| Name | MUC5AC |
|---|---|
| Synonyms | MUC 5; Tracheobronchial mucin; MUC5; MUC5AC; Major airway glycoprotein; Mucin 5AC; TBM; Major airway glycoproteins… |
| Name | acrolein |
|---|---|
| CAS | 2-propenal |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 10198352 | Borchers MT, Carty MP, Leikauf GD: Regulation of human airway mucins by acrolein and inflammatory mediators. Am J Physiol. 1999 Apr;276(4 Pt 1):L549-55. MUC5AC mRNA levels increased after >/=0.01 nM acrolein, 10 microM or 1.0 nM tumor necrosis factor-alpha (TNF-alpha), or 10 nM phorbol 12- 13- (a protein kinase C activator). |
39(0,1,2,4) | Details |
| 12010847 | Leikauf GD, Borchers MT, Prows DR, Simpson LG: Mucin apoprotein expression in COPD. . Chest. 2002 May;121(5 Suppl):166S-182S. Recent studies with acrolein and cigarette smoke have suggested that MUC5AC is inducible (accompanied by epidermal growth factor [EGF] ligand formation and the activation of EGF receptor-dependent pathways), whereas MUC5B is constitutively expressed (increasing through gland enlargement). |
32(0,1,1,2) | Details |
| 18006877 | Deshmukh HS, Shaver C, Case LM, Dietsch M, Wesselkamper SC, Hardie WD, Korfhagen TR, Corradi M, Nadel JA, Borchers MT, Leikauf GD: Acrolein-activated matrix metalloproteinase 9 contributes to persistent mucin production. Am J Respir Cell Mol Biol. 2008 Apr;38(4):446-54. Epub 2007 Nov 15. Acrolein, a constituent of cigarette smoke and an endogenous mediator of oxidative stress, increases airway mucin 5, subtypes A and C (MUC5AC) production; however, the mechanism remains unclear. |
31(0,1,1,1) | Details |
| 19129291 | Wang T, Liu Y, Chen L, Wang X, Hu XR, Feng YL, Liu DS, Xu D, Duan YP, Lin J, Ou XM, Wen FQ: Effect of on acrolein-induced airway inflammation and mucus production in rats. Eur Respir J. 2009 May;33(5):1122-32. Epub 2009 Jan 7. Moreover, pretreatment reduced acrolein-induced Muc5ac mucin synthesis at both mRNA and protein levels, and attenuated airway inflammation, as well as epithelial hyperplasia and metaplasia. |
31(0,1,1,1) | Details |
| 9575876 | Borchers MT, Wert SE, Leikauf GD: Acrolein-induced MUC5ac expression in rat airways. Am J Physiol. 1998 Apr;274(4 Pt 1):L573-81. |
24(0,0,3,9) | Details |
| 20060463 | Haswell LE, Hewitt K, Thorne D, Richter A, Gaca MD: Cigarette smoke total particulate matter increases mucous secreting cell numbers in vitro: a potential model of goblet cell hyperplasia. Toxicol In Vitro. 2010 Apr;24(3):981-7. Epub 2010 Jan 7. Acrolein treatment also increased the percentage of MUC5AC positive cells. |
9(0,0,1,4) | Details |
| 19464576 | Liu DS, Liu WJ, Chen L, Ou XM, Wang T, Feng YL, Zhang SF, Xu D, Chen YJ, Wen FQ: a peroxisome proliferator-activated receptor-gamma agonist, attenuates acrolein-induced airway mucus hypersecretion in rats. Toxicology. 2009 Jun 16;260(1-3):112-9. Epub 2009 Apr 5. RESULTS: Acrolein exposure significantly induced goblet cell hyperplasia in bronchial epithelium and Muc5ac mRNA and protein expressions in rat lungs, as well as the associated airway inflammation evidenced by the increased numbers of inflammatory cells and levels of inflammatory cytokines in BALF, which were attenuated with treatment in a dose-dependent manner (P <0.05). |
7(0,0,1,2) | Details |
| 19631294 | Liu DS, Wang T, Han SX, Dong JJ, Liao ZL, He GM, Chen L, Chen YJ, Xu D, Hou Y, Li YP, Wen FQ: p38 MAPK and MMP-9 cooperatively regulate mucus overproduction in mice exposed to acrolein fog. Int Immunopharmacol. 2009 Sep;9(10):1228-35. Epub 2009 Jul 22. Moreover, SB203580 treatment decreased the acrolein-induced increase of Muc5ac and MMP-9 expression and MMP-9 activity in airway epithelium. |
