Protein Information

Name brains
Synonyms BPG dependent PGAM 1; Brain; CDABP0006; PGAM 1; PGAM B; PGAM1; PGAM1 protein; PGAMA…

Compound Information

Name cyanamide
CAS cyanamide

Reference List

PubMed Abstract RScore(About this table)
1443429 Gill K, Menez JF, Lucas D, Deitrich RA: Enzymatic production of acetaldehyde from ethanol in rat brain tissue. Alcohol Clin Exp Res. 1992 Oct;16(5):910-5.

Rat brains were perfused with saline-heparin solution and homogenized in a phosphate buffer.
On the other hand, treatment with the catalase inhibitors sodium azide, cyanamide, or 3-amino-1,2,4-triazole blocked the production of AcHO while the addition of exogenous peroxide or a peroxide-generating system enhanced the production of AcHO.
1(0,0,0,1) Details
1632841 Aragon CM, Rogan F, Amit Z: Ethanol metabolism in rat brain homogenates by a catalase-H2O2 system. Biochem Pharmacol. 1992 Jul 7;44(1):93-8.

Homogenates of perfused brains of rats treated with 3-amino-1,2,4-triazole or cyanamide (another H2O2-dependent catalase blocker) also showed a dose-dependent reduction of the acetaldehyde obtained.
32(0,1,1,2) Details
2058789 Aragon CM, Stotland LM, Amit Z: Studies on ethanol-brain catalase interaction: evidence for central ethanol oxidation. Alcohol Clin Exp Res. 1991 Mar;15(2):165-9.

In a second study, homogenates from perfused brains were incubated in the presence of glucose and glucose oxidase with ethanol or saline and cyanamide or saline.
6(0,0,1,1) Details
7159468 Hellstrom E, Tottmar O: Effects of aldehyde dehydrogenase inhibitors on enzymes involved in the metabolism of biogenic aldehydes in rat liver and brain. Biochem Pharmacol. 1982 Dec 1;31(23):3899-905.

The effects of the aldehyde dehydrogenase inhibitors disulfiram, coprine and cyanamide on enzymes involved in the metabolism of biogenic aldehydes in rat liver and brain were studied.
None of the drugs caused any changes in the activities of aldehyde reductase and monoamine oxidase in brains in vivo.
1(0,0,0,1) Details
8394073 Mattia CJ, Adams JD Jr, Bondy SC: Free radical induction in the brain and liver by products of toluene catabolism. Biochem Pharmacol. 1993 Jul 6;46(1):103-10.


Pretreatment of rats in vivo with 4-methylpyrazole, an alcohol dehydrogenase inhibitor, or sodium cyanamide, an aldehyde dehydrogenase inhibitor, prior to exposure to toluene, caused a significant decrease and increase, respectively, in toluene-stimulated rates of ROS generation in the CNS and liver.
0(0,0,0,0) Details