitol, prior to treatment with TU (3 mg/kg), preventing 91, 63, and 53%, respectively, of increases in lung weight to body weight ratios and 93, 67, and 46% of increases in lung lavage albumin concentrations. |
31(0,1,1,1) |
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