| Name | tumor necrosis factor alpha |
|---|---|
| Synonyms | Cachectin; DIF; TNF; TNF alpha; TNF a; TNFA; TNFSF 2; TNFSF2… |
| Name | acrolein |
|---|---|
| CAS | 2-propenal |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15650393 | Valacchi G, Pagnin E, Phung A, Nardini M, Schock BC, Cross CE, van der Vliet A: Inhibition of NFkappaB activation and IL-8 expression in human bronchial epithelial cells by acrolein. Antioxid Redox Signal. 2005 Jan-Feb;7(1-2):25-31. Studies of nuclear factor-kappaB (NFkappaB) activation, an essential event in IL-8 production, showed decreased TNFalpha-induced NFkappaB activation by acrolein, illustrated by inhibition of nuclear translocation of NFkappaB and reduced IkappaBalpha degradation. |
112(1,2,2,2) | Details |
| 10198352 | Borchers MT, Carty MP, Leikauf GD: Regulation of human airway mucins by acrolein and inflammatory mediators. Am J Physiol. 1999 Apr;276(4 Pt 1):L549-55. MUC5AC mRNA levels increased after >/=0.01 nM acrolein, 10 microM or 1.0 nM tumor necrosis factor-alpha (TNF-alpha), or 10 nM phorbol 12- 13- (a protein kinase C activator). |
31(0,1,1,1) | Details |
| 18514610 | Parikh JG, Saraswathy S, Rao NA: Photoreceptor oxidative damage in sympathetic ophthalmia. . Am J Ophthalmol. 2008 Dec;146(6):866-75.e2. Epub 2008 Jun 2. Deparaffinized sections of the globes were processed to localize tumor necrosis factor-alpha (TNF-alpha), tumor necrosis factor receptor-1 (TNF-R1), acrolein, inducible synthase (iNOS), and nitrotyrosine by immunolocalization method. |
6(0,0,1,1) | Details |
| 18304597 | Liao BC, Hsieh CW, Liu YC, Tzeng TT, Sun YW, Wung BS: inhibits the tumor necrosis factor-alpha-induced expression of cell adhesion molecules in endothelial cells by suppressing NF-kappaB activation: effects upon IkappaB and Nrf2. Toxicol Appl Pharmacol. 2008 Jun 1;229(2):161-71. Epub 2008 Feb 5. |
4(0,0,0,4) | Details |
| 11956484 | Ribeiro RA, Freitas HC, Campos MC, Santos CC, Figueiredo FC, Brito GA, Cunha FQ: Tumor necrosis factor-alpha and interleukin-1beta mediate the production of involved in the pathogenesis of ifosfamide induced hemorrhagic cystitis in mice. J Urol. 2002 May;167(5):2229-34. Ifosfamide injected mice were pretreated with 10 to 40 mg./kg. of the synthesis inhibitor L-NG-nitroarginine methyl ester, 80 mg./kg. of mesna, a chemical antagonist of acrolein and the urotoxic metabolite of ifosfamide, 50 microl. antiserum against TNF-alpha and IL-1beta per mouse, 45 mg./kg. of the selective TNF-alpha synthesis inhibitor thalidomide or 200 mg./kg. of the TNF-alpha and IL-1beta synthesis inhibitor pentoxifylline. |
2(0,0,0,2) | Details |
| 11948286 | Malley SE, Vizzard MA: Changes in urinary bladder cytokine mRNA and protein after cyclophosphamide-induced cystitis. Physiol Genomics. 2002;9(1):5-13. An RNase protection assay was used to measure changes in rat bladder cytokine mRNA [interferon-gamma (IFN)-gamma, interleukin-1alpha/beta (IL-1alpha/beta), IL-2, IL-3, IL-4, IL-5, IL-6, IL-10, and tumor necrosis factor-alpha/beta (TNF-alpha/beta)] after acute (4 h), intermediate (48 h), or chronic (10 day) cystitis. |
1(0,0,0,1) | Details |
| 19080078 | Wang X, Li JQ, Chen L, Wang HX, Sun BB, Wang T, Xu D, Wen FQ: [Effects of phosphodiesterase-4 inhibitor on the mucin secretion in airway stimulated with acrolein: experiment with rats]. Zhonghua Yi Xue Za Zhi. 2008 Nov 18;88(42):2988-93. Bronchoalveolar lavage fluid (BALF) was acquired for cell count, and ELISA was used to detect the levels of tumor necrosis factor (TNF)-alpha and cytokine-induced neutrophil chemoattractant (CINC)-1 in the BALF. |
1(0,0,0,1) | Details |
| 17225077 | Korkmaz A, Topal T, Oter S: Pathophysiological aspects of cyclophosphamide and ifosfamide induced hemorrhagic cystitis; implication of reactive and species as well as PARP activation. Cell Biol Toxicol. 2007 Sep;23(5):303-12. Epub 2007 Jan 15. Acrolein is the main molecule responsible of this side-effect and mesna (2-mercaptoethane sulfonate) is the commonly used preventive agent. Thus, many cytokines such as tumor necrosis factor (TNF) and the interleukin (IL) family and transcription factors such as nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1) also play a role in its pathogenesis. |
1(0,0,0,1) | Details |
| 17868967 | Chao LK, Hua KF, Hsu HY, Cheng SS, Lin IF, Chen CJ, Chen ST, Chang ST: inhibits pro-inflammatory cytokines secretion from monocytes/macrophages through suppression of intracellular signaling. Food Chem Toxicol. 2008 Jan;46(1):220-31. Epub 2007 Aug 8. Although has been reported to have contact sensitizing properties at high concentration (mM), we found that low concentration of (muM) inhibited the secretion of interleukin-1beta and tumor necrosis factor alpha within lipopolysaccharide (LPS) or lipoteichoic acid (LTA) stimulated murine J774A.1 macrophages. |
1(0,0,0,1) | Details |
| 19464576 | Liu DS, Liu WJ, Chen L, Ou XM, Wang T, Feng YL, Zhang SF, Xu D, Chen YJ, Wen FQ: a peroxisome proliferator-activated receptor-gamma agonist, attenuates acrolein-induced airway mucus hypersecretion in rats. Toxicology. 2009 Jun 16;260(1-3):112-9. Epub 2009 Apr 5. The expressions of Muc5ac protein and mRNA, and infiltration of inflammatory cells and levels of inflammatory cytokines (interleukin (IL)-1beta, IL-8 and tumor necrosis factor (TNF)-alpha) in bronchoalveolar lavage fluid (BALF) were detected with real-time PCR, Western blot, cell counting and ELISA. |
1(0,0,0,1) | Details |
| 17491020 | Lambert C, Li J, Jonscher K, Yang TC, Reigan P, Quintana M, Harvey J, Freed BM: Acrolein inhibits cytokine gene expression by alkylating and residues in the NF-kappaB1 DNA binding domain. J Biol Chem. 2007 Jul 6;282(27):19666-75. Epub 2007 May 9. |
0(0,0,0,0) | Details |
| 11282106 | Xu X, Cubeddu LX, Malave A: Expression of inducible synthase in primary culture of rat bladder smooth muscle cells by plasma from cyclophosphamide-treated rats. Eur J Pharmacol. 2001 Mar 23;416(1-2):1-9. However, exposure to cyclophosphamide or to its metabolite acrolein (10 (-6)-10 (-4) M for 24 h) did not increase iNOS or NO-metabolite levels. |
0(0,0,0,0) | Details |