| Name | 5 lipoxygenase |
|---|---|
| Synonyms | 5 lipoxygenase; 5 LO; 5LPG; ALOX 5; ALOX5; Arachidonate 5 lipoxygenase; Arachidonate 5 lipoxygenase variant; LOG 5… |
| Name | acrolein |
|---|---|
| CAS | 2-propenal |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 20153347 | Kim CE, Lee SJ, Seo KW, Park HM, Yun JW, Bae JU, Bae SS, Kim CD: Acrolein increases 5-lipoxygenase expression in murine macrophages through activation of ERK pathway. Toxicol Appl Pharmacol. 2010 Feb 11. Episodic exposure to acrolein-rich pollutants has been linked to acute myocardial infarction, and 5-lipoxygenase (5-LO) is involved in the production of matrix metalloproteinase-9 (MMP-9), which destabilizes atherosclerotic plaques. |
255(2,5,5,5) | Details |
| 19548361 | Berry KA, Henson PM, Murphy RC: Effects of acrolein on leukotriene biosynthesis in human neutrophils. . Chem Res Toxicol. 2008 Dec;21(12):2424-32. A dose-dependent decrease in the formation of 5-LO products was observed in GM-CSF/fMLP-stimulated neutrophils when acrolein (0-50 microM) was present with almost complete inhibition at > or = 25 microM acrolein. |
38(0,1,2,3) | Details |
| 2543658 | Leikauf GD, Doupnik CA, Leming LM, Wey HE: Sulfidopeptide leukotrienes mediate acrolein-induced bronchial hyperresponsiveness. J Appl Physiol. 1989 Apr;66(4):1838-45. The objective of this study was to determine if treatment with a leukotriene receptor antagonist and 5-lipoxygenase inhibitors could diminish acrolein-induced bronchial hyperresponsiveness and to determine whether leukotriene (LT) C4 generation is augmented by acrolein exposure. |
32(0,1,1,2) | Details |
| 8381676 | Fruteau de Laclos B, Zirrolli JA, Murphy RC: Collision-induced dissociation of carboxylate anions from derivatized 5-lipoxygenase metabolites of Biol Mass Spectrom. 1993 Jan;22(1):9-18. The carboxylate anion of 5-HEA (m/z 399) was found to decompose by the loss of trimethylsilanol as well as the loss of 146 u corresponding to the loss of trimethylsilanol followed by acrolein, a process specific for 5--containing saturated fatty acids. |
2(0,0,0,2) | Details |
| 19501497 | Raghavendra RH, Naidu KA: Spice active principles as the inhibitors of human platelet aggregation and biosynthesis. Prostaglandins Leukot Essent Fatty Acids. 2009 Jul;81(1):73-8. Epub 2009 Jun 6. In our previous report we have shown that spices and their active principles inhibit 5-lipoxygenase and also formation of |
1(0,0,0,1) | Details |