| Name | CGRP |
|---|---|
| Synonyms | Alpha type CGRP; CT; CGRP; CALC 1; CALC1; CALCA; CGRP 1; CGRP I… |
| Name | acrolein |
|---|---|
| CAS | 2-propenal |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19371406 | Forster AB, Reeh PW, Messlinger K, Fischer MJ: High concentrations of morphine sensitize and activate mouse dorsal root ganglia via TRPV1 and TRPA1 receptors. Mol Pain. 2009 Apr 16;5:17. RESULTS: Morphine induced release of calcitonin gene-related peptide and sensitized the release evoked by heat or the TRPA1 agonist acrolein. |
32(0,1,1,2) | Details |
| 1696540 | Springall DR, Edginton JA, Price PN, Swanston DW, Noel C, Bloom SR, Polak JM: Acrolein depletes the neuropeptides CGRP and substance P in sensory nerves in rat respiratory tract. Environ Health Perspect. 1990 Apr;85:151-7. |
14(0,0,2,4) | Details |
| 17684094 | Trevisani M, Siemens J, Materazzi S, Bautista DM, Nassini R, Campi B, Imamachi N, Andre E, Patacchini R, Cottrell GS, Gatti R, Basbaum AI, Bunnett NW, Julius D, Geppetti P: an endogenous causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1. Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13519-24. Epub 2007 Aug 7. TRPA1 is an excitatory ion channel expressed by a subpopulation of primary afferent somatosensory neurons that contain substance P and calcitonin gene-related peptide. Environmental irritants such as mustard oil, allicin, and acrolein activate TRPA1, causing acute pain, neuropeptide release, and neurogenic inflammation. |
2(0,0,0,2) | Details |
| 17991581 | Du S, Araki I, Yoshiyama M, Nomura T, Takeda M: Transient receptor potential channel A1 involved in sensory transduction of rat urinary bladder through C-fiber pathway. Urology. 2007 Oct;70(4):826-31. TRPA1 and calcitonin-gene related peptide were co-localized in subepithelial sensory nerves of the bladder. |
1(0,0,0,1) | Details |
| 18468780 | Gratzke C, Streng T, Waldkirch E, Sigl K, Stief C, Andersson KE, Hedlund P: Transient receptor potential A1 (TRPA1) activity in the human urethra--evidence for a functional role for TRPA1 in the outflow region. Eur Urol. 2009 Mar;55(3):696-704. Epub 2008 Apr 30. CONCLUSIONS: The localization of TRPA1 to nerves that also express TRPV1 and CGRP, and in urothelial cells and interstitial cells, as well as the findings that TRPA1 agonists can modify tone of urethral preparations, propose a role for TRPA1 in afferent and efferent sensory signaling of the human outflow region. |
1(0,0,0,1) | Details |
| 18307678 | Geppetti P, Nassini R, Materazzi S, Benemei S: The concept of neurogenic inflammation. BJU Int. 2008 Mar;101 Suppl 3:2-6. Neurogenic inflammation encompasses a series of vascular and non-vascular inflammatory responses, triggered by the activation of primary sensory neurons and the subsequent release of inflammatory neuropeptides, including substance P and calcitonin gene-related peptide. Involvement of the TRP cation channel, subfamily A, member 1 (TRPA1) has also been reported in models of neurogenic inflammation and nociception promoted by the cyclophosphamide metabolite, acrolein. |
1(0,0,0,1) | Details |
| 1613209 | Maggi CA, Lecci A, Santicioli P, Del Bianco E, Giuliani S: Cyclophosphamide cystitis in rats: involvement of -sensitive primary afferents. J Auton Nerv Syst. 1992 May 15;38(3):201-8. The bladder content of calcitonin gene-related peptide, used as a marker of the bladder afferent fibres that are -sensitive in adult rats, was slightly reduced as compared to controls, but the difference can be accounted for by the increased bladder weight. |
1(0,0,0,1) | Details |