Protein Information

Name PPARalpha
Synonyms NR1C1; PPAR; PPAR alpha; PPARA; PPARalpha; Peroxisome proliferator activated receptor; Peroxisome proliferator activated receptor alpha; hPPAR…

Compound Information

Name cyanamide
CAS cyanamide

Reference List

PubMed Abstract RScore(About this table)
18003597 Venkata NG, Aung CS, Cabot PJ, Monteith GR, Roberts-Thomson SJ: PPARalpha and PPARbeta are differentially affected by ethanol and the ethanol metabolite acetaldehyde in the MCF-7 breast cancer cell line. Toxicol Sci. 2008 Mar;102(1):120-8. Epub 2007 Nov 13.

Using the enzyme inhibitors 4-methylpyrazole and cyanamide and the metabolite acetaldehyde, we showed that PPARalpha and PPARbeta are differentially modulated by ethanol and acetaldehyde.
86(1,1,1,6) Details
11022051 Galli A, Pinaire J, Fischer M, Dorris R, Crabb DW: The transcriptional and DNA binding activity of peroxisome proliferator-activated receptor alpha is inhibited by ethanol metabolism. J Biol Chem. 2001 Jan 5;276(1):68-75.

This effect of ethanol was abolished by the alcohol dehydrogenase inhibitor 4-methylpyrazole and augmented by the aldehyde dehydrogenase inhibitor cyanamide, indicating that acetaldehyde was responsible for the action of ethanol.
6(0,0,0,6) Details