| Name | PERK |
|---|---|
| Synonyms | EIF 2 alpha kinase 3; WRS; EIF2AK3; Eukaryotic translation initiation factor 2 alpha kinase 3; Eukaryotic translation initiation factor 2 alpha kinase 3 precursor; HsPEK; PEK; PERK… |
| Name | acrolein |
|---|---|
| CAS | 2-propenal |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19041636 | Keith RJ, Haberzettl P, Vladykovskaya E, Hill BG, Kaiserova K, Srivastava S, Barski O, Bhatnagar A: Aldose reductase decreases endoplasmic reticulum stress in ischemic hearts. Chem Biol Interact. 2009 Mar 16;178(1-3):242-9. Epub 2008 Nov 11. In cell culture experiments, exposure to model lipid peroxidation aldehydes-4-hydroxy-trans-2-nonenal (HNE), 1-palmitoyl-2-oxovaleroyl (POVPC) or acrolein led to an increase in the phosphorylation of ER stress markers PERK and eIF2-alpha and an increase in ATF3. |
83(1,1,1,3) | Details |
| 18206657 | Hengstermann A, Muller T: Endoplasmic reticulum stress induced by aqueous extracts of cigarette smoke in 3T3 cells activates the unfolded-protein-response-dependent PERK pathway of cell survival. Free Radic Biol Med. 2008 Mar 15;44(6):1097-107. Epub 2007 Dec 23. Notably however, the effects of aqueous extracts of CS on the ER could be mimicked in the presence of acrolein at CS-relevant concentrations, indicating that CS interferes with proper ER function, presumably due mainly to changes in cellular redox homeostasis. |
3(0,0,0,3) | Details |