7(0,0,1,2) | Details |
| 19080078 | Wang X, Li JQ, Chen L, Wang HX, Sun BB, Wang T, Xu D, Wen FQ: [Effects of phosphodiesterase-4 inhibitor on the mucin secretion in airway stimulated with acrolein: experiment with rats]. Zhonghua Yi Xue Za Zhi. 2008 Nov 18;88(42):2988-93. Muc5ac protein was measured by immunohistochemical staining and Western-blotting, and Muc5ac mRNA was detected by RT-PCR. |
4(0,0,0,4) | Details |
| 18602273 | Rummenie VT, Matsumoto Y, Dogru M, Wang Y, Hu Y, Ward SK, Igarashi A, Wakamatsu T, Ibrahim O, Goto E, Luyten G, Inoue H, Saito I, Shimazaki J, Tsubota K: Tear cytokine and ocular surface alterations following brief passive cigarette smoke exposure. Cytokine. 2008 Aug;43(2):200-8. Epub 2008 Jul 3. IC and RT-PCR revealed a significant reduction in goblet cell density, a shift toward higher squamous metaplasia grades and a significant downregulation of MUC5AC mRNA expression at 24 h. Tear samples were obtained before, 5 min and 24 h after smoke exposure to detect tear hexanoyl- (HEL), acrolein and inflammatory cytokine concentrations. |
1(0,0,0,1) | Details |
| 18972840 | Pokharel YR, Yoon SY, Kim SK, Li JD, Kang KW: Inhibition of acrolein-stimulated MUC5AC production by fucoidan in human bronchial epithelial cells. Pharmazie. 2008 Oct;63(10):757-9. |
246(3,3,3,6) | Details |
| 15531749 | Deshmukh HS, Case LM, Wesselkamper SC, Borchers MT, Martin LD, Shertzer HG, Nadel JA, Leikauf GD: Metalloproteinases mediate mucin 5AC expression by epidermal growth factor receptor activation. Am J Respir Crit Care Med. 2005 Feb 15;171(4):305-14. Epub 2004 Nov 5. Acrolein, a component of cigarette smoke, increases mucin 5AC (MUC5AC), a prevalent airway mucin in NCI-H292 cells by transcriptional activation, but the signal transduction pathways involved in acrolein-induced MUC5AC expression are unknown. |
137(0,4,6,7) | Details |
| 19661247 | Deshmukh HS, McLachlan A, Atkinson JJ, Hardie WD, Korfhagen TR, Dietsch M, Liu Y, Di PY, Wesselkamper SC, Borchers MT, Leikauf GD: Matrix metalloproteinase-14 mediates a phenotypic shift in the airways to increase mucin production. Am J Respir Crit Care Med. 2009 Nov 1;180(9):834-45. Epub 2009 Aug 6. Decreasing the MMP14 protein and activity in vitro by small interfering (si) RNA to MMP14 diminished the acrolein-induced MUC5AC transcripts. |
62(0,2,2,2) | Details |
| 10484456 | Borchers MT, Wesselkamper S, Wert SE, Shapiro SD, Leikauf GD: Monocyte inflammation augments acrolein-induced Muc5ac expression in mouse lung. Am J Physiol. 1999 Sep;277(3 Pt 1):L489-97. The magnitude of macrophage accumulation coincided with increased Muc5ac mRNA levels, indicating that excessive macrophage accumulation augments acrolein-induced Muc5ac synthesis and secretion after repeated exposure. |
51(0,1,4,6) | Details |
| 19576043 | Liu WJ, Li WC, Xu ZB, Feng YL: [Effect of peroxisome proliferators activated receptor gamma and its ligand on airway mucus hypersecretion in rats]. Zhonghua Jie He He Hu Xi Za Zhi. 2009 Apr;32(4):282-6. PPAR-gamma and its ligand inhibited acrolein-induced airway mucus hypersecretion, possibly through downregulation of MUC5AC. |
50(0,1,4,5) | Details |
| 18630690 | Guan AY, Xu ZB, Wen FQ, Wang BD, Feng YL: [Effect of gefinitib on airway mucus hypersecretion induced by acrolein in rats]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2008 Mar;39(2):231-4. Gefitinib intervention inhibited the expression of MUC5AC and the increase of goblet cells induced by acrolein. |
44(0,1,3,4) | Details |