Protein Information

Name glutathione S transferase
Synonyms GST class alpha 2; Gst2; GST class alpha; GST class alpha member 2; GST gamma; GSTA 2; GSTA2; GSTA2 2…

Compound Information

Name cyanamide
CAS cyanamide

Reference List

PubMed Abstract RScore(About this table)
18324412 Halaly T, Pang X, Batikoff T, Crane O, Keren A, Venkateswari J, Ogrodovitch A, Sadka A, Lavee S, Or E: Similar mechanisms might be triggered by alternative external stimuli that induce dormancy release in grape buds. Planta. 2008 Jun;228(1):79-88. Epub 2008 Mar 7.

To test the hypothesis that temporary oxidative stress is part of the mechanism inducing dormancy release, we analyzed the effect of HS and HC treatments on the expression of ascorbate peroxidase, glutathione reductase, thioredoxin h, glutathione S-transferase and sucrose synthase genes and found that they were induced by both treatments in a similar pattern.
We compared the effects of heat shock (HS) and hydrogen cyanamide (HC) and demonstrated that HS leads to earlier and higher bud-break levels.
1(0,0,0,1) Details
19576883 Zhang XJ, Chang L, Zhang YM, Deng S, Li YJ, Peng J: Comparing the role of glutathione-S-transferase and mitochondrial aldehyde dehydrogenase in nitroglycerin biotransformation and the correlation with calcitonin gene-related peptide. Eur J Pharmacol. 2009 Sep 1;617(1-3):97-101. Epub 2009 Jul 2.

The inhibitor of GST (ethacrynic acid) or ALDH-2 (cyanamide) was given before nitroglycerin treatment; In vitro, the isolated aorta rings were incubated with nitroglycerin to obtain the concentration-response curve.
2(0,0,0,2) Details
16540368 Gyamfi MA, Wan YJ: The effect of ethanol, ethanol metabolizing enzyme inhibitors, and Vitamin E on regulating glutathione, glutathione S-transferase, and S-adenosylmethionine in mouse primary hepatocyte. Hepatol Res. 2006 May;35(1):53-61. Epub 2006 Mar 15.

Lipid peroxidation (LPO), assessed by the thiobarbituric acid assay, increased to 221% of control by ethanol and was potentiated by cyanamide, an aldehyde dehydrogenase inhibitor.
2(0,0,0,2) Details
7840616 Hartley DP, Ruth JA, Petersen DR: The hepatocellular metabolism of 4-hydroxynonenal by alcohol dehydrogenase, aldehyde dehydrogenase, and glutathione S-transferase. Arch Biochem Biophys. 1995 Jan 10;316(1):197-205.

The presence of 4-methylpyrazole or cyanamide abolished formation of the reductive metabolite 1,4-dihydroxy-2-nonene or the oxidative metabolite 4-hydroxy-2-nonenoic acid in hepatocyte suspensions.
2(0,0,0,2) Details
19651683 Walton EF, Wu RM, Richardson AC, Davy M, Hellens RP, Thodey K, Janssen BJ, Gleave AP, Rae GM, Wood M, Schaffer RJ: A rapid transcriptional activation is induced by the dormancy-breaking chemical hydrogen cyanamide in kiwifruit (Actinidia deliciosa) buds. J Exp Bot. 2009;60(13):3835-48. Epub 2009 Aug 3.

One group of genes that was rapidly up-regulated in response to HC was the glutathione S-transferase (GST) class of genes, which have been associated with stress and signalling.
1(0,0,0,1) Details