| 17907782 |
Burcham PC, Raso A, Thompson C, Tan D: Intermolecular protein cross-linking during acrolein toxicity: efficacy of carbonyl scavengers as inhibitors of heat shock protein-90 cross-linking in A549 cells. Chem Res Toxicol. 2007 Nov;20(11):1629-37. Epub 2007 Oct 2.
Because little information is available concerning the extent of intermolecular protein cross-linking during acrolein toxicity in cells, we used an antibody against a known target for toxic carbonyls, the chaperone protein Hsp90, to detect the formation of high-mass protein complexes in acrolein-exposed A549 cells. |
225(2,4,4,5) |
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| 19686041 |
Burcham PC, Raso A, Thompson CA: Intermediate filament carbonylation during acute acrolein toxicity in A549 lung cells: functional consequences, chaperone redistribution, and protection by bisulfite. Antioxid Redox Signal. 2010 Mar;12(3):337-47.
The carbonyl scavenger bisulfite suppressed acrolein toxicity, intermediate filament adduction, vimentin cross-linking, Hsp90 redistribution, and loss of cellular adhesive strength, while also suppressing vimentin hyperphosphorylation. |
31(0,1,1,1) |
Details |