| Name | prothrombin |
|---|---|
| Synonyms | Coagulation factor II; Coagulation factor II variant; F2; F2 protein; F2 protein precursor; Factor II; PT; Prothrombin… |
| Name | acrolein |
|---|---|
| CAS | 2-propenal |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 8423767 | Karolak L, Chandra A, Khan W, Marks B, Petros WP, Peters WP, Greenberg CS, Hannun YA: High-dose chemotherapy-induced platelet defect: inhibition of platelet signal transduction pathways. Mol Pharmacol. 1993 Jan;43(1):37-44. Acrolein inhibited thrombin- and phorbol ester-induced phosphorylation of a 40-kDa polypeptide and other substrates, indicating a cellular defect in protein kinase C signaling. |
81(1,1,1,1) | Details |
| 2118426 | Selley ML, Bartlett MR, McGuiness JA, Ardlie NG: Effects of acrolein on human platelet aggregation. Chem Biol Interact. 1990;76(1):101-9. Acrolein, a component of tobacco smoke, potentiated platelet aggregation and increased formation caused by thrombin and (AA). |
12(0,0,2,2) | Details |
| 16626787 | Huang J, Wang S, Luo X, Xie Y, Shi X: reduction of platelet aggregation and thrombosis in rodents. Thromb Res. 2007;119(3):337-42. Epub 2006 Apr 19. MATERIALS AND METHODS: We tested the effects of CA on collagen- or thrombin-induced aggregation of rat platelets in vitro. |
2(0,0,0,2) | Details |
| 3133806 | Selley ML, McGuiness JA, Jenkin LA, Bartlett MR, Ardlie NG: Effect of 4--2,3-trans-nonenal on platelet function. . Thromb Haemost. 1988 Apr 8;59(2):143-6. 4-Hydroxy-2,3-trans-nonenal (HNE), an end-product of lipid peroxidation, potentiated aggregation and increased formation in platelets challenged with ADP, thrombin or the ionophore A23187. |
1(0,0,0,1) | Details |
| 6711319 | Poulsen HE, Korsholm B: Quantitative liver functions after administration of allyl to rats. Acta Pharmacol Toxicol. 1984 Feb;54(2):120-3. Prothrombin index was reduced to a minimum after 12 hours and reestablished after 24 hours. |
1(0,0,0,1) | Details |
| 17079160 | Ballabeni V, Tognolini M, Bertoni S, Bruni R, Guerrini A, Rueda GM, Barocelli E: Antiplatelet and antithrombotic activities of essential oil from wild Ocotea quixos (Lam.) Kosterm. (Lauraceae) calices from Amazonian Ecuador. Pharmacol Res. 2007 Jan;55(1):23-30. Epub 2006 Sep 29. In vitro Ocotea essential oil and inhibited -, U46619-, ADP-, phorbol12-myristate13-alcetate-, collagen-induced platelet aggregation and thrombin-induced clot retraction in human and rodent plasma; Ocotea oil and competitively antagonized contractions induced by thromboxane A2 receptor agonist U46619 in rat isolated aortic ring (K (B) = 18 and 3.2 microg ml (-1), respectively). |
1(0,0,0,1) | Details |