| Name | glutathione transferases |
|---|---|
| Synonyms | GST class mu 2; GST 4; GST4; GSTM; GSTM 2; GSTM2; GSTM2 2; GSTmu3… |
| Name | acrolein |
|---|---|
| CAS | 2-propenal |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 2304453 | Berhane K, Mannervik B: Inactivation of the genotoxic acrolein by human glutathione transferases of classes alpha, mu, and pi. Mol Pharmacol. 1990 Feb;37(2):251-4. |
243(3,3,3,3) | Details |
| 8108434 | Berhane K, Widersten M, Engstrom A, Kozarich JW, Mannervik B: Detoxication of base propenals and other alpha, beta-unsaturated products of radical reactions and lipid peroxidation by human glutathione transferases. Proc Natl Acad Sci U S A. 1994 Feb 15;91(4):1480-4. GST P1-1 introduced into Hep G2 cells by electroporation was similarly found to increase their resistance to acrolein. |
3(0,0,0,3) | Details |
| 1599415 | Stenberg G, Ridderstrom M, Engstrom A, Pemble SE, Mannervik B: Cloning and heterologous expression of cDNA encoding class alpha rat glutathione transferase 8-8, an enzyme with high catalytic activity towards genotoxic alpha,beta-unsaturated carbonyl compounds. Biochem J. 1992 Jun 1;284 ( Pt 2):313-9. The highest activity was obtained with 4-hydroxyalkenals and with acrolein, genotoxic products of lipid peroxidation. |
3(0,0,0,3) | Details |
| 9772203 | He NG, Awasthi S, Singhal SS, Trent MB, Boor PJ: The role of glutathione S-transferases as a defense against reactive electrophiles in the blood vessel wall. Toxicol Appl Pharmacol. 1998 Sep;152(1):83-9. The glutathione transferases (GSTs) are a family of ubiquitous enzymes that catalyze the conjugation of (GSH) with reactive electrophiles. In this study we examined the role of GSTs in providing protection to cultured neonatal vascular smooth muscle cells (VSMCs) from the alpha,beta-unsaturated carbonyl cardiovascular toxins, allylamine and its metabolite, acrolein. |
1(0,0,0,1) | Details |
| 12399159 | Kapetanovic IM, Torchin CD, Strong JM, Yonekawa WD, Lu C, Li AP, Dieckhaus CM, Santos WL, Macdonald TL, Sofia RD, Kupferberg HJ: Reactivity of atropaldehyde, a felbamate metabolite in human liver tissue in vitro. Chem Biol Interact. 2002 Nov 10;142(1-2):119-34. Other members of this class of compounds, acrolein and (HNE), are known for their reactivity and toxicity. Aldehyde dehydrogenase (ALDH) and glutathione transferase (GST) are detoxifying enzymes and targets for reactive aldehydes. |
1(0,0,0,1) | Details |