Protein Information

Name H2AX
Synonyms H2A.X; H2A/X; H2AFX; H2AX; H2AX histone; Histone H2A.x; gamma H2AX; H2AX histones…

Compound Information

Name acrolein
CAS 2-propenal

Reference List

PubMed Abstract RScore(About this table)
18381427 Wei G, DeFeo K, Hayes CS, Woster PM, Mandik-Nayak L, Gilmour SK: Elevated ornithine decarboxylase levels activate ataxia telangiectasia mutated-DNA damage signaling in normal keratinocytes. Cancer Res. 2008 Apr 1;68(7):2214-22.

Ker/ODC also displays increased generation of H (2) O (2), acrolein-lysine conjugates, and protein oxidation products as well as polyamine-dependent DNA damage, as measured by the comet assay and the expression of the phosphorylated form of the histone variant gamma H2AX.
81(1,1,1,1) Details
18096571 Malmlof M, Paajarvi G, Hogberg J, Stenius U: Mdm2 as a sensitive and mechanistically informative marker for genotoxicity induced by benzo [a] pyrene and dibenzo [a,l] pyrene. Toxicol Sci. 2008 Apr;102(2):232-40. Epub 2007 Dec 20.


Acrolein potentiated the effect of BP on p53 stabilization and chromatin binding.
0(0,0,0,0) Details