| Name | lecithin:cholesterol acyltransferase |
|---|---|
| Synonyms | LCAT; LAT; Lecithin cholesterol acyltransferase; Phosphatidylcholine sterol acyltransferase; Phosphatidylcholine sterol acyltransferase precursor; Phospholipid cholesterol acyltransferase; Lecithin cholesterol acyltransferases; Phosphatidylcholine sterol acyltransferases… |
| Name | acrolein |
|---|---|
| CAS | 2-propenal |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 7473602 | Chen C, Loo G: Inhibition of cholesterol acyltransferase activity in human blood plasma by cigarette smoke extract and reactive aldehydes. J Biochem Toxicol. 1995 Jun;10(3):121-8. Among five aldehydes tested, acrolein was the strongest inhibitor of LCAT, with complete enzyme inhibition occurring at 1 mM. |
94(1,1,2,9) | Details |
| 11223428 | Bielicki JK, Knoff LJ, Tribble DL, Forte TM: Relative sensitivities of plasma lecithin:cholesterol acyltransferase, platelet-activating factor acetylhydrolase, and paraoxonase to in vitro gas-phase cigarette smoke exposure. Atherosclerosis. 2001 Mar;155(1):71-8. Moreover, high doses (1.0-10 mM) of acrolein and reactive aldehydic species associated with cigarette smoke, completely inhibited plasma LCAT activity, whereas PAF-AH was resistant to such exposures. |
87(1,1,1,7) | Details |
| 7583533 | McCall MR, Tang JY, Bielicki JK, Forte TM: Inhibition of lecithin-cholesterol acyltransferase and modification of HDL apolipoproteins by aldehydes. Arterioscler Thromb Vasc Biol. 1995 Oct;15(10):1599-606. The short-chain (acrolein) and long-chain (HNE) alpha,beta-unsaturated aldehydes were the most effective LCAT inhibitors. |
38(0,1,1,8) | Details |