| Name | ICAD |
|---|---|
| Synonyms | DFF 45; DFF 1; DFF1; DFF45; DFFA; DNA fragmentation factor 45; DNA fragmentation factor 45 kDa subunit; DNA fragmentation factor alpha subunit… |
| Name | acrolein |
|---|---|
| CAS | 2-propenal |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17196791 | Tanel A, Averill-Bates DA: P38 and ERK mitogen-activated protein kinases mediate acrolein-induced apoptosis in Chinese hamster ovary cells. Cell Signal. 2007 May;19(5):968-77. Epub 2006 Nov 25. Thus, blockade of ERK and p38 inhibited chromatin condensation, caspase-7 and -9 activation as well as ICAD cleavage induced by acrolein. |
81(1,1,1,1) | Details |
| 15843039 | Tanel A, Averill-Bates DA: The acrolein induces apoptosis via activation of the mitochondrial pathway. Biochim Biophys Acta. 2005 Apr 15;1743(3):255-67. Epub 2005 Jan 5. The induction of apoptosis by acrolein was confirmed morphologically by the condensation of nuclear chromatin and by the cleavage of the inhibitor of caspase activated DNase (ICAD), which leads to the liberation of CAD that causes DNA fragmentation. |
31(0,1,1,1) | Details |