Protein Information

Name Fas receptor
Synonyms ALPS1A; APT1; FAS; APO 1; APO 1 cell surface antigen; APO1; Apo 1 Fas; Apo 1 antigen…

Compound Information

Name acrolein
CAS 2-propenal

Reference List

PubMed Abstract RScore(About this table)
17320762 Tanel A, Averill-Bates DA: Activation of the death receptor pathway of apoptosis by the aldehyde acrolein. Free Radic Biol Med. 2007 Mar 15;42(6):798-810. Epub 2006 Dec 14.

Inhibition of activation of either the Fas receptor or caspase-8 partially decreased acrolein-induced caspase-9 activation.
94(0,3,3,4) Details
17222828 Hristova M, Heuvelmans S, van der Vliet A: GSH-dependent regulation of Fas-mediated caspase-8 activation by acrolein. . FEBS Lett. 2007 Feb 6;581(3):361-7. Epub 2007 Jan 12.

Activation of the cysteine protease caspase-8 by the death receptor Fas (CD95/APO-1) in B lymphoblastoid SKW6.4 cells or Jurkat T cells is associated with GSH depletion.
1(0,0,0,1) Details
11342443 Fonseca AM, Porto G, Uchida K, Arosa FA: Red blood cells inhibit activation-induced cell death and oxidative stress in human peripheral blood T lymphocytes. Blood. 2001 May 15;97(10):3152-60.


Studies aimed at characterizing the cellular and molecular basis of the protection afforded to T cells by RBCs showed that (1) optimal protection required intact RBCs and red cell/T-cell contact but not monocytes; (2) RBCs markedly reduced the level of intracellular reactive oxygen species; and (3) RBCs inhibited the formation of protein-bound acrolein, a peroxidation adduct in biologic systems.
0(0,0,0,0) Details