Protein Information

Name AHAS
Synonyms 209L8; AHAS; Acetolactate synthase; Acetolactate synthase homolog; ILV2H; ILVB like; ILVBL; IlvB (Bacterial acetolactate synthase) like isoform 1 variant…

Compound Information

Name tribenuron
CAS 2-[[[[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)methylamino]carbonyl]amino]sulfonyl]benzoic acid

Reference List

PubMed Abstract RScore(About this table)
15709745 McCourt JA, Pang SS, Guddat LW, Duggleby RG: Elucidating the specificity of binding of sulfonylurea herbicides to acetohydroxyacid synthase. Biochemistry. 2005 Feb 22;44(7):2330-8.

Here we report crystal structures of yeast AHAS in complex with chlorsulfuron (at a resolution of 2.19 A), sulfometuron methyl (2.34 A), and two other sulfonylureas, metsulfuron methyl (2.29 A) and tribenuron methyl (2.58 A).
34(0,1,1,4) Details
18784913 Sala CA, Bulos M, Echarte M, Whitt SR, Ascenzi R: Molecular and biochemical characterization of an induced mutation conferring imidazolinone resistance in sunflower. Theor Appl Genet. 2008 Dec;118(1):105-12. Epub 2008 Sep 11.

CLHA-Plus showed a complete susceptibility to sulfonylureas (metsulfuron, tribenuron and chlorsulfuron) but, on the other hand, it showed a complete resistance to imidazolinones (imazamox, imazapyr and imazapic) at two rates of herbicide application.
This pattern was in close association with the AHAS-inhibition kinetics of protein extracts of CLHA-Plus challenged with different doses of imazamox and chlorsulfuron.
4(0,0,0,4) Details