Protein Information

Name MUC5B
Synonyms High molecular weight salivary mucin MG1; MUC5; MG1; MUC 5; MUC 9; MUC5B; MUC9; Mucin 5B…

Compound Information

Name acrolein
CAS 2-propenal

Reference List

PubMed Abstract RScore(About this table)
12010847 Leikauf GD, Borchers MT, Prows DR, Simpson LG: Mucin apoprotein expression in COPD. . Chest. 2002 May;121(5 Suppl):166S-182S.

Recent studies with acrolein and cigarette smoke have suggested that MUC5AC is inducible (accompanied by epidermal growth factor [EGF] ligand formation and the activation of EGF receptor-dependent pathways), whereas MUC5B is constitutively expressed (increasing through gland enlargement).
82(1,1,1,2) Details
10198352 Borchers MT, Carty MP, Leikauf GD: Regulation of human airway mucins by acrolein and inflammatory mediators. Am J Physiol. 1999 Apr;276(4 Pt 1):L549-55.

To determine whether acrolein and inflammatory mediators alter mucin gene expression, steady-state mRNA levels of two airway mucins, MUC5AC and MUC5B, were measured (by RT-PCR) in human lung carcinoma cells (NCI-H292).
7(0,0,1,2) Details