| Name | Lipoxygenase (protein family or complex) |
|---|---|
| Synonyms | arachidonate lipoxygenase; arachidonate lipoxygenases; lipoxygenase; lipoxygenases |
| Name | acrolein |
|---|---|
| CAS | 2-propenal |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 8002544 | Janssens SP, Musto SW, Hutchison WG, Spence C, Witten M, Jung W, Hales CA: Cyclooxygenase and lipoxygenase inhibition by BW-755C reduces acrolein smoke-induced acute lung injury. J Appl Physiol. 1994 Aug;77(2):888-95. |
112(1,2,2,2) | Details |
| 8149893 | Kanekal S, Kehrer JP: Metabolism of cyclophosphamide by lipoxygenases. . Drug Metab Dispos. 1994 Jan-Feb;22(1):74-8. Incubations of CP (0-5 mM) with soybean lipoxygenase (0-1 x 10 (4) units) and (0-5 mM) resulted in the generation of acrolein, an easily detected breakdown product of the initial unstable hydroxylated CP metabolite. |
72(0,2,3,7) | Details |
| 7713845 | Hales CA, Musto S, Hutchison WG, Mahoney E: BW-755C diminishes smoke-induced pulmonary edema. . J Appl Physiol. 1995 Jan;78(1):64-9. We, therefore, hypothesized that acrolein, a component of smoke from burning cotton, might have a major role in producing pulmonary edema in sheep after cotton smoke inhalation and that BW-755C, a combined cyclo- and lipoxygenase inhibitor, would prevent the edema, whereas indomethacin, a cyclooxygenase inhibitor, would not. |
31(0,1,1,1) | Details |
| 2221083 | Doupnik CA, Leikauf GD: Acrolein stimulates eicosanoid release from bovine airway epithelial cells. Am J Physiol. 1990 Oct;259(4 Pt 1):L222-9. After exposure to acrolein, significant "peaks" in 3H activity coeluted with the lipoxygenase products (HETE) and 15-HETE, as well as with PGF2 alpha, and 6-keto-PGF1 alpha. |
31(0,1,1,1) | Details |
| 11080206 | Rao AM, Hatcher JF, Dempsey RJ: Lipid alterations in transient forebrain ischemia: possible new mechanisms of CDP- neuroprotection. J Neurochem. 2000 Dec;75(6):2528-35. Released ArAc is metabolized by cyclooxygenases/lipoxygenases to form eicosanoids and reactive oxygen species (ROS). ROS contribute to neurotoxicity through generation of lipid peroxides and the cytotoxic byproducts and acrolein. |
1(0,0,0,1) | Details |
| 11525870 | Blair IA: Lipid hydroperoxide-mediated DNA damage. Exp Gerontol. 2001 Sep;36(9):1473-81. They are also formed as specific products of lipoxygenases and cyclooxygenases. Malondialdehyde (beta-hydroxy-acrolein), another genotoxic bifunctional electrophile, is formed during homolytic decomposition of lipid hydroperoxides that contain more than two double bonds. |
1(0,0,0,1) | Details |
| 16500992 | Davoine C, Falletti O, Douki T, Iacazio G, Ennar N, Montillet JL, Triantaphylides C: Adducts of oxylipin electrophiles to reflect a 13 specificity of the downstream lipoxygenase pathway in the tobacco hypersensitive response. Plant Physiol. 2006 Apr;140(4):1484-93. Epub 2006 Feb 24. In this model, the adducts arise mainly from the downstream 13 lipoxygenase (LOX) metabolism, although the induced 9 LOX pathway leads massively to the accumulation of upstream metabolites. |
1(0,0,0,1) | Details |
| 8367612 | Ben-Jebria A, Marthan R, Rossetti M, Savineau JP, Ultman JS: Effect of in vitro exposure to acrolein on carbachol responses in rat trachealis muscle. Respir Physiol. 1993 Jul;93(1):111-23. At lower concentrations, inhibition by these two chemicals was partially additive, suggesting that both the lipoxygenase and cyclo-oxygenase pathways play a role in the hyperreactive response. |
1(0,0,0,1) | Details |