| Name | polyamine oxidase |
|---|---|
| Synonyms | PAO; PAOX; Peroxisomal N1 acetyl spermine/spermidine oxidase; Polyamine oxidase; RP11 122K13.11; UNQ1923/PRO4398; polyamine oxidase (exo N4 amino); PAO… |
| Name | acrolein |
|---|---|
| CAS | 2-propenal |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 8784495 | Johnson WC, Cluff CW, Goff WL, Wyatt CR: Reactive and intermediates and products from polyamine degradation are Babesiacidal in vitro. Ann N Y Acad Sci. 1996 Jul 23;791:136-47. degradation by polyamine oxidase and direct addition of acrolein was toxic in a dose-dependent manner. |
81(1,1,1,1) | Details |
| 19661476 | Saiki R, Nishimura K, Ishii I, Omura T, Okuyama S, Kashiwagi K, Igarashi K: Intense correlation between brain infarction and protein-conjugated acrolein. Stroke. 2009 Oct;40(10):3356-61. Epub 2009 Aug 6. BACKGROUND AND PURPOSE: We recently found that increases in plasma levels of protein-conjugated acrolein and polyamine oxidases, enzymes that produce acrolein, are good markers for stroke. |
62(0,2,2,2) | Details |
| 16269634 | Tomitori H, Usui T, Saeki N, Ueda S, Kase H, Nishimura K, Kashiwagi K, Igarashi K: Polyamine oxidase and acrolein as novel biochemical markers for diagnosis of cerebral stroke. Stroke. 2005 Dec;36(12):2609-13. Epub 2005 Nov 3. |
19(0,0,3,4) | Details |
| 16819267 | Igarashi K: [Physiological functions of polyamines and regulation of polyamine content in cells]. Yakugaku Zasshi. 2006 Jul;126(7):455-71. Finally, the correlation between acrolein produced from polyamines by polyamine oxidase and chronic renal failure and brain stroke is summarized. |
12(0,0,2,2) | Details |
| 19643201 | Igarashi K, Kashiwagi K: Modulation of cellular function by polyamines. Int J Biochem Cell Biol. 2010 Jan;42(1):39-51. Epub 2009 Jul 28. Finally, a correlation between acrolein, produced from polyamines by polyamine oxidases, and chronic renal failure or brain stroke is summarized. |
12(0,0,2,2) | Details |
| 12732208 | Sakata K, Kashiwagi K, Sharmin S, Ueda S, Irie Y, Murotani N, Igarashi K: Increase in amine oxidase, and acrolein in plasma of renal failure patients. Biochem Biophys Res Commun. 2003 May 23;305(1):143-9. It was found that acrolein is mainly produced by polyamine oxidase in plasma. |
7(0,0,1,2) | Details |
| 18757054 | Yoshida M, Tomitori H, Machi Y, Katagiri D, Ueda S, Horiguchi K, Kobayashi E, Saeki N, Nishimura K, Ishii I, Kashiwagi K, Igarashi K: Acrolein, IL-6 and CRP as markers of silent brain infarction. . Atherosclerosis. 2009 Apr;203(2):557-62. Epub 2008 Jul 26. We found previously that increased levels of polyamine oxidase (PAO) [acetylpolyamine oxidase (AcPAO) plus spermine oxidase (SMO)], and acrolein (CH (2) CHCHO) are good markers of stroke. |
6(0,0,1,1) | Details |
| 17362887 | Wood PL, Khan MA, Moskal JR: The concept of load" in neurodegenerative mechanisms: cytotoxicity of the polyamine degradation products peroxide, acrolein, 3-acetamidopropanal and in a retinal ganglion cell line. Brain Res. 2007 May 11;1145:150-6. Epub 2007 Mar 23. The major aldehydes produced by polyamine oxidase and amine oxidases include the 2-alkenal acrolein, the acetoamidoaldehyde 3-acetamidopropanal (3-AAP) and the aminoaldehydes (3-AP) and (4-AB). |
6(0,0,1,1) | Details |
| 7577467 | Fernandez C, Sharrard RM, Talbot M, Reed BD, Monks N: Evaluation of the significance of polyamines and their oxidases in the aetiology of human cervical carcinoma. Br J Cancer. 1995 Nov;72(5):1194-9. These amines are oxidised by polyamine oxidase (PAO) and diamine oxidase (DAO) to generate radicals and peroxide, reactive aldehydes and acrolein, which are likely to exert local mutagenic, cytotoxic and immunosuppressive effects in vivo. |
6(0,0,1,1) | Details |
| 6381596 | Ferrante A, Rzepczyk CM, Saul AJ: Polyamine oxidase-mediated trypanosome killing: the role of peroxide and aldehydes. J Immunol. 1984 Oct;133(4):2157-62. These included peroxide (H2O2), the acrolein, and possibly aminoaldehydes. |
2(0,0,0,2) | Details |
| 3744554 | Ferrante A, Ljungstrom I, Rzepczyk CM, Morgan DM: Differences in sensitivity of Schistosoma mansoni schistosomula, Dirofilaria immitis microfilariae, and Nematospiroides dubius third-stage larvae to damage by the polyamine oxidase-polyamine system. Infect Immun. 1986 Sep;53(3):606-10. |
2(0,0,0,2) | Details |
| 2264722 | Levitz SM, DiBenedetto DJ, Diamond RD: Inhibition and killing of fungi by the polyamine oxidase-polyamine system. Antonie Van Leeuwenhoek. 1990 Aug;58(2):107-14. Two putative end products of the system, peroxide and acrolein, both killed C. neoformans at concentrations attainable with the whole system. |
2(0,0,0,2) | Details |
| 3980049 | Ferrante A: Inhibition of human neutrophil locomotion by the polyamine oxidase-polyamine system. Immunology. 1985 Apr;54(4):785-90. Acrolein, a breakdown product of other products (aminoaldehydes), was found to inhibit the neutrophil functions. |
2(0,0,0,2) | Details |
| 19639169 | Agostinelli E, Condello M, Molinari A, Tempera G, Viceconte N, Arancia G: Cytotoxicity of oxidation products to multidrug resistant melanoma M14 ADR2 cells: sensitization by the MDL 72527 lysosomotropic compound. Int J Oncol. 2009 Sep;35(3):485-98. The metabolites formed by BSAO and are more toxic than exogenous H2O2 and acrolein, even though their concentration is lower during the initial phase of incubation due to their more gradual release than the exogenous products. Both wild-type and MDR cells, after pre-treatment with MDL 72527, an inactivator of polyamine oxidase and a lysosomotropic compound, show to be sensitized to subsequent exposure to BSAO/ |
1(0,0,0,1) | Details |
| 6585180 | Frolik CA, Roller PP, Cone JL, Dart LL, Smith DM, Sporn MB: Inhibition of transforming growth factor-induced cell growth in soft agar by oxidized polyamines. Arch Biochem Biophys. 1984 Apr;230(1):93-102. Evidence suggests that the polyamines must first be oxidized by serum polyamine oxidase before inhibition will occur. Acrolein, a product of polyamine oxidation, will also inhibit cell growth in soft agar with an ED50 of 6.8 microM. |
1(0,0,0,1) | Details |
| 3678446 | Traore-Leroux T, Fumoux F, Chaize J, Roelants GE: Trypanosoma brucei: polyamine oxidase mediated trypanolytic activity in the serum of naturally resistant cattle. Exp Parasitol. 1987 Dec;64(3):401-9. Oxidation of by polyamine oxidase leads to the production of unstable aldehydes, acrolein, O2-, HO, and H2O2. |
84(1,1,1,4) | Details |
| 16554974 | Igarashi K, Ueda S, Yoshida K, Kashiwagi K: Polyamines in renal failure. . Amino Acids. 2006 Nov;31(4):477-83. Epub 2006 Mar 24. As acrolein was a major toxic compound produced from by polyamine oxidase, the levels of free and protein-conjugated acrolein in plasma were also measured. |
83(1,1,1,3) | Details |
| 17026969 | Wood PL, Khan MA, Moskal JR, Todd KG, Tanay VA, Baker G: load in ischemia-reperfusion brain injury: neuroprotection by neutralization of reactive aldehydes with phenelzine. Brain Res. 2006 Nov 29;1122(1):184-90. Epub 2006 Oct 5. Both aminoaldehydes and acrolein are generated from the metabolism of polyamines to by polyamine oxidase. |
81(1,1,1,1) | Details